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    NR1H3 nuclear receptor subfamily 1 group H member 3 [ Homo sapiens (human) ]

    Gene ID: 10062, updated on 3-Dec-2024

    Summary

    Official Symbol
    NR1H3provided by HGNC
    Official Full Name
    nuclear receptor subfamily 1 group H member 3provided by HGNC
    Primary source
    HGNC:HGNC:7966
    See related
    Ensembl:ENSG00000025434 MIM:602423; AllianceGenome:HGNC:7966
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LXRA; LXR-a; RLD-1
    Summary
    The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Ubiquitous expression in fat (RPKM 25.1), spleen (RPKM 16.7) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NR1H3 in Genome Data Viewer
    Location:
    11p11.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (47248300..47269033)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (47405058..47425803)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (47269851..47290584)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S20 pseudogene 26 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:47231264-47231443 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:47235129-47235965 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:47236089-47237288 Neighboring gene damage specific DNA binding protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4694 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:47270641-47270808 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:47280987-47281555 Neighboring gene Sharpr-MPRA regulatory region 2100 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4695 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3325 Neighboring gene Sharpr-MPRA regulatory region 9889 Neighboring gene MADD antisense RNA 1 Neighboring gene MAP kinase activating death domain Neighboring gene myosin binding protein C3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:47371915-47372896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:47372897-47373877

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
    EBI GWAS Catalog
    Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    matrix gag HIV-1 MA activates NR1H3 signaling in primary hepatocytes PubMed
    gag HIV-1 MA upregulates NR1H3 mRNA expression in HepG2 cells and primary hepatocytes PubMed
    gag HIV-1 MA upregulates NR1H3 (LXR-alpha) gene expresssion in HepG2 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cholesterol homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hormone-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hormone-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cholesterol storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of lipid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of macrophage activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of macrophage derived foam cell differentiation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in negative regulation of pancreatic juice secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of pinocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of secretion of lysosomal enzymes ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of type II interferon-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in phosphatidylcholine acyl-chain remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cholesterol efflux TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cholesterol transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of lipoprotein lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of circadian rhythm TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to progesterone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in triglyceride homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex EXP
    Inferred from Experiment
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    oxysterols receptor LXR-alpha
    NP_001123573.1
    NP_001123574.1
    NP_001238863.1
    NP_001238864.1
    NP_001350524.1
    NP_005684.2
    XP_005252763.1
    XP_011518107.1
    XP_011518108.1
    XP_011518109.1
    XP_011518110.1
    XP_016872545.1
    XP_024304066.1
    XP_047282149.1
    XP_047282150.1
    XP_047282151.1
    XP_047282153.1
    XP_047282154.1
    XP_047282155.1
    XP_047282156.1
    XP_047282157.1
    XP_047282158.1
    XP_054223344.1
    XP_054223345.1
    XP_054223346.1
    XP_054223347.1
    XP_054223348.1
    XP_054223349.1
    XP_054223350.1
    XP_054223351.1
    XP_054223352.1
    XP_054223353.1
    XP_054223354.1
    XP_054223355.1
    XP_054223356.1
    XP_054223357.1
    XP_054223358.1
    XP_054223359.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030392.1 RefSeqGene

      Range
      14697..25734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130101.3NP_001123573.1  oxysterols receptor LXR-alpha isoform 2

      See identical proteins and their annotated locations for NP_001123573.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AA644385, AI097478, AU133574, BC008819
      Consensus CDS
      CCDS44584.1
      UniProtKB/TrEMBL
      B2R8B9, B3KV37
      Related
      ENSP00000384745.3, ENST00000405853.7
      Conserved Domains (2) summary
      cd07160
      Location:78178
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
      cl11397
      Location:210385
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    2. NM_001130102.3NP_001123574.1  oxysterols receptor LXR-alpha isoform 3

      See identical proteins and their annotated locations for NP_001123574.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and lacks another exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (3) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA644385, AC018410, AI097478, AU135617, BC041172
      Consensus CDS
      CCDS44585.1
      UniProtKB/TrEMBL
      B2R8B9, B3KV37
      Related
      ENSP00000378793.3, ENST00000395397.7
      Conserved Domains (2) summary
      cd06954
      Location:165400
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:33133
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    3. NM_001251934.2NP_001238863.1  oxysterols receptor LXR-alpha isoform 4

      See identical proteins and their annotated locations for NP_001238863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains 2 alternate exons at the 5' end compared to variant 1. This results in translation initiation from an in-frame upstream AUG, and an isoform (4) with a longer and distinct N-terminus compared to isoform 1. Variants 4 and 5 (which differ in the 5'UTR) encode the same isoform.
      Source sequence(s)
      AA644385, AI097478, AK302132, AK311590
      Consensus CDS
      CCDS73285.1
      UniProtKB/TrEMBL
      B2R8B9, B3KV37, B4DXU5
      Related
      ENST00000529540.5
      Conserved Domains (2) summary
      cd06954
      Location:216451
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:84184
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    4. NM_001251935.2NP_001238864.1  oxysterols receptor LXR-alpha isoform 4

