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    MSL10 mechanosensitive channel of small conductance-like 10 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831081, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MSL10
    Official Full Name
    mechanosensitive channel of small conductance-like 10
    Primary source
    TAIR:AT5G12080
    Locus tag
    AT5G12080
    See related
    Araport:AT5G12080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMSL10; F14F18.230; F14F18_230; mechanosensitive channel of small conductance-like 10
    Summary
    Encodes a mechanosensitive (or stretch-activated) ion channel in the plasma membrane with a moderate preference for anions.
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    Genomic context

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    See MSL10 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (3897893..3901790, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Plant self-incompatibility protein S1 family Neighboring gene Plant self-incompatibility protein S1 family Neighboring gene pseudo Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Open structure and gating of the Arabidopsis mechanosensitive ion channel MSL10. Zhang J, et al. Nat Commun, 2023 Oct 7. PMID 37805510, Free PMC Article
    2. The Mechanosensitive Ion Channel MSL10 Modulates Susceptibility to Pseudomonas syringae in Arabidopsis thaliana. Basu D, et al. Mol Plant Microbe Interact, 2022 Jul. PMID 34775835
    3. Interactions between the N- and C-termini of the mechanosensitive ion channel AtMSL10 are consistent with a three-step mechanism for activation. Basu D, et al. J Exp Bot, 2020 Jul 6. PMID 32280992
    4. A gain-of-function mutation in Msl10 triggers cell death and wound-induced hyperaccumulation of jasmonic acid in Arabidopsis. Zou Y, et al. J Integr Plant Biol, 2016 Jun. PMID 26356550
    5. Arabidopsis MSL10 has a regulated cell death signaling activity that is separable from its mechanosensitive ion channel activity. Veley KM, et al. Plant Cell, 2014 Jul. PMID 25052715, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Open structure and gating of the Arabidopsis mechanosensitive ion channel MSL10.
      Title: Open structure and gating of the Arabidopsis mechanosensitive ion channel MSL10.
    2. The Mechanosensitive Ion Channel MSL10 Modulates Susceptibility to Pseudomonas syringae in Arabidopsis thaliana.
      Title: The Mechanosensitive Ion Channel MSL10 Modulates Susceptibility to Pseudomonas syringae in Arabidopsis thaliana.
    3. Interactions between the N- and C-termini of the mechanosensitive ion channel AtMSL10 are consistent with a three-step mechanism for activation.
      Title: Interactions between the N- and C-termini of the mechanosensitive ion channel AtMSL10 are consistent with a three-step mechanism for activation.
    4. Studies provide evidence that MSL10 and DEK1 are associated with two distinct mechanosensitive (MS) channel activities. MSL10 mediates large fluxes of anions while DEK1 mediates small fluxes of calcium. MSL10 and DEK1 encode bifunctional proteins whose cytosolic domain functioning differently from the MS channel. [review]
      Title: Sensing and transducing forces in plants with MSL10 and DEK1 mechanosensors.
    5. results suggest that MSL10 is involved in the wound-triggered early signal transduction pathway and possibly in regulating the positive feedback synthesis of JA.
      Title: A gain-of-function mutation in Msl10 triggers cell death and wound-induced hyperaccumulation of jasmonic acid in Arabidopsis.
    6. The plant-specific N-terminal domain of MSL10 is capable of inducing cell death, this activity is regulated by phosphorylation, and MSL10 has two separable activities-one as an ion channel and one as an inducer of cell death.
      Title: Arabidopsis MSL10 has a regulated cell death signaling activity that is separable from its mechanosensitive ion channel activity.
    7. MSL10 demonstrated asymmetric activation/inactivation kinetics, with the channel closing at substantially lower tensions than channel opening.
      Title: MscS-Like10 is a stretch-activated ion channel from Arabidopsis thaliana with a preference for anions.
    8. MSL9 and MSL10 are required for mechanosensitive channel activities detected in protoplasts derived from root cells. [MSL10]
      Title: Two MscS homologs provide mechanosensitive channel activities in the Arabidopsis root.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001125740.2
    NM_121246.5
    NM_180479.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mechanosensitive monoatomic ion channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within detection of mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic anion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within programmed cell death in response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mechanosensitive channel of small conductance-like 10
    NP_001119212.1
    • mechanosensitive channel of small conductance-like 10 (MSL10); FUNCTIONS IN: mechanically-gated ion channel activity; INVOLVED IN: detection of mechanical stimulus; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Membrane protein, At2g17000, predicted (InterPro:IPR016688), Like-Sm ribonucleoprotein (LSM)-related domain (InterPro:IPR010920), Mechanosensitive ion channel MscS (InterPro:IPR006685); BEST Arabidopsis thaliana protein match is: mechanosensitive channel of small conductance-like 9 (TAIR:AT5G19520.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_196769.1
    • mechanosensitive channel of small conductance-like 10 (MSL10); FUNCTIONS IN: mechanically-gated ion channel activity; INVOLVED IN: detection of mechanical stimulus; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Membrane protein, At2g17000, predicted (InterPro:IPR016688), Mechanosensitive ion channel MscS (InterPro:IPR006685), Like-Sm ribonucleoprotein (LSM)-related domain (InterPro:IPR010920); BEST Arabidopsis thaliana protein match is: mechanosensitive channel of small conductance-like 9 (TAIR:AT5G19520.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_850810.1
    • mechanosensitive channel of small conductance-like 10 (MSL10); FUNCTIONS IN: mechanically-gated ion channel activity; INVOLVED IN: detection of mechanical stimulus; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Membrane protein, At2g17000, predicted (InterPro:IPR016688), Like-Sm ribonucleoprotein (LSM)-related domain (InterPro:IPR010920), Mechanosensitive ion channel MscS (InterPro:IPR006685); BEST Arabidopsis thaliana protein match is: mechanosensitive channel of small conductance-like 9 (TAIR:AT5G19520.1); Has 3162 Blast hits to 3155 proteins in 988 species: Archae - 147; Bacteria - 2129; Metazoa - 0; Fungi - 206; Plants - 206; Viruses - 0; Other Eukaryotes - 474 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      3897893..3901790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001125740.2 → NP_001119212.1  mechanosensitive channel of small conductance-like 10 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119212.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2U6, Q9LYG9
      UniProtKB/TrEMBL
      A0A178U9L6, A0A5S9Y3H0
      Conserved Domains (1) summary
      cl39057
      Location:516 → 720
      MS_channel; Mechanosensitive ion channel

    2. NM_121246.5 → NP_196769.1  mechanosensitive channel of small conductance-like 10 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196769.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2U6, Q9LYG9
      UniProtKB/TrEMBL
      A0A178U9L6, A0A5S9Y3H0
      Conserved Domains (1) summary
      cl39057
      Location:516 → 720
      MS_channel; Mechanosensitive ion channel

    3. NM_180479.2 → NP_850810.1  mechanosensitive channel of small conductance-like 10 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850810.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2U6, Q9LYG9
      UniProtKB/TrEMBL
      A0A178U9L6, A0A5S9Y3H0
      Conserved Domains (1) summary
      cl39057
      Location:516 → 720
      MS_channel; Mechanosensitive ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LYG9.1

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