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    EIN3 Ethylene insensitive 3 family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821625, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EIN3
    Official Full Name
    Ethylene insensitive 3 family protein
    Primary source
    TAIR:AT3G20770
    Locus tag
    AT3G20770
    See related
    Araport:AT3G20770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtEIN3; ETHYLENE-INSENSITIVE3
    Summary
    Encodes EIN3 (ethylene-insensitive3), a nuclear transcription factor that initiates downstream transcriptional cascades for ethylene responses.
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    Genomic context

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    See EIN3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (7260429..7263384, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene GATA transcription factor 29 Neighboring gene Nse4, component of Smc5/6 DNA repair complex Neighboring gene topoisomerase 6 subunit B Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhanced oxidative stress in the ethylene-insensitive (ein3-1) mutant of Arabidopsis thaliana exposed to salt stress. Asensi-Fabado MA, et al. J Plant Physiol, 2012 Mar 1. PMID 22209220
    2. Ethylene signaling cross-talk with other hormones in Arabidopsis thaliana exposed to contrasting phosphate availability: Differential effects in roots, leaves and fruits. Munné-Bosch S, et al. J Plant Physiol, 2018 Jul. PMID 29758376
    3. Allosteric deactivation of PIFs and EIN3 by microproteins in light control of plant development. Wu Q, et al. Proc Natl Acad Sci U S A, 2020 Aug 4. PMID 32694206, Free PMC Article
    4. The Arabidopsis AMOT1/EIN3 gene plays an important role in the amelioration of ammonium toxicity. Li G, et al. J Exp Bot, 2019 Feb 20. PMID 30689938, Free PMC Article
    5. Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis. Chang KN, et al. Elife, 2013 Jun 11. PMID 23795294, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ETHYLENE INSENSITIVE3/EIN3-LIKE1 modulate FLOWERING LOCUS C expression via histone demethylase interaction.
      Title: ETHYLENE INSENSITIVE3/EIN3-LIKE1 modulate FLOWERING LOCUS C expression via histone demethylase interaction.
    2. EIN3 and RSL4 interfere with an MYB-bHLH-WD40 complex to mediate ethylene-induced ectopic root hair formation in Arabidopsis.
      Title: EIN3 and RSL4 interfere with an MYB-bHLH-WD40 complex to mediate ethylene-induced ectopic root hair formation in Arabidopsis.
    3. MYB30 and ETHYLENE INSENEITIVE3 antagonistically regulate root hair growth and phosphorus uptake under phosphate deficiency in Arabidopsis.
      Title: MYB30 and ETHYLENE INSENEITIVE3 antagonistically regulate root hair growth and phosphorus uptake under phosphate deficiency in Arabidopsis.
    4. EIN3-Mediated Ethylene Signaling Attenuates Auxin Response during Hypocotyl Thermomorphogenesis.
      Title: EIN3-Mediated Ethylene Signaling Attenuates Auxin Response during Hypocotyl Thermomorphogenesis.
    5. MYB30 and ETHYLENE INSENSITIVE3 antagonistically modulate root hair growth in Arabidopsis.
      Title: MYB30 and ETHYLENE INSENSITIVE3 antagonistically modulate root hair growth in Arabidopsis.
    6. EIN2-directed histone acetylation requires EIN3-mediated positive feedback regulation in response to ethylene.
      Title: EIN2-directed histone acetylation requires EIN3-mediated positive feedback regulation in response to ethylene.
    7. The RING E3 ligase SDIR1 destabilizes EBF1/EBF2 and modulates the ethylene response to ambient temperature fluctuations in Arabidopsis.
      Title: The RING E3 ligase SDIR1 destabilizes EBF1/EBF2 and modulates the ethylene response to ambient temperature fluctuations in Arabidopsis.
    8. TREE1-EIN3-mediated transcriptional repression inhibits shoot growth in response to ethylene.
      Title: TREE1-EIN3-mediated transcriptional repression inhibits shoot growth in response to ethylene.
    9. Salicylic Acid Suppresses Apical Hook Formation via NPR1-Mediated Repression of EIN3 and EIL1 in Arabidopsis.
      Title: Salicylic Acid Suppresses Apical Hook Formation via NPR1-Mediated Repression of EIN3 and EIL1 in Arabidopsis.
    10. Allosteric deactivation of PIFs and EIN3 by microproteins in light control of plant development.
      Title: Allosteric deactivation of PIFs and EIN3 by microproteins in light control of plant development.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_112968.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ethylene-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ethylene-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ethylene-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of L-ascorbic acid biosynthetic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ethylene IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sugar mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ethylene insensitive 3 family protein
    NP_188713.1
    • ETHYLENE-INSENSITIVE3 (EIN3); CONTAINS InterPro DOMAIN/s: Ethylene insensitive 3 (InterPro:IPR006957); BEST Arabidopsis thaliana protein match is: ETHYLENE-INSENSITIVE3-like 1 (TAIR:AT2G27050.1); Has 12681 Blast hits to 4386 proteins in 108 species: Archae - 12; Bacteria - 9; Metazoa - 78; Fungi - 631; Plants - 331; Viruses - 0; Other Eukaryotes - 11620 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7260429..7263384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112968.4 → NP_188713.1  Ethylene insensitive 3 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188713.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O24606, Q8VYW4
      UniProtKB/TrEMBL
      A0A178VGP6, A0A5S9XEH1
      Conserved Domains (1) summary
      pfam04873
      Location:49 → 296
      EIN3; Ethylene insensitive 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O24606.1

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