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    Spn sialophorin [ Mus musculus (house mouse) ]

    Gene ID: 20737, updated on 9-Dec-2024

    Summary

    Official Symbol
    Spnprovided by MGI
    Official Full Name
    sialophorinprovided by MGI
    Primary source
    MGI:MGI:98384
    See related
    Ensembl:ENSMUSG00000051457 AllianceGenome:MGI:98384
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd43; Ly48; Galgp; Ly-48; A630014B01Rik
    Summary
    Enables heat shock protein binding activity. Involved in leukocyte tethering or rolling; negative regulation of T cell proliferation; and positive regulation of T cell migration. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; regulation of T cell activation; and regulation of defense response. Located in basement membrane; external side of plasma membrane; and uropod. Is expressed in hematopoietic system; umbilical artery; vascular system; and yolk sac. Orthologous to human SPN (sialophorin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 26.4), spleen adult (RPKM 15.5) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Spn in Genome Data Viewer
    Location:
    7 F3; 7 69.35 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126731404..126743785, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127123637..127145552, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134234662-134234982 Neighboring gene expressed sequence AI467606 Neighboring gene STARR-positive B cell enhancer ABC_E6604 Neighboring gene quinolinate phosphoribosyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E9301 Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20170 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134332123-134332276 Neighboring gene STARR-positive B cell enhancer ABC_E4977 Neighboring gene CD2 cytoplasmic tail binding protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T-helper 1 cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T-helper 1 cell lineage commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte tethering or rolling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of type IV hypersensitivity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of T cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to protozoan IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in uropod IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    leukosialin
    Names
    3E8 antigen
    B-cell differentiation antigen LP-3
    leukocyte sialoglycoprotein
    lymphocyte antigen 48

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037810.2NP_001032899.1  leukosialin precursor

      See identical proteins and their annotated locations for NP_001032899.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC122537, AK041712, AK134098
      Consensus CDS
      CCDS21858.1
      UniProtKB/Swiss-Prot
      P15702
      UniProtKB/TrEMBL
      Q544C5
      Related
      ENSMUSP00000122787.2, ENSMUST00000143713.2
      Conserved Domains (1) summary
      pfam15782
      Location:100246
      GREB1; Gene regulated by oestrogen in breast cancer
    2. NM_009259.5NP_033285.1  leukosialin precursor

      See identical proteins and their annotated locations for NP_033285.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC122537, AK077764, AK134098, AW540100
      Consensus CDS
      CCDS21858.1
      UniProtKB/Swiss-Prot
      P15702
      UniProtKB/TrEMBL
      Q544C5
      Related
      ENSMUSP00000049534.6, ENSMUST00000049931.6
      Conserved Domains (1) summary
      pfam15782
      Location:100246
      GREB1; Gene regulated by oestrogen in breast cancer

    RNA

    1. NR_110337.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains 2 novel exons at the 3' end compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC122537, AK041480

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126731404..126743785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241716.3XP_011240018.1  leukosialin isoform X1

      See identical proteins and their annotated locations for XP_011240018.1

      Conserved Domains (1) summary
      pfam15782
      Location:115261
      GREB1; Gene regulated by oestrogen in breast cancer
    2. XM_006507522.5XP_006507585.1  leukosialin isoform X2

      See identical proteins and their annotated locations for XP_006507585.1

      UniProtKB/Swiss-Prot
      P15702
      UniProtKB/TrEMBL
      Q544C5
      Conserved Domains (1) summary
      pfam15782
      Location:100246
      GREB1; Gene regulated by oestrogen in breast cancer