Nsg2 neuron specific gene family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nsg2provided by MGI
Official Full Name: neuron specific gene family member 2provided by MGI
Primary source: MGI:MGI:1202070
See related: Ensembl:ENSMUSG00000020297 AllianceGenome:MGI:1202070
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P19
Summary: Predicted to enable clathrin light chain binding activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Located in Golgi cis cisterna membrane and multivesicular body membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including axial skeleton; intestine; nasal epithelium; nervous system; and retina. Orthologous to human NSG2 (neuronal vesicle trafficking associated 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 228.8), whole brain E14.5 (RPKM 160.1) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A4; 11 18.72 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (31949678..32009211)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (31999704..32059211)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NSG2 is found in discrete punctae restricted to the somatodendritic arbors of developing mouse and human neurons, and a significant proportion of NSG2 punctae colocalize with postsynaptic HOMER1 and surface-expressed AMPA-type glutamate receptors (AMPARs) at excitatory synapses.
Title: Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting Protein That Modulates Excitatory Neurotransmission.
we show that NEEP21/Nsg1 and P19/Nsg2 are present in both overlapping and distinct cell populations in the hippocampus, neocortex, and cerebellum during development.
Title: The related neuronal endosomal proteins NEEP21 (Nsg1) and P19 (Nsg2) have divergent expression profiles in vivo.
Fbxl10 is a bona fide oncogene, whose deregulated expression contributes to the development of leukemia involving metabolic proliferative advantage and Nsg2-mediated impaired differentiation.
Title: Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nsg2 (e-PCR), detects polymorphism
- UniSTS:546902

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

AA989750 (e-PCR)
- UniSTS:180169

RH125202 (e-PCR)
- UniSTS:162024

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables clathrin light chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin light chain binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in clathrin coat assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin coat assembly	IEA Inferred from Electronic Annotation more info
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cis cisterna membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosomal lumen	IEA Inferred from Electronic Annotation more info
located_in lysosomal lumen	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in multivesicular body membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: neuronal vesicle trafficking-associated protein 2

Names: neuron-specific protein family member 2; protein 8.5; protein p19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290680.1 → NP_001277609.1 neuronal vesicle trafficking-associated protein 2 isoform 1

See identical proteins and their annotated locations for NP_001277609.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).

Source sequence(s)

AK075612, BM114408, BU058771, CO040919

Consensus CDS

CCDS24516.1

UniProtKB/Swiss-Prot

P47759

UniProtKB/TrEMBL

Q5SS02

Conserved Domains (1) summary

pfam06387
Location:1 → 169

Calcyon; D1 dopamine receptor-interacting protein (calcyon)
NM_001290681.1 → NP_001277610.1 neuronal vesicle trafficking-associated protein 2 isoform 1

See identical proteins and their annotated locations for NP_001277610.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).

Source sequence(s)

AK075612, AL669946, BM114408, CD352422, CO040919

Consensus CDS

CCDS24516.1

UniProtKB/Swiss-Prot

P47759

UniProtKB/TrEMBL

Q5SS02

Conserved Domains (1) summary

pfam06387
Location:1 → 169

Calcyon; D1 dopamine receptor-interacting protein (calcyon)
NM_001347080.1 → NP_001334009.1 neuronal vesicle trafficking-associated protein 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate 3' terminal exon, resulting in novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK041338, DN176718

Consensus CDS

CCDS88140.1

UniProtKB/TrEMBL

Q5SS03

Related

ENSMUSP00000090907.4, ENSMUST00000093219.4

Conserved Domains (1) summary

pfam06387
Location:1 → 74

Calcyon; D1 dopamine receptor-interacting protein (calcyon)
NM_008741.4 → NP_032767.1 neuronal vesicle trafficking-associated protein 2 isoform 1

See identical proteins and their annotated locations for NP_032767.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same isoform (1).

Source sequence(s)

AK075612, BM114408, CO040919, DN176718

Consensus CDS

CCDS24516.1

UniProtKB/Swiss-Prot

P47759

UniProtKB/TrEMBL

Q5SS02

Related

ENSMUSP00000020537.3, ENSMUST00000020537.9

Conserved Domains (1) summary

pfam06387
Location:1 → 169

Calcyon; D1 dopamine receptor-interacting protein (calcyon)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

31949678..32009211

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245647.2 → XP_030101507.1 neuronal vesicle trafficking-associated protein 2 isoform X1

UniProtKB/Swiss-Prot

P47759

UniProtKB/TrEMBL

Q5SS02

Conserved Domains (1) summary

pfam06387
Location:1 → 169

Calcyon; D1 dopamine receptor-interacting protein (calcyon)
XM_036156412.1 → XP_036012305.1 neuronal vesicle trafficking-associated protein 2 isoform X2

UniProtKB/TrEMBL

Q5SS03

Conserved Domains (1) summary

pfam06387
Location:1 → 74

Calcyon; D1 dopamine receptor-interacting protein (calcyon)