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    Stag2 STAG2 cohesin complex component [ Mus musculus (house mouse) ]

    Gene ID: 20843, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Stag2provided by MGI
    Official Full Name
    STAG2 cohesin complex componentprovided by MGI
    Primary source
    MGI:MGI:1098583
    See related
    Ensembl:ENSMUSG00000025862 AllianceGenome:MGI:1098583
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SA-2; SAP2; 9230105L23Rik; B230112I07Rik
    Summary
    Enables chromatin binding activity. Acts upstream of or within stem cell population maintenance. Located in chromatin. Is expressed in several structures, including genitourinary system; integumental system; limb; liver; and nervous system. Human ortholog(s) of this gene implicated in Holoprosencephaly 13, X-linked and Mullegama-Klein-Martinez syndrome. Orthologous to human STAG2 (STAG2 cohesin complex component). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.4), liver E14 (RPKM 10.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stag2 in Genome Data Viewer
    Location:
    X A4; X 23.19 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (41238172..41366063)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (42149297..42277186)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47060 Neighboring gene X-linked inhibitor of apoptosis Neighboring gene STARR-positive B cell enhancer ABC_E9459 Neighboring gene zinc finger protein 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47063 Neighboring gene RIKEN cDNA B230118I11 gene Neighboring gene predicted gene, 54068 Neighboring gene STARR-seq mESC enhancer starr_47064

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. STAG2 promotes the myelination transcriptional program in oligodendrocytes. Cheng N, et al. Elife, 2022 Aug 12. PMID 35959892, Free PMC Article
    2. [Molecular pathogenesis of myelodysplastic syndromes with concurrent mutations in cohesin STAG2 and transcription factor RUNX1]. Ochi Y. Rinsho Ketsueki, 2021. PMID 34108313
    3. STAG2 inactivation reprograms glutamine metabolism of BRAF-mutant thyroid cancer cells. Li X, et al. Cell Death Dis, 2023 Jul 21. PMID 37479689, Free PMC Article
    4. Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells. Arruda NL, et al. Epigenetics Chromatin, 2020 Aug 10. PMID 32778134, Free PMC Article
    5. Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes. Ochi Y, et al. Cancer Discov, 2020 Jun. PMID 32249213, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STAG2 inactivation reprograms glutamine metabolism of BRAF-mutant thyroid cancer cells.
      Title: STAG2 inactivation reprograms glutamine metabolism of BRAF-mutant thyroid cancer cells.
    2. STAG2 promotes the myelination transcriptional program in oligodendrocytes.
      Title: STAG2 promotes the myelination transcriptional program in oligodendrocytes.
    3. [Molecular pathogenesis of myelodysplastic syndromes with concurrent mutations in cohesin STAG2 and transcription factor RUNX1].
      Title: [Molecular pathogenesis of myelodysplastic syndromes with concurrent mutations in cohesin STAG2 and transcription factor RUNX1].
    4. Essential Roles of Cohesin STAG2 in Mouse Embryonic Development and Adult Tissue Homeostasis.
      Title: Essential Roles of Cohesin STAG2 in Mouse Embryonic Development and Adult Tissue Homeostasis.
    5. Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells.
      Title: Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells.
    6. we show that loss of Stag2 cooperates with EWS-FLI1 and p53 mutation to promote sarcomagenesis in murine MSCs
      Title: Loss of Stag2 cooperates with EWS-FLI1 to transform murine Mesenchymal stem cells.
    7. a cohesin complex containing Rad21 and STAG2 cooperates with a STAG3-specific complex to maintain sister chromatid cohesion during the diplotene stage of meiosis
      Title: STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sister chromatid cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cohesin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cohesin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitotic cohesin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cohesin subunit SA-2
    Names
    SCC3 homolog 2
    nuclear protein SA2
    stromal antigen 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077712.2 → NP_001071180.1  cohesin subunit SA-2 isoform 1

      See identical proteins and their annotated locations for NP_001071180.1

      Status: VALIDATED

      Source sequence(s)
      AA461826, AK161072, AL672089, BC066041, CN669441, CO434048
      Consensus CDS
      CCDS40952.1
      UniProtKB/Swiss-Prot
      A2AFF5, O35638, Q6NZN7
      Related
      ENSMUSP00000110724.2, ENSMUST00000115072.8
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    2. NM_001290713.2 → NP_001277642.1  cohesin subunit SA-2 isoform 2

