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    LTA2 2-oxoacid dehydrogenases acyltransferase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822181, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LTA2
    Official Full Name
    2-oxoacid dehydrogenases acyltransferase family protein
    Primary source
    TAIR:AT3G25860
    Locus tag
    AT3G25860
    See related
    Araport:AT3G25860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DIHYDROLIPOAMIDE S-ACETYLTRANSFERASE; PLASTID E2 SUBUNIT OF PYRUVATE DECARBOXYLASE; PLE2
    Summary
    Nuclear encoded dihydrolipoamide S-acetyltransferase (LTA2) that encodes teh Pyruvate Decarboxylase E2 subunit. Mutant has embryo defect.
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    Genomic context

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    See LTA2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (9460433..9463013)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene Copper transport protein family Neighboring gene uncharacterized protein Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel regulatory mechanism based upon a dynamic core structure for the mitochondrial pyruvate dehydrogenase complex? Broz AK, et al. Mitochondrion, 2014 Nov. PMID 24846799
    2. Mapping the lipoylation site of Arabidopsis thaliana plastidial dihydrolipoamide S-acetyltransferase using mass spectrometry and site-directed mutagenesis. Casteel J, et al. Plant Physiol Biochem, 2011 Nov. PMID 21798751
    3. Cloning and characterization of the dihydrolipoamide S-acetyltransferase subunit of the plastid pyruvate dehydrogenase complex (E2) from Arabidopsis. Mooney BP, et al. Plant Physiol, 1999 Jun. PMID 10364395, Free PMC Article
    4. The 14-3-3 isoforms chi and epsilon differentially bind client proteins from developing Arabidopsis seed. Swatek KN, et al. J Proteome Res, 2011 Sep 2. PMID 21766784
    5. High heterogeneity within the ribosomal proteins of the Arabidopsis thaliana 80S ribosome. Giavalisco P, et al. Plant Mol Biol, 2005 Mar. PMID 15821981

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The A. thaliana plastidial E2 subunit includes a single lipoyl-prosthetic group covalently attached to Lys96.
      Title: Mapping the lipoylation site of Arabidopsis thaliana plastidial dihydrolipoamide S-acetyltransferase using mass spectrometry and site-directed mutagenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_113489.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dihydrolipoyllysine-residue acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast thylakoid HDA PubMed 
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in cytosolic ribosome HDA PubMed 
    part_of pyruvate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2-oxoacid dehydrogenases acyltransferase family protein
    NP_189215.1
    • LTA2; FUNCTIONS IN: dihydrolipoyllysine-residue acetyltransferase activity; INVOLVED IN: metabolic process, acetyl-CoA biosynthetic process from pyruvate; LOCATED IN: cytosolic ribosome, chloroplast stroma, chloroplast, membrane, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: 2-oxo acid dehydrogenase, lipoyl-binding site (InterPro:IPR003016), E3 binding (InterPro:IPR004167), 2-oxoacid dehydrogenase acyltransferase, catalytic domain (InterPro:IPR001078), Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: 2-oxoacid dehydrogenases acyltransferase family protein (TAIR:AT1G34430.1); Has 23844 Blast hits to 20819 proteins in 2344 species: Archae - 101; Bacteria - 13163; Metazoa - 1146; Fungi - 799; Plants - 467; Viruses - 32; Other Eukaryotes - 8136 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      9460433..9463013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113489.3 → NP_189215.1  2-oxoacid dehydrogenases acyltransferase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189215.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LUA6, Q9SQI8
      UniProtKB/TrEMBL
      A0A178V5Z1, A0A5S9XFR8
      Conserved Domains (1) summary
      PRK11856
      Location:55 → 480
      PRK11856; branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SQI8.1

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