NIT3 nitrilase 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: NIT3
Official Full Name: nitrilase 3
Primary source: TAIR:AT3G44320
Locus tag: AT3G44320
See related: Araport:AT3G44320
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtNIT3; nitrilase 3; NITRILASE 3
Summary: This enzyme catalyzes the hydrolysis of indole-3-acetonitrile (IAN) to indole-3-acetic acid (IAA) (EC 3.5.5.1) and IAN to indole-3-acetamide (IAM) at lower levels. It is the only one of the four Arabidopsis nitrilases whose mRNA levels are strongly induced when plants experience sulphur deprivation. This enzyme likely participates in other non-auxin-related metabolic pathways.
NEW: Try the new Gene table
Try the new Transcript table

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_114300.4

Function	Evidence Code	Pubs
enables indole-3-acetonitrile nitrilase activity	IDA Inferred from Direct Assay more info	PubMed
enables indole-3-acetonitrile nitrile hydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nitrilase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to sulfate starvation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within glucosinolate catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

NP_190018.1

nitrilase 3 (NIT3); FUNCTIONS IN: indole-3-acetonitrile nitrilase activity, nitrilase activity, indole-3-acetonitrile nitrile hydratase activity; INVOLVED IN: cellular response to sulfate starvation, response to cadmium ion, glucosinolate catabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase (InterPro:IPR003010), Nitrilase/cyanide hydratase, conserved site (InterPro:IPR000132); BEST Arabidopsis thaliana protein match is: nitrilase 1 (TAIR:AT3G44310.3); Has 7365 Blast hits to 7291 proteins in 1693 species: Archae - 150; Bacteria - 4836; Metazoa - 437; Fungi - 564; Plants - 330; Viruses - 11; Other Eukaryotes - 1037 (source: NCBI BLink).