      See identical proteins and their annotated locations for NP_001277642.1

      Status: VALIDATED

      Source sequence(s)
      AA461826, AK161072, AL672089, BC066041, CN708963, CO434048
      Consensus CDS
      CCDS72371.1
      UniProtKB/TrEMBL
      A2AFF6
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    3. NM_001358225.1 → NP_001345154.1  cohesin subunit SA-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AA461826, AL672089
      Consensus CDS
      CCDS40952.1
      UniProtKB/Swiss-Prot
      A2AFF5, O35638, Q6NZN7
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    4. NM_021465.4 → NP_067440.3  cohesin subunit SA-2 isoform 1

      See identical proteins and their annotated locations for NP_067440.3

      Status: VALIDATED

      Source sequence(s)
      AA461826, AK146718, AK161072, BC066041, CO434048
      Consensus CDS
      CCDS40952.1
      UniProtKB/Swiss-Prot
      A2AFF5, O35638, Q6NZN7
      Related
      ENSMUSP00000063250.8, ENSMUST00000069619.14
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      41238172..41366063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251277.2 → XP_030107137.1  cohesin subunit SA-2 isoform X1

      UniProtKB/TrEMBL
      A2AFF6
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    2. XM_011250984.4 → XP_011249286.1  cohesin subunit SA-2 isoform X1

      See identical proteins and their annotated locations for XP_011249286.1

      UniProtKB/TrEMBL
      A2AFF6
      Related
      ENSMUSP00000110725.3, ENSMUST00000115073.9
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    3. XM_036161875.1 → XP_036017768.1  cohesin subunit SA-2 isoform X2

      UniProtKB/Swiss-Prot
      A2AFF5, O35638, Q6NZN7
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    4. XM_011250987.2 → XP_011249289.1  cohesin subunit SA-2 isoform X1

      See identical proteins and their annotated locations for XP_011249289.1

      UniProtKB/TrEMBL
      A2AFF6
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    5. XM_036161873.1 → XP_036017766.1  cohesin subunit SA-2 isoform X2

      UniProtKB/Swiss-Prot
      A2AFF5, O35638, Q6NZN7
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    6. XM_030251276.2 → XP_030107136.1  cohesin subunit SA-2 isoform X1

      UniProtKB/TrEMBL
      A2AFF6
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    7. XM_036161872.1 → XP_036017765.1  cohesin subunit SA-2 isoform X1

      UniProtKB/TrEMBL
      A2AFF6
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    8. XM_036161878.1 → XP_036017771.1  cohesin subunit SA-2 isoform X2

      UniProtKB/Swiss-Prot
      A2AFF5, O35638, Q6NZN7
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    9. XM_011250989.4 → XP_011249291.1  cohesin subunit SA-2 isoform X2

      See identical proteins and their annotated locations for XP_011249291.1

      UniProtKB/Swiss-Prot
      A2AFF5, O35638, Q6NZN7
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    10. XM_036161876.1 → XP_036017769.1  cohesin subunit SA-2 isoform X2

      UniProtKB/Swiss-Prot
      A2AFF5, O35638, Q6NZN7
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    11. XM_011250985.4 → XP_011249287.1  cohesin subunit SA-2 isoform X1

      See identical proteins and their annotated locations for XP_011249287.1

      UniProtKB/TrEMBL
      A2AFF6
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    12. XM_036161874.1 → XP_036017767.1  cohesin subunit SA-2 isoform X2

      UniProtKB/Swiss-Prot
      A2AFF5, O35638, Q6NZN7
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    13. XM_011250988.3 → XP_011249290.1  cohesin subunit SA-2 isoform X1

      See identical proteins and their annotated locations for XP_011249290.1

      UniProtKB/TrEMBL
      A2AFF6
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    14. XM_036161877.1 → XP_036017770.1  cohesin subunit SA-2 isoform X2

      UniProtKB/Swiss-Prot
      A2AFF5, O35638, Q6NZN7
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35638.3 GenPept UniProtKB/Swiss-Prot:O35638

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