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    RHD3 Root hair defective 3 GTP-binding protein (RHD3) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820600, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RHD3
    Official Full Name
    Root hair defective 3 GTP-binding protein (RHD3)
    Primary source
    TAIR:AT3G13870
    Locus tag
    AT3G13870
    See related
    Araport:AT3G13870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    GOLGI MUTANT 8; GOM8; ROOT HAIR DEFECTIVE 3
    Summary
    required for regulated cell expansion and normal root hair development. Encodes an evolutionarily conserved protein with putative GTP-binding motifs that is implicated in the control of vesicle trafficking between the endoplasmic reticulum and the Golgi compartments.
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    Genomic context

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    See RHD3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    23
    Sequence:
    Chromosome: 3; NC_003074.8 (4565370..4571355, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene heat shock protein 60-3A Neighboring gene ncRNA Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Ribosomal protein L34

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis RHD3 gene is required for cell wall biosynthesis and actin organization. Hu Y, et al. Planta, 2003 Oct. PMID 12844267
    2. A GFP-based assay reveals a role for RHD3 in transport between the endoplasmic reticulum and Golgi apparatus. Zheng H, et al. Plant J, 2004 Feb. PMID 14731265
    3. Loss-of-function mutations of ROOT HAIR DEFECTIVE3 suppress root waving, skewing, and epidermal cell file rotation in Arabidopsis. Yuen CY, et al. Plant Physiol, 2005 Jun. PMID 15908600, Free PMC Article
    4. Efficient ER Fusion Requires a Dimerization and a C-Terminal Tail Mediated Membrane Anchoring of RHD3. Sun J, et al. Plant Physiol, 2018 Jan. PMID 29138354, Free PMC Article
    5. Regulation of the cell expansion gene RHD3 during Arabidopsis development. Wang H, et al. Plant Physiol, 2002 Jun. PMID 12068108, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis reticulons inhibit ROOT HAIR DEFECTIVE3 to form a stable tubular endoplasmic reticulum network.
      Title: Arabidopsis reticulons inhibit ROOT HAIR DEFECTIVE3 to form a stable tubular endoplasmic reticulum network.
    2. LUNAPARK Is an E3 Ligase That Mediates Degradation of ROOT HAIR DEFECTIVE3 to Maintain a Tubular ER Network in Arabidopsis.
      Title: LUNAPARK Is an E3 Ligase That Mediates Degradation of ROOT HAIR DEFECTIVE3 to Maintain a Tubular ER Network in Arabidopsis.
    3. Armadillo-repeat kinesin1 interacts with Arabidopsis atlastin RHD3 to move ER with plus-end of microtubules.
      Title: Armadillo-repeat kinesin1 interacts with Arabidopsis atlastin RHD3 to move ER with plus-end of microtubules.
    4. Turnip Mosaic Virus 6K2 protein physically interacts with RHD3 protein, and redirects RHD3 from the endoplasmic reticulum to viral replication vesicles.Turnip Mosaic Virus replication vesicles requires RHD3 for efficient viral replication and movement.
      Title: A Host ER Fusogen Is Recruited by Turnip Mosaic Virus for Maturation of Viral Replication Vesicles.
    5. This work contributes to a better understanding of a coordinated action of RHD3 in the fusion of endoplasmic reticulum membranes.
      Title: Efficient ER Fusion Requires a Dimerization and a C-Terminal Tail Mediated Membrane Anchoring of RHD3.
    6. RHD3 is required for the formation of a fine endoplasmic reticulum structure in the subapical zone of growing root hairs.
      Title: A GTPase-Dependent Fine ER Is Required for Localized Secretion in Polarized Growth of Root Hairs1.
    7. phosphorylation-stimulated oligomerization of RHD3 enhances endoplasmic reticulum (ER) membrane fusion to form the ER network.
      Title: Phosphorylation of the C Terminus of RHD3 Has a Critical Role in Homotypic ER Membrane Fusion in Arabidopsis.
    8. and function. RHD3 was initially identified as a gene involved in root hair development. This study uncovered a new physiological function of RHD3 in nitrogen starvation-induced anthocyanin accumulation and ethylene homeostasis.
      Title: Arabidopsis ROOT HAIR DEFECTIVE3 is involved in nitrogen starvation-induced anthocyanin accumulation.
    9. We analyzed the lipid fraction of rhd3 mutants at qualitative and quantitative levels. We observed an increase of the amount of phospholipids but also of proteins in the mutants, indicating an overall increase of ER membranes.
      Title: Phospholipid biosynthesis increases in RHD3-defective mutants.
    10. required for the unfolded protein response, an essential endoplasmic reticulum signaling pathway
      Title: ER stress signaling requires RHD3, a functionally conserved ER-shaping GTPase.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_112241.4
    NM_202579.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell tip growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    Root hair defective 3 GTP-binding protein (RHD3)
    NP_188003.1
    • ROOT HAIR DEFECTIVE 3 (RHD3); FUNCTIONS IN: GTP binding; INVOLVED IN: root epidermal cell differentiation, plant-type cell wall biogenesis, ER to Golgi vesicle-mediated transport, actin cytoskeleton organization, cell tip growth; LOCATED IN: endoplasmic reticulum, plasma membrane, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Root hair defective 3 GTP-binding (InterPro:IPR008803); BEST Arabidopsis thaliana protein match is: Root hair defective 3 GTP-binding protein (RHD3) (TAIR:AT1G72960.1); Has 563 Blast hits to 546 proteins in 189 species: Archae - 0; Bacteria - 2; Metazoa - 79; Fungi - 191; Plants - 135; Viruses - 0; Other Eukaryotes - 156 (source: NCBI BLink).
    NP_974308.1
    • ROOT HAIR DEFECTIVE 3 (RHD3); FUNCTIONS IN: GTP binding; INVOLVED IN: root epidermal cell differentiation, plant-type cell wall biogenesis, ER to Golgi vesicle-mediated transport, actin cytoskeleton organization, cell tip growth; LOCATED IN: endoplasmic reticulum, plasma membrane, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Root hair defective 3 GTP-binding (InterPro:IPR008803); BEST Arabidopsis thaliana protein match is: Root hair defective 3 GTP-binding protein (RHD3) (TAIR:AT1G72960.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4565370..4571355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112241.4 → NP_188003.1  Root hair defective 3 GTP-binding protein (RHD3) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188003.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P93042, Q0WL83, Q3EB66
      UniProtKB/TrEMBL
      A0A178VD05, A0A5S9XBX4
      Conserved Domains (1) summary
      pfam05879
      Location:43 → 781
      RHD3; Root hair defective 3 GTP-binding protein (RHD3)

    2. NM_202579.1 → NP_974308.1  Root hair defective 3 GTP-binding protein (RHD3) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974308.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VD05, A0A5S9XBX4
      Conserved Domains (1) summary
      cl21455
      Location:4 → 717
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P93042.1

    Gene LinkOut

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