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    Bst1 bone marrow stromal cell antigen 1 [ Mus musculus (house mouse) ]

    Gene ID: 12182, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bst1provided by MGI
    Official Full Name
    bone marrow stromal cell antigen 1provided by MGI
    Primary source
    MGI:MGI:105370
    See related
    Ensembl:ENSMUSG00000029082 AllianceGenome:MGI:105370
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bp3; BP-3; Ly65; Bsta1; CD157; 114/A10; A530073F09
    Summary
    Predicted to enable NAD+ nucleotidase, cyclic ADP-ribose generating and phosphorus-oxygen lyase activity. Predicted to be involved in several processes, including positive regulation of B cell proliferation; regulation of neutrophil chemotaxis; and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in uropod. Predicted to be active in plasma membrane. Is expressed in cerebellum; forebrain; and spleen white pulp. Orthologous to human BST1 (bone marrow stromal cell antigen 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in small intestine adult (RPKM 27.4), duodenum adult (RPKM 25.5) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Bst1 in Genome Data Viewer
    Location:
    5 B3; 5 23.84 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (43976235..44000810)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (43818880..43843468)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene predicted gene, 35762 Neighboring gene F-box and leucine-rich repeat protein 5 Neighboring gene STARR-seq mESC enhancer starr_12974 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:44215949-44216168 Neighboring gene STARR-positive B cell enhancer ABC_E8052 Neighboring gene STARR-seq mESC enhancer starr_12977 Neighboring gene STARR-seq mESC enhancer starr_12978 Neighboring gene STARR-seq mESC enhancer starr_12980 Neighboring gene predicted gene, 54296 Neighboring gene CD38 antigen Neighboring gene predicted gene 16015

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+ nucleotidase, cyclic ADP-ribose generating ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphorus-oxygen lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in uropod ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
    Names
    ADP-ribosyl cyclase 2
    BP-3 alloantigen
    BST-1
    antigen BP3
    bone marrow stromal antigen 1
    cADPr hydrolase 2
    cyclic ADP-ribose hydrolase 2
    leukocyte antigen 65
    ly-65
    NP_033893.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009763.3NP_033893.2  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor

      See identical proteins and their annotated locations for NP_033893.2

      Status: VALIDATED

      Source sequence(s)
      AC140277
      Consensus CDS
      CCDS19264.1
      UniProtKB/Swiss-Prot
      Q64277, Q8BRY3
      UniProtKB/TrEMBL
      A0A0R4J190
      Related
      ENSMUSP00000098796.5, ENSMUST00000101237.8
      Conserved Domains (1) summary
      pfam02267
      Location:35261
      Rib_hydrolayse; ADP-ribosyl cyclase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      43976235..44000810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)