NBR1 ubiquitin-associated (UBA)/TS-N domain-containing protein / octicosapeptide/Phox/Bemp1 (PB1) domain-containing protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: NBR1
Official Full Name: ubiquitin-associated (UBA)/TS-N domain-containing protein / octicosapeptide/Phox/Bemp1 (PB1) domain-containing protein
Primary source: TAIR:AT4G24690
Locus tag: AT4G24690
See related: Araport:AT4G24690
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: Arabidopsis thaliana next to BRCA1 gene 1; AtNBR1; F22K18.110; F22K18_110; next to BRCA1 gene 1
Summary: Encodes NBR1, a selective autophagy substrate.
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Genomic context

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See NBR1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 7

Sequence:: Chromosome: 4; NC_003075.7 (12741032..12744670)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LSU family members and NBR1 are novel factors that contribute to homeostasis of catalases and peroxisomes in Arabidopsis thaliana.
Title: LSU family members and NBR1 are novel factors that contribute to homeostasis of catalases and peroxisomes in Arabidopsis thaliana.
NBR1-mediated selective autophagy of ARF7 modulates root branching.
Title: NBR1-mediated selective autophagy of ARF7 modulates root branching.
NBR1-mediated selective chloroplast autophagy is important to plant stress tolerance.
Title: NBR1-mediated selective chloroplast autophagy is important to plant stress tolerance.
Selective autophagy regulates heat stress memory in Arabidopsis by NBR1-mediated targeting of HSP90.1 and ROF1.
Title: Selective autophagy regulates heat stress memory in Arabidopsis by NBR1-mediated targeting of HSP90.1 and ROF1.
AtNBR1 Is a Selective Autophagic Receptor for AtExo70E2 in Arabidopsis.
Title: AtNBR1 Is a Selective Autophagic Receptor for AtExo70E2 in Arabidopsis.
Arabidopsis cargo receptor NBR1 mediates selective autophagy of defective proteins.
Title: Arabidopsis cargo receptor NBR1 mediates selective autophagy of defective proteins.
Cryo-electron microscopy revealed NBR1 helical structure and polymerization.
Title: Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake.
Selective autophagy limits cauliflower mosaic virus infection by NBR1-mediated targeting of viral capsid protein and particles.
Title: Selective autophagy limits cauliflower mosaic virus infection by NBR1-mediated targeting of viral capsid protein and particles.
These results suggest that NBR1-mediated autophagy targets ubiquitinated protein aggregates most likely derived from denatured or otherwise damaged nonnative proteins generated under stress conditions. [NBR1]
Title: NBR1-mediated selective autophagy targets insoluble ubiquitinated protein aggregates in plant stress responses.
we propose that CHIP and NBR1 mediate two distinct but complementary anti-proteotoxic pathways and protein's propensity to aggregate under stress conditions is one of the critical factors for pathway selection of protein degradation
Title: E3 ubiquitin ligase CHIP and NBR1-mediated selective autophagy protect additively against proteotoxicity in plant stress responses.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_118602.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein polymerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein targeting to vacuole involved in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in vacuole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ubiquitin-associated (UBA)/TS-N domain-containing protein / octicosapeptide/Phox/Bemp1 (PB1) domain-containing protein

NP_194200.1

ubiquitin-associated (UBA)/TS-N domain-containing protein / octicosapeptide/Phox/Bemp1 (PB1) domain-containing protein; FUNCTIONS IN: zinc ion binding; INVOLVED IN: biological_process unknown; LOCATED IN: cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Octicosapeptide/Phox/Bem1p (InterPro:IPR000270), Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), Zinc finger, ZZ-type (InterPro:IPR000433); Has 643 Blast hits to 609 proteins in 134 species: Archae - 0; Bacteria - 9; Metazoa - 374; Fungi - 110; Plants - 97; Viruses - 0; Other Eukaryotes - 53 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

12741032..12744670

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118602.4 → NP_194200.1 ubiquitin-associated (UBA)/TS-N domain-containing protein / octicosapeptide/Phox/Bemp1 (PB1) domain-containing protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194200.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SB64

UniProtKB/TrEMBL

A0A5S9XVM1, A0A654FSE4

Conserved Domains (4) summary

cd06398
Location:8 → 94

PB1_Joka2; The PB1 domain is present in the Nicotiana plumbaginifolia Joka2 protein which interacts with sulfur stress inducible UP9 protein. The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell ...

cd14319
Location:660 → 698

UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins

cd14947
Location:374 → 487

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

cl00295
Location:289 → 331

ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...