CDC48 cell division cycle 48 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CDC48
Official Full Name: cell division cycle 48
Primary source: TAIR:AT3G09840
Locus tag: AT3G09840
See related: Araport:AT3G09840
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCDC48; CDC48A; cell division cycle 48
Summary: Encodes a cell division cycle protein, a member of AAA-type ATPases gene family. Expressed throughout the plant in regions of cell division. Within the cell, sub-cellular localization varies depending on the stage of the cell cycle.Mutants in which the expression of CDC48A is altered show defects in cytokinesis, cell expansion and cell differentiation.
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Genomic context

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See CDC48 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 8

Sequence:: Chromosome: 3; NC_003074.8 (3019249..3023052)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDC48A, an interactor of WOX2, is required for embryonic patterning in Arabidopsis thaliana.
Title: CDC48A, an interactor of WOX2, is required for embryonic patterning in Arabidopsis thaliana.
The CDC48 complex mediates ubiquitin-dependent degradation of intra-chloroplast proteins in plants.
Title: The CDC48 complex mediates ubiquitin-dependent degradation of intra-chloroplast proteins in plants.
Common mode of remodeling of human and Arabidopsis thaliana AAA ATPases p97/CDC48 by their disassembling cofactors ASPL/PUX1 has been described.
Title: Common Mode of Remodeling AAA ATPases p97/CDC48 by Their Disassembling Cofactors ASPL/PUX1.
This work identified SP2 (AT3G44160) and CDC48 as functional partners of the SP1 E3 ligase and, in so doing, defined a multicomponent system for chloroplast protein degradation involving integral outer envelope membrane and cytosolic factors.
Title: Ubiquitin-dependent chloroplast-associated protein degradation in plants.
As an AAA ATPase, AtCDC48A likely serves to process the polyubiquitinated NLR substrate for final protein degradation by the 26S proteasome. [AtCDC48A]
Title: AtCDC48A is involved in the turnover of an NLR immune receptor.
results indicate that the CDC48A(NPL4) complex actively removes sumoylated CenH3 from centromeres and disrupts centromeric heterochromatin to release bulk rRNA genes into the nucleolus for ribosome production.
Title: The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes.
Arabidopsis (Arabidopsis thaliana) CDC48 is induced upon infection, interacts with MP in endoplasmic reticulum inclusions dependent on the MP N terminus, and promotes degradation of the protein.
Title: Control of Tobacco mosaic virus movement protein fate by CELL-DIVISION-CYCLE protein48.
critical for cytokinesis, cell expansion, and differentiation in plants
Title: In planta analysis of the cell cycle-dependent localization of AtCDC48A and its critical roles in cell division, expansion, and differentiation.
Employing fluorescence correlation spectroscopy, it was shown that CDC48A hexamers are part of larger complexes.
Title: In vivo hexamerization and characterization of the Arabidopsis AAA ATPase CDC48A complex using forster resonance energy transfer-fluorescence lifetime imaging microscopy and fluorescence correlation spectroscopy.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_111819.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen germination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen tube growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in cytosolic ribosome	HDA more info	PubMed
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in phragmoplast	IDA Inferred from Direct Assay more info	PubMed
located_in plant-type cell wall	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in plasmodesma	HDA more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cell division cycle 48

NP_187595.1

cell division cycle 48 (CDC48); FUNCTIONS IN: ATPase activity, identical protein binding; INVOLVED IN: response to cadmium ion, pollen germination, pollen tube growth, cell division, phosphorylation; LOCATED IN: in 9 components; EXPRESSED IN: 33 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA-type, conserved site (InterPro:IPR003960), Aspartate decarboxylase-like fold (InterPro:IPR009010), Cell division protein 48, CDC48, domain 2 (InterPro:IPR004201), ATPase, AAA-type, VAT, N-terminal (InterPro:IPR003338), ATPase, AAA-type, CDC48 (InterPro:IPR005938); BEST Arabidopsis thaliana protein match is: ATPase, AAA-type, CDC48 protein (TAIR:AT5G03340.1); Has 66378 Blast hits to 39099 proteins in 3298 species: Archae - 1713; Bacteria - 29252; Metazoa - 8676; Fungi - 6302; Plants - 5800; Viruses - 77; Other Eukaryotes - 14558 (source: NCBI BLink).