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    EIF3A eukaryotic translation initiation factor 3A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826746, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EIF3A
    Official Full Name
    eukaryotic translation initiation factor 3A
    Primary source
    TAIR:AT4G11420
    Locus tag
    AT4G11420
    See related
    Araport:AT4G11420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATEIF3A-1; ATTIF3A1; EIF3A-1; eukaryotic translation initiation factor 3A; F25E4.40; F25E4_40; TIF3A1
    Summary
    Encodes a subunit of eukaryotic initiation factor 3 (eIF3), a multisubunit complex that is required for binding of mRNA to 40 S ribosomal subunits, stabilization of ternary complex binding to 40 S subunits, and dissociation of 40 and 60 S subunits.
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    Genomic context

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    See EIF3A in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    14
    Sequence:
    Chromosome: 4; NC_003075.7 (6947476..6952479, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new plant protein interacts with eIF3 and 60S to enhance virus-activated translation re-initiation. Thiébeauld O, et al. EMBO J, 2009 Oct 21. PMID 19745810, Free PMC Article
    2. Plant initiation factor 3 subunit composition resembles mammalian initiation factor 3 and has a novel subunit. Burks EA, et al. J Biol Chem, 2001 Jan 19. PMID 11042177
    3. Translational regulation via 5' mRNA leader sequences revealed by mutational analysis of the Arabidopsis translation initiation factor subunit eIF3h. Kim TH, et al. Plant Cell, 2004 Dec. PMID 15548739, Free PMC Article
    4. Characterization of a phosphatase 2C protein as an interacting partner of the histone acetyltransferase GCN5 in Arabidopsis. Servet C, et al. Biochim Biophys Acta, 2008 Jun-Jul. PMID 18498779
    5. In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings. Reichel M, et al. Plant Cell, 2016 Oct. PMID 27729395, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_117213.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within translational initiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    part_of eukaryotic translation initiation factor 3 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3A
    NP_192881.1
    • eukaryotic translation initiation factor 3A (EIF3A); FUNCTIONS IN: translation initiation factor activity; INVOLVED IN: translational initiation; LOCATED IN: eukaryotic translation initiation factor 3 complex, plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Proteasome component (PCI) domain (InterPro:IPR000717); BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT4G23330.1); Has 151795 Blast hits to 76455 proteins in 3156 species: Archae - 1231; Bacteria - 22686; Metazoa - 70860; Fungi - 11049; Plants - 6472; Viruses - 438; Other Eukaryotes - 39059 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      6947476..6952479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117213.4 → NP_192881.1  eukaryotic translation initiation factor 3A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192881.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LD55
      UniProtKB/TrEMBL
      A0A178V400, A0A654FN84, Q0WW10
      Conserved Domains (2) summary
      PTZ00121
      Location:559 → 841
      PTZ00121; MAEBL; Provisional
      pfam01399
      Location:434 → 509
      PCI; PCI domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LD55.1

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