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    ATCES1 Alkaline phytoceramidase (aPHC) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828328, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATCES1
    Official Full Name
    Alkaline phytoceramidase (aPHC)
    Primary source
    TAIR:AT4G22330
    Locus tag
    AT4G22330
    See related
    Araport:AT4G22330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T10I14.160; T10I14_160
    Summary
    Encodes AtCES1 for Acyl-CoA independent ceramide synthase.
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    Genomic context

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    See ATCES1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (11797548..11799946)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein family (UPF0041) Neighboring gene golgin family A protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene microRNA ath-MIR8176 precursor Neighboring gene cytidinediphosphate diacylglycerol synthase 2 Neighboring gene Ubiquitin C-terminal hydrolases superfamily protein Neighboring gene SWIB complex BAF60b domain-containing protein Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of alkaline ceramidase inhibits autophagy in Arabidopsis and plays an important role during environmental stress response. Zheng P, et al. Plant Cell Environ, 2018 Apr. PMID 29341143
    2. The Arabidopsis ceramidase AtACER functions in disease resistance and salt tolerance. Wu JX, et al. Plant J, 2015 Mar. PMID 25619405
    3. Systematic analysis of protein subcellular localization and interaction using high-throughput transient transformation of Arabidopsis seedlings. Marion J, et al. Plant J, 2008 Oct. PMID 18643979
    4. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Parsons HT, et al. Plant Physiol, 2012 May. PMID 22430844, Free PMC Article
    5. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_118359.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ceramide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to other organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to molecule of fungal origin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nutrient levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wax biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Alkaline phytoceramidase (aPHC)
    NP_567660.1
    • ATCES1; FUNCTIONS IN: catalytic activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; INVOLVED IN: ceramide metabolic process; LOCATED IN: endoplasmic reticulum, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ceramidase (InterPro:IPR008901); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11797548..11799946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118359.4 → NP_567660.1  Alkaline phytoceramidase (aPHC) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567660.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49638, Q94IB9
      UniProtKB/TrEMBL
      A0A178UXI2, A0A5S9XUW4
      Conserved Domains (1) summary
      pfam05875
      Location:7 → 247
      Ceramidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94IB9.1

    Gene LinkOut

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