      See identical proteins and their annotated locations for NP_001238864.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains 2 alternate exons at the 5' end compared to variant 1. This results in translation initiation from an in-frame upstream AUG, and an isoform (4) with a longer and distinct N-terminus compared to isoform 1. Variants 4 and 5 (which differ in the 5'UTR) encode the same isoform (4).
      Source sequence(s)
      AA644385, AI097478, AK302132, AK311590
      Consensus CDS
      CCDS73285.1
      UniProtKB/TrEMBL
      B2R8B9, B3KV37, B4DXU5
      Related
      ENSP00000477707.1, ENST00000616973.4
      Conserved Domains (2) summary
      cd06954
      Location:216451
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:84184
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    5. NM_001363595.2NP_001350524.1  oxysterols receptor LXR-alpha isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC018410
      Consensus CDS
      CCDS86200.1
      UniProtKB/TrEMBL
      B5MBY7, E9PID2
      Related
      ENSP00000385073.1, ENST00000405576.5
      Conserved Domains (2) summary
      cd07160
      Location:33133
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
      cl11397
      Location:165340
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    6. NM_005693.4NP_005684.2  oxysterols receptor LXR-alpha isoform 1

      See identical proteins and their annotated locations for NP_005684.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
      Source sequence(s)
      AA644385, AI097478, AK290614, AK302132
      Consensus CDS
      CCDS7929.1
      UniProtKB/Swiss-Prot
      A8K3J9, D3DQR1, Q13133, Q8IW13, Q96H87
      UniProtKB/TrEMBL
      B2R8B9, B3KV37, F1D8N1
      Related
      ENSP00000387946.2, ENST00000441012.7
      Conserved Domains (2) summary
      cd06954
      Location:210445
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:78178
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      47248300..47269033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426201.1XP_047282157.1  oxysterols receptor LXR-alpha isoform X1

      UniProtKB/TrEMBL
      B2R8B9, B3KV37
    2. XM_011519805.3XP_011518107.1  oxysterols receptor LXR-alpha isoform X2

      See identical proteins and their annotated locations for XP_011518107.1

      UniProtKB/Swiss-Prot
      A8K3J9, D3DQR1, Q13133, Q8IW13, Q96H87
      UniProtKB/TrEMBL
      B2R8B9, B3KV37, F1D8N1
      Conserved Domains (2) summary
      cd06954
      Location:210445
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:78178
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    3. XM_047426198.1XP_047282154.1  oxysterols receptor LXR-alpha isoform X1

      UniProtKB/TrEMBL
      B2R8B9, B3KV37
    4. XM_011519808.3XP_011518110.1  oxysterols receptor LXR-alpha isoform X8

      Conserved Domains (1) summary
      cd06954
      Location:1233
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    5. XM_024448298.2XP_024304066.1  oxysterols receptor LXR-alpha isoform X1

      UniProtKB/TrEMBL
      B2R8B9, B3KV37
      Conserved Domains (2) summary
      cd06954
      Location:165400
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:33133
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    6. XM_047426197.1XP_047282153.1  oxysterols receptor LXR-alpha isoform X1

      UniProtKB/TrEMBL
      B2R8B9, B3KV37
    7. XM_047426193.1XP_047282149.1  oxysterols receptor LXR-alpha isoform X1

      UniProtKB/TrEMBL
      B2R8B9, B3KV37
    8. XM_047426202.1XP_047282158.1  oxysterols receptor LXR-alpha isoform X7

    9. XM_047426194.1XP_047282150.1  oxysterols receptor LXR-alpha isoform X2

      UniProtKB/Swiss-Prot
      A8K3J9, D3DQR1, Q13133, Q8IW13, Q96H87
      UniProtKB/TrEMBL
      B2R8B9, B3KV37, F1D8N1
      Related
      ENSP00000420656.1, ENST00000467728.5
    10. XM_047426200.1XP_047282156.1  oxysterols receptor LXR-alpha isoform X6

      UniProtKB/TrEMBL
      B2R8B9, B3KV37
    11. XM_005252706.2XP_005252763.1  oxysterols receptor LXR-alpha isoform X2

      See identical proteins and their annotated locations for XP_005252763.1

      UniProtKB/Swiss-Prot
      A8K3J9, D3DQR1, Q13133, Q8IW13, Q96H87
      UniProtKB/TrEMBL
      B2R8B9, B3KV37, F1D8N1
      Conserved Domains (2) summary
      cd06954
      Location:210445
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cd07160
      Location:78178
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
    12. XM_047426195.1XP_047282151.1  oxysterols receptor LXR-alpha isoform X2

      UniProtKB/Swiss-Prot
      A8K3J9, D3DQR1, Q13133, Q8IW13, Q96H87
      UniProtKB/TrEMBL
      B2R8B9, B3KV37, F1D8N1
    13. XM_011519806.2XP_011518108.1  oxysterols receptor LXR-alpha isoform X3

      UniProtKB/TrEMBL
