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    RHL2 Spo11/DNA topoisomerase VI, subunit A protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831314, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RHL2
    Official Full Name
    Spo11/DNA topoisomerase VI, subunit A protein
    Primary source
    TAIR:AT5G02820
    Locus tag
    AT5G02820
    See related
    Araport:AT5G02820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BIN5; BRASSINOSTEROID INSENSITIVE 5; F9G14.130; F9G14_130; ROOT HAIRLESS 2; SPO11-3
    Summary
    Involved in the patterning and shape of leaf trichomes. Encodes the DNA topoisomerase VI SPO11-3, involved in endoreduplication
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    Genomic context

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    See RHL2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (642554..644394)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo-response regulator 7 Neighboring gene tRNA-Ser Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ncRNA Neighboring gene LHY/CCA1-like 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Integration of stress-related and reactive oxygen species-mediated signals by Topoisomerase VI in Arabidopsis thaliana. Simková K, et al. Proc Natl Acad Sci U S A, 2012 Oct 2. PMID 22988090, Free PMC Article
    2. DNA topoisomerase VI is essential for endoreduplication in Arabidopsis. Sugimoto-Shirasu K, et al. Curr Biol, 2002 Oct 15. PMID 12401175
    3. Molecular characterization of homologues of both subunits A (SPO11) and B of the archaebacterial topoisomerase 6 in plants. Hartung F, et al. Gene, 2001 Jun 13. PMID 11410368
    4. MIDGET unravels functions of the Arabidopsis topoisomerase VI complex in DNA endoreduplication, chromatin condensation, and transcriptional silencing. Kirik V, et al. Plant Cell, 2007 Oct. PMID 17951446, Free PMC Article
    5. RHL1 is an essential component of the plant DNA topoisomerase VI complex and is required for ploidy-dependent cell growth. Sugimoto-Shirasu K, et al. Proc Natl Acad Sci U S A, 2005 Dec 20. PMID 16339310, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Topo VI acts as an integrator of multiple signals generated by reactive oxygen species formed under adverse environmental conditions.
      Title: Integration of stress-related and reactive oxygen species-mediated signals by Topoisomerase VI in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_120360.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within plant epidermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Spo11/DNA topoisomerase VI, subunit A protein
    NP_195902.1
    • ROOT HAIRLESS 2 (RHL2); CONTAINS InterPro DOMAIN/s: Spo11/DNA topoisomerase VI, subunit A, N-terminal (InterPro:IPR013049), DNA topoisomerase VI, subunit A (InterPro:IPR004085), Spo11/DNA topoisomerase VI, subunit A (InterPro:IPR002815); BEST Arabidopsis thaliana protein match is: Spo11/DNA topoisomerase VI, subunit A protein (TAIR:AT3G13170.1); Has 936 Blast hits to 932 proteins in 314 species: Archae - 223; Bacteria - 16; Metazoa - 170; Fungi - 119; Plants - 152; Viruses - 0; Other Eukaryotes - 256 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      642554..644394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120360.4 → NP_195902.1  Spo11/DNA topoisomerase VI, subunit A protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195902.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LZ03
      UniProtKB/TrEMBL
      A0A178UQD3, A0A5S9Y1I0
      Conserved Domains (1) summary
      PRK04342
      Location:91 → 427
      PRK04342; DNA topoisomerase IV subunit A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LZ03.1

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