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    Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha [ Mus musculus (house mouse) ]

    Gene ID: 19017, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ppargc1aprovided by MGI
    Official Full Name
    peroxisome proliferative activated receptor, gamma, coactivator 1 alphaprovided by MGI
    Primary source
    MGI:MGI:1342774
    See related
    Ensembl:ENSMUSG00000029167 AllianceGenome:MGI:1342774
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pgc1; PGC-1; Pgco1; Gm11133; Ppargc1; Pgc-1alpha; A830037N07Rik; PPARGC-1-alpha
    Summary
    This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in heart adult (RPKM 4.1), frontal lobe adult (RPKM 3.9) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ppargc1a in Genome Data Viewer
    Location:
    5 C1; 5 27.02 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (51611591..52273316, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (51454249..52115853, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13045 Neighboring gene adaptor protein complex AP-2, alpha 2 subunit pseudogene Neighboring gene STARR-seq mESC enhancer starr_13047 Neighboring gene STARR-seq mESC enhancer starr_13049 Neighboring gene predicted gene, 29924 Neighboring gene STARR-seq mESC enhancer starr_13050 Neighboring gene STARR-seq mESC enhancer starr_13051 Neighboring gene predicted gene 42614 Neighboring gene STARR-seq mESC enhancer starr_13052 Neighboring gene STARR-seq mESC enhancer starr_13053 Neighboring gene STARR-seq mESC enhancer starr_13054 Neighboring gene STARR-seq mESC enhancer starr_13055 Neighboring gene STARR-seq mESC enhancer starr_13057 Neighboring gene predicted gene, 40302 Neighboring gene microRNA 6417 Neighboring gene DEAH-box helicase 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lncRNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear receptor coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peroxisome proliferator activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables transcription coregulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to follicle-stimulating hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to thyroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in circadian regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in energy homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mitochondrion organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of podocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of progesterone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within respiratory electron transport chain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to dietary excess IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to muscle activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to muscle activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peroxisome proliferator-activated receptor gamma coactivator 1-alpha
    Names
    PPAR-gamma coactivator 1-alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402987.1NP_001389916.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform b

      Status: REVIEWED

      Source sequence(s)
      AC111037, AC116763
    2. NM_001402988.1NP_001389917.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform c

      Status: REVIEWED

      Source sequence(s)
      AC111037, AC116763, AC158149
      UniProtKB/TrEMBL
      A0A0G2JGG3
    3. NM_001402989.1NP_001389918.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform d

      Status: REVIEWED

      Source sequence(s)
      AC116763
      UniProtKB/TrEMBL
      A0A0G2JGG3
    4. NM_001402990.1NP_001389919.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform e

      Status: REVIEWED

      Source sequence(s)
      AC116763, AC163408
    5. NM_001402991.1NP_001389920.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform e

      Status: REVIEWED

      Source sequence(s)
      AC116763
    6. NM_008904.3NP_032930.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform a

      See identical proteins and their annotated locations for NP_032930.1

      Status: REVIEWED

      Source sequence(s)
      AC116763
      Consensus CDS
      CCDS19282.1
      UniProtKB/Swiss-Prot
      L0AM20, L0AN96, L0APB0, O70343, Q3UP72
      UniProtKB/TrEMBL
      A0A0G2JGG3
      Related
      ENSMUSP00000117040.2, ENSMUST00000132734.8
      Conserved Domains (1) summary
      cd12623
      Location:674764
      RRM_PPARGC1A; RNA recognition motif (RRM) found in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins

    RNA

    1. NR_027710.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC116763
    2. NR_132764.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC116763, BB853729, JX866948
    3. NR_175325.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC111037, AC116763, AC158149
    4. NR_175326.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC116763
    5. NR_175327.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC116763

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      51611591..52273316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503775.2XP_006503838.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X2

      UniProtKB/TrEMBL
      A0A0G2JGG3
      Conserved Domains (1) summary
      cd12623
      Location:670760
      RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    2. XM_036164894.1XP_036020787.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X6

      Conserved Domains (1) summary
      cd12623
      Location:674764
      RRM_PPARGC1A; RNA recognition motif (RRM) found in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    3. XM_017320718.3XP_017176207.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X5

      Conserved Domains (1) summary
      cd12623
      Location:549639
      RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    4. XM_030254205.2XP_030110065.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X5

      Conserved Domains (1) summary
      cd12623
      Location:549639
      RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins