MSL3 MSCS-like 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MSL3
Official Full Name: MSCS-like 3
Primary source: TAIR:AT1G58200
Locus tag: AT1G58200
See related: Araport:AT1G58200
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F16M22.2; F16M22_2; MSCS-like 3
Summary: A member of MscS-like gene family, structurally very similar to MSL2, comprising of an N-terminal chloroplast transit peptide, five trans-membrane helices and a C-terminal cytoplasmic domain. Mutant plants showed abnormalities in the size and shape of plastids. MSL3-GFP was localized to discrete foci on the plastid envelope and co-localize with the plastid division protein AtMinE. MSL3 was capable of increasing the osmotic-shock survival of a mutant bacterial strain lacking MS-ion-channel activity.
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Genomic context

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See MSL3 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 14

Sequence:: Chromosome: 1; NC_003070.9 (21548140..21553266, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MSL2, MSL3, and components of the Min system function in the same pathway to regulate chloroplast size and FtsZ ring formation.
Title: Two mechanosensitive channel homologs influence division ring placement in Arabidopsis chloroplasts.
We conclude that plastids are under hypoosmotic stress during normal plant growth and dynamic response to this stress requires MSL2 and MSL3.
Title: Mechanosensitive channels protect plastids from hypoosmotic stress during normal plant growth.
Two MscS-like proteins, MSL2 and MSL3, alter ion flux in response to changes in membrane tension to regulate plastid size, shape, and perhaps division during normal plant development. [MSL3]
Title: MscS-like proteins control plastid size and shape in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_104601.2

Supported by ESTs:

NM_202317.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables monoatomic ion channel activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloroplast fission	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within plastid organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in plastid envelope	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: MSCS-like 3

NP_176116.2

MSCS-like 3 (MSL3); FUNCTIONS IN: ion channel activity; INVOLVED IN: plastid organization, response to osmotic stress; LOCATED IN: membrane, plastid envelope; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Mechanosensitive ion channel MscS (InterPro:IPR006685), Like-Sm ribonucleoprotein (LSM)-related domain (InterPro:IPR010920); BEST Arabidopsis thaliana protein match is: MSCS-like 2 (TAIR:AT5G10490.1); Has 6506 Blast hits to 5934 proteins in 1329 species: Archae - 154; Bacteria - 2583; Metazoa - 875; Fungi - 404; Plants - 332; Viruses - 16; Other Eukaryotes - 2142 (source: NCBI BLink).

NP_974046.1

MSCS-like 3 (MSL3); FUNCTIONS IN: ion channel activity; INVOLVED IN: plastid organization, response to osmotic stress; LOCATED IN: membrane, plastid envelope; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Mechanosensitive ion channel MscS (InterPro:IPR006685), Like-Sm ribonucleoprotein (LSM)-related domain (InterPro:IPR010920); BEST Arabidopsis thaliana protein match is: MSCS-like 2 (TAIR:AT5G10490.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

21548140..21553266 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_202317.3 → NP_974046.1 MSCS-like 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974046.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8L7W1, Q9C6R0, Q9C731

UniProtKB/TrEMBL

A0A5S9WQQ2, A0A654EKM2, A0A7G2E1T4

Conserved Domains (2) summary

PHA03151
Location:464 → 624

PHA03151; hypothetical protein; Provisional

cl39057
Location:248 → 450

MS_channel; Mechanosensitive ion channel
NM_104601.2 → NP_176116.2 MSCS-like 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176116.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8L7W1, Q9C6R0, Q9C731

UniProtKB/TrEMBL

A0A5S9WQQ2, A0A654EKM2, A0A7G2E1T4

Conserved Domains (2) summary

PHA03151
Location:464 → 624

PHA03151; hypothetical protein; Provisional

cl39057
Location:248 → 450

MS_channel; Mechanosensitive ion channel