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    GPDHC1 6-phosphogluconate dehydrogenase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818752, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GPDHC1
    Official Full Name
    6-phosphogluconate dehydrogenase family protein
    Primary source
    TAIR:AT2G41540
    Locus tag
    AT2G41540
    See related
    Araport:AT2G41540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T32G6.6; T32G6_6
    Summary
    Encodes a protein with NAD-dependent glycerol-3-phosphate (G3P) dehydrogenase which was shown to complement an Escherichia coli strain: BB20-14, auxotrophic for glycerol/G3P due to a loss-of-function mutation in the gpsA gene.
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    Genomic context

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    See GPDHC1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (17325846..17329235)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Heat shock protein DnaJ with tetratricopeptide repeat-containing protein Neighboring gene S-formylglutathione hydrolase Neighboring gene Rho termination factor Neighboring gene autoinhibited Ca(2+)-ATPase Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of a glycerol-3-phosphate dehydrogenase in modulating the NADH/NAD+ ratio provides evidence of a mitochondrial glycerol-3-phosphate shuttle in Arabidopsis. Shen W, et al. Plant Cell, 2006 Feb. PMID 16415206, Free PMC Article
    2. Glycerol-3-phosphate metabolism in wheat contributes to systemic acquired resistance against Puccinia striiformis f. sp. tritici. Yang Y, et al. PLoS One, 2013. PMID 24312351, Free PMC Article
    3. Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes. Elrouby N, et al. Proc Natl Acad Sci U S A, 2010 Oct 5. PMID 20855607, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036448.2
    NM_129717.5
    NM_180021.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables glycerol-3-phosphate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    6-phosphogluconate dehydrogenase family protein
    NP_001031525.1
    • GPDHC1; CONTAINS InterPro DOMAIN/s: 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), NAD(P)-binding domain (InterPro:IPR016040), NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal (InterPro:IPR006109), NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal (InterPro:IPR011128), NAD-dependent glycerol-3-phosphate dehydrogenase (InterPro:IPR006168); BEST Arabidopsis thaliana protein match is: 6-phosphogluconate dehydrogenase family protein (TAIR:AT3G07690.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_181685.1
    • GPDHC1; CONTAINS InterPro DOMAIN/s: 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), NAD(P)-binding domain (InterPro:IPR016040), NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal (InterPro:IPR006109), NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal (InterPro:IPR011128), NAD-dependent glycerol-3-phosphate dehydrogenase (InterPro:IPR006168); BEST Arabidopsis thaliana protein match is: 6-phosphogluconate dehydrogenase family protein (TAIR:AT3G07690.1); Has 4956 Blast hits to 4956 proteins in 1719 species: Archae - 20; Bacteria - 3172; Metazoa - 444; Fungi - 126; Plants - 154; Viruses - 0; Other Eukaryotes - 1040 (source: NCBI BLink).
    NP_850352.1
    • GPDHC1; CONTAINS InterPro DOMAIN/s: 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), NAD(P)-binding domain (InterPro:IPR016040), NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal (InterPro:IPR006109), NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal (InterPro:IPR011128), NAD-dependent glycerol-3-phosphate dehydrogenase (InterPro:IPR006168); BEST Arabidopsis thaliana protein match is: 6-phosphogluconate dehydrogenase family protein (TAIR:AT3G07690.1); Has 4956 Blast hits to 4956 proteins in 1719 species: Archae - 20; Bacteria - 3172; Metazoa - 444; Fungi - 126; Plants - 154; Viruses - 0; Other Eukaryotes - 1040 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17325846..17329235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336924.1 → NP_001325243.1  6-phosphogluconate dehydrogenase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DH11, O22216
      UniProtKB/TrEMBL
      A0A178VTE6, A0A5S9X634
      Conserved Domains (1) summary
      COG0240
      Location:41 → 433
      GpsA; Glycerol-3-phosphate dehydrogenase [Energy production and conversion]

    2. NM_129717.5 → NP_181685.1  6-phosphogluconate dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181685.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DH11, O22216
      UniProtKB/TrEMBL
      A0A178VTE6, A0A5S9X634
      Conserved Domains (1) summary
      COG0240
      Location:41 → 433
      GpsA; Glycerol-3-phosphate dehydrogenase [Energy production and conversion]

    3. NM_180021.5 → NP_850352.1  6-phosphogluconate dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850352.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DH11, O22216
      UniProtKB/TrEMBL
      A0A178VTE6, A0A5S9X634
      Conserved Domains (1) summary
      COG0240
      Location:41 → 433
      GpsA; Glycerol-3-phosphate dehydrogenase [Energy production and conversion]

    4. NM_001036448.2 → NP_001031525.1  6-phosphogluconate dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031525.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DH11, O22216
      UniProtKB/TrEMBL
      A0A178VTE6, A0A5S9X634
      Conserved Domains (1) summary
      COG0240
      Location:41 → 433
      GpsA; Glycerol-3-phosphate dehydrogenase [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22216.1

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