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    GLB3 hemoglobin 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829404, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLB3
    Official Full Name
    hemoglobin 3
    Primary source
    TAIR:AT4G32690
    Locus tag
    AT4G32690
    See related
    Araport:AT4G32690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS HEMOGLOBIN 3; ATGLB3; F4D11.1; hemoglobin 3
    Summary
    Encodes a hemoglobin (Hb) with a central domain similar to the 'truncated Hbs of bacteria, protozoa and fungi. The 3D structure of these types of Hbs is a 2-on-2 arrangement of alpha-helices as opposed to the 3-on-3 arrangement of the standard globin fold. This type of Hb is not found in animals or yeast.
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    Genomic context

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    See GLB3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (15765112..15767106)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein kinase superfamily protein Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene uncharacterized protein Neighboring gene MUS308 and mammalian DNA polymerase-like protein Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The structure of a class 3 nonsymbiotic plant haemoglobin from Arabidopsis thaliana reveals a novel N-terminal helical extension. Reeder BJ, et al. Acta Crystallogr D Biol Crystallogr, 2014 May. PMID 24816109
    2. A hemoglobin from plants homologous to truncated hemoglobins of microorganisms. Watts RA, et al. Proc Natl Acad Sci U S A, 2001 Aug 28. PMID 11526234, Free PMC Article
    3. The Arabidopsis Iron-Sulfur Protein GRXS17 is a Target of the Ubiquitin E3 Ligases RGLG3 and RGLG4. Nagels Durand A, et al. Plant Cell Physiol, 2016 Sep. PMID 27497447
    4. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article
    5. Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, et al. Plant Cell, 2023 Mar 15. PMID 36660928, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119421.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen carrier activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within oxygen transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    hemoglobin 3
    NP_567901.1
    • hemoglobin 3 (GLB3); CONTAINS InterPro DOMAIN/s: Globin, truncated bacterial-like (InterPro:IPR001486), Globin-like (InterPro:IPR009050), Globin (InterPro:IPR012292); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15765112..15767106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119421.5 → NP_567901.1  hemoglobin 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567901.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65532, Q67XG0, Q946U7
      UniProtKB/TrEMBL
      A0A178V2G3, A0A5S9XYG3
      Conserved Domains (1) summary
      cd19755
      Location:28 → 146
      TrHb2_AtGlb3-like_O; nonsymbiotic haemoglobin Ahb3 (GLB3) and similar truncated hemoglobins, group 2 (O)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q67XG0.1

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