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    TOP3A topoisomerase 3alpha [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836513, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TOP3A
    Official Full Name
    topoisomerase 3alpha
    Primary source
    TAIR:AT5G63920
    Locus tag
    AT5G63920
    See related
    Araport:AT5G63920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtTOP3alpha; MGI19.16; topoisomerase 3alpha
    Summary
    Encodes topoisomerase 3alpha. Suppresses somatic crossovers. Essential for resolution of meiotic recombination intermediates.
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    Genomic context

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    See TOP3A in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    24
    Sequence:
    Chromosome: 5; NC_003076.8 (25574419..25581433)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene farnesylcysteine lyase Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene kinase with adenine nucleotide alpha hydrolases-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The topoisomerase 3α zinc-finger domain T1 of Arabidopsis thaliana is required for targeting the enzyme activity to Holliday junction-like DNA repair intermediates. Dorn A, et al. PLoS Genet, 2018 Sep. PMID 30222730, Free PMC Article
    2. Topoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thaliana. Hartung F, et al. PLoS Genet, 2008 Dec. PMID 19096507, Free PMC Article
    3. Multiple mechanisms limit meiotic crossovers: TOP3α and two BLM homologs antagonize crossovers in parallel to FANCM. Séguéla-Arnaud M, et al. Proc Natl Acad Sci U S A, 2015 Apr 14. PMID 25825745, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A. thaliana TOP3alpha conserved zinc-finger domain (ZFD) T1 is specifically required for targeting the topoisomerase activity to Holliday junction like recombination intermediates to enable their processing. In the case of an inactivated enzyme, this leads to cell death due to the masking of these intermediates, hindering their resolution by MUS81.
      Title: The topoisomerase 3α zinc-finger domain T1 of Arabidopsis thaliana is required for targeting the enzyme activity to Holliday junction-like DNA repair intermediates.
    2. Data indicate that both topoisomerase3alpha (TOP3alpha) and RECQ4A/B helicases act independently of the anti-meiotic crossovers (COs) Fanconi anemia of complementation group M (FANCM) helicase.
      Title: Multiple mechanisms limit meiotic crossovers: TOP3α and two BLM homologs antagonize crossovers in parallel to FANCM.
    3. AtTOP3alpha and AtRMI1 are involved in the suppression of crossover recombination in somatic cells and DNA repair.
      Title: Topoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    NM_125788.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA topological change IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within resolution of meiotic recombination intermediates IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    topoisomerase 3alpha
    NP_201197.1
    • topoisomerase 3alpha (TOP3A); FUNCTIONS IN: DNA topoisomerase activity, DNA topoisomerase type I activity, DNA binding, zinc ion binding, nucleic acid binding; INVOLVED IN: in 7 processes; LOCATED IN: chromosome; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA topoisomerase, type IA, zn finger (InterPro:IPR013498), DNA topoisomerase, type IA, core (InterPro:IPR000380), DNA topoisomerase, type IA, domain 2 (InterPro:IPR003601), DNA topoisomerase, type IA, DNA-binding (InterPro:IPR003602), DNA topoisomerase, type IA, central (InterPro:IPR013497), Zinc finger, GRF-type (InterPro:IPR010666), DNA topoisomerase, type IA, central region, subdomain 3 (InterPro:IPR013826), Toprim domain, subgroup (InterPro:IPR006154), DNA topoisomerase, type IA, central region, subdomain 1 (InterPro:IPR013824), Toprim domain (InterPro:IPR006171), Zinc finger, CCHC-type (InterPro:IPR001878); BEST Arabidopsis thaliana protein match is: DNA topoisomerase, type IA, core (TAIR:AT2G32000.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25574419..25581433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125788.7 → NP_201197.1  topoisomerase 3alpha [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201197.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LVP1
      UniProtKB/TrEMBL
      A0A5S9YGZ2, A0A654GDT9
      Conserved Domains (2) summary
      PRK07219
      Location:10 → 702
      PRK07219; DNA topoisomerase I; Validated
      pfam06839
      Location:804 → 844
      zf-GRF; GRF zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LVP1.1

    Gene LinkOut

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