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    Nectin2 nectin cell adhesion molecule 2 [ Mus musculus (house mouse) ]

    Gene ID: 19294, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nectin2provided by MGI
    Official Full Name
    nectin cell adhesion molecule 2provided by MGI
    Primary source
    MGI:MGI:97822
    See related
    Ensembl:ENSMUSG00000062300 AllianceGenome:MGI:97822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MPH; Pvr; Pvs; Cd112; Pvrl2; nectin-2
    Summary
    Enables cell adhesion molecule binding activity and protein homodimerization activity. Involved in homophilic cell adhesion via plasma membrane adhesion molecules and spermatid development. Acts upstream of or within several processes, including establishment of mitochondrion localization; sperm mitochondrion organization; and spermatid development. Located in cell-cell contact zone; plasma membrane; and zonula adherens. Is expressed in brain; cochlea; enamel organ; male reproductive system; and metanephros. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple sclerosis. Orthologous to human NECTIN2 (nectin cell adhesion molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in duodenum adult (RPKM 62.2), colon adult (RPKM 44.8) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Nectin2 in Genome Data Viewer
    Location:
    7 A3; 7 9.94 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19450569..19483498, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19716644..19749573, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein E Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene predicted gene, 38955 Neighboring gene STARR-seq mESC enhancer starr_18217 Neighboring gene STARR-seq mESC enhancer starr_18218 Neighboring gene predicted gene, 34744 Neighboring gene basal cell adhesion molecule Neighboring gene STARR-seq mESC enhancer starr_18221 Neighboring gene Casitas B-lineage lymphoma c

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in acrosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adhesion of symbiont to host ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular anatomical entity morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cilium organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in coreceptor-mediated virion attachment to host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in coreceptor-mediated virion attachment to host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in coreceptor-mediated virion attachment to host cell ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of mitochondrion localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fusion of virus membrane with host plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fusion of virus membrane with host plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of immunoglobulin mediated immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of immunoglobulin mediated immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of immunoglobulin mediated immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mast cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of mast cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mast cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sperm mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatid nucleus differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in susceptibility to T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in susceptibility to T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in susceptibility to natural killer cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in susceptibility to natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in apical junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical junction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell contact zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in zonula adherens IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nectin-2
    Names
    herpes virus entry mediator B
    herpesvirus entry mediator B
    hveB
    mHveB
    murine herpes virus entry protein B
    murine herpesvirus entry protein B
    poliovirus receptor homolog
    poliovirus receptor-related 2
    poliovirus receptor-related protein 2
    poliovirus sensitivity

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159724.1NP_001153196.1  nectin-2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001153196.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' terminal exon compared to variant 1 that causes a frameshift. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC149282, AK075815, BQ033135
      Consensus CDS
      CCDS52063.1
      UniProtKB/TrEMBL
      Q3TZU9, Q91VT9
      Related
      ENSMUSP00000104089.4, ENSMUST00000108450.5
      Conserved Domains (3) summary
      cd05718
      Location:48150
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      smart00410
      Location:40149
      IG_like; Immunoglobulin like
      cl11960
      Location:153248
      Ig; Immunoglobulin domain
    2. NM_008990.3NP_033016.3  nectin-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_033016.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC149282, BC046770
      Consensus CDS
      CCDS20913.1
      UniProtKB/Swiss-Prot
      P32507, Q62096
      UniProtKB/TrEMBL
      Q80XJ5
      Related
      ENSMUSP00000074898.8, ENSMUST00000075447.14
      Conserved Domains (3) summary
      cd05718
      Location:48150
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      smart00410
      Location:40149
      IG_like; Immunoglobulin like
      cl11960
      Location:153248
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19450569..19483498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)