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    PUR4 purine biosynthesis 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843766, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PUR4
    Official Full Name
    purine biosynthesis 4
    Primary source
    TAIR:AT1G74260
    Locus tag
    AT1G74260
    See related
    Araport:AT1G74260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F1O17.7; F1O17_7; purine biosynthesis 4
    Summary
    Encodes formylglycinamidine ribonucleotide synthase an enzyme involved in de novo purine biosynthesis. PUR4 is localizes to the chloroplast and mitochondria. Loss of PUR4 function affects male but not female gametophyte development.
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    Genomic context

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    See PUR4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (27922725..27927962, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Mitochondrial substrate carrier family protein Neighboring gene DNAJ heat shock N-terminal domain-containing protein Neighboring gene Ribosomal protein L35Ae family protein Neighboring gene alpha/beta-Hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. pur4 mutations are lethal to the male, but not the female, gametophyte and affect sporophyte development in Arabidopsis. Berthomé R, et al. Plant Physiol, 2008 Jun. PMID 18441219, Free PMC Article
    2. Assembly of an interactive correlation network for the Arabidopsis genome using a novel heuristic clustering algorithm. Mutwil M, et al. Plant Physiol, 2010 Jan. PMID 19889879, Free PMC Article
    3. Analysis of the soluble ATP-binding proteome of plant mitochondria identifies new proteins and nucleotide triphosphate interactions within the matrix. Ito J, et al. J Proteome Res, 2006 Dec. PMID 17137349
    4. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
    5. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_106086.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables phosphoribosylformylglycinamidine synthase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within microgametogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    purine biosynthesis 4
    NP_177566.3
    • purine biosynthesis 4 (PUR4); FUNCTIONS IN: phosphoribosylformylglycinamidine synthase activity, catalytic activity, ATP binding; INVOLVED IN: microgametogenesis, pollen development; LOCATED IN: mitochondrion, chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: PurM, N-terminal-like (InterPro:IPR016188), Phosphoribosylformylglycinamidine synthase, eukaryote/proteobacteria (InterPro:IPR010073), AIR synthase related protein (InterPro:IPR000728), AIR synthase related protein, C-terminal (InterPro:IPR010918), Glutamine amidotransferase type 1 (InterPro:IPR017926); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27922725..27927962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106086.5 → NP_177566.3  purine biosynthesis 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177566.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9Y5J1, F4HTW2, Q9M8D3
      UniProtKB/TrEMBL
      A0A7G2E4I6
      Conserved Domains (4) summary
      cd02203
      Location:303 → 686
      PurL_repeat1; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
      cd02204
      Location:787 → 1061
      PurL_repeat2; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
      PLN03206
      Location:102 → 1405
      PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
      pfam13507
      Location:1139 → 1404
      GATase_5; CobB/CobQ-like glutamine amidotransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M8D3.3

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