EB1C end binding protein 1C [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: EB1C
Official Full Name: end binding protein 1C
Primary source: TAIR:AT5G67270
Locus tag: AT5G67270
See related: Araport:AT5G67270
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATEB1-HOMOLOG1; ATEB1C; ATEB1H1; end binding protein 1C; K3G17.3; K3G17_3; MICROTUBULE END BINDING PROTEIN 1
Summary: encodes a homolog of animal microtubule-end-binding protein. There are two other members of this family. EB1 forms foci at regions where the minus ends of microtubules are gathered during mitosis and early cytokinesis.
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Genomic context

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See EB1C in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 6

Sequence:: Chromosome: 5; NC_003076.8 (26840011..26842104, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MPK6 phosphorylates EB1c, but not EB1a, and has a role in maintaining regular planes of cell division under stress conditions.
Title: The Arabidopsis mitogen-activated protein kinase 6 is associated with γ-tubulin on microtubules, phosphorylates EB1c and maintains spindle orientation under nitrosative stress.
Data find that antibodies directed against EB1C proteins colocalize with microtubules in roots, and that mutants with reduced expression from EB1 genes have roots that deviate toward the left on vertical or inclined plates.
Title: The microtubule plus-end binding protein EB1 functions in root responses to touch and gravity signals in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_126127.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cortical cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within thigmotropism	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in nucleolus	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in phragmoplast	HDA more info	PubMed
located_in plant-type cell wall	HDA more info	PubMed
located_in spindle	HDA more info	PubMed

General protein information

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Preferred Names: end binding protein 1C

NP_201528.1

end binding protein 1C (EB1C); CONTAINS InterPro DOMAIN/s: Calponin-homology (InterPro:IPR016146), Calponin-like actin-binding (InterPro:IPR001715), EB1, C-terminal (InterPro:IPR004953); BEST Arabidopsis thaliana protein match is: microtubule end binding protein EB1A (TAIR:AT3G47690.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

26840011..26842104 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_126127.4 → NP_201528.1 end binding protein 1C [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_201528.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FGQ6

UniProtKB/TrEMBL

A0A178UNG3, A0A5S9YJT3, A0A7G2FJF3

Conserved Domains (1) summary

COG5217
Location:8 → 261

BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]