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    MBD3 methyl-CPG-binding domain 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828069, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MBD3
    Official Full Name
    methyl-CPG-binding domain 3
    Primary source
    TAIR:AT4G00416
    Locus tag
    AT4G00416
    See related
    Araport:AT4G00416
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    methyl-CPG-binding domain 3
    Summary
    Protein containing methyl-CpG-binding domain.Has sequence similarity to human MBD proteins.
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    Genomic context

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    See MBD3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_003075.7 (179022..179513)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene Double-stranded RNA-binding domain (DsRBD)-containing protein Neighboring gene plasma membrane intrinsic protein 1;4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MBD3 Regulates Male Germ Cell Division and Sperm Fertility in Arabidopsis thaliana. Shu J, et al. Plants (Basel), 2023 Jul 15. PMID 37514268, Free PMC Article
    2. Characterization of Arabidopsis thaliana methyl-CpG-binding domain (MBD) proteins. Zemach A, et al. Plant J, 2003 Jun. PMID 12787239
    3. CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Wanamaker SA, et al. Nat Methods, 2017 Aug. PMID 28650476, Free PMC Article
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_116266.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables methyl-CpG binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of NuRD complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    methyl-CPG-binding domain 3
    NP_567177.1
    • methyl-CPG-binding domain 3 (MBD3); FUNCTIONS IN: methyl-CpG binding, DNA binding; INVOLVED IN: biological_process unknown; LOCATED IN: nucleus; CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Methyl-CpG DNA binding (InterPro:IPR001739), Zinc finger, CW-type (InterPro:IPR011124); BEST Arabidopsis thaliana protein match is: methyl-CPG-binding domain 4 (TAIR:AT3G63030.1); Has 103 Blast hits to 103 proteins in 14 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 103; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      179022..179513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116266.1 → NP_567177.1  methyl-CPG-binding domain 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567177.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4PSK1
      UniProtKB/TrEMBL
      A0A178UZ94, A0A5S9XNJ6
      Conserved Domains (1) summary
      cd01396
      Location:70 → 134
      MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4PSK1.1

    Gene LinkOut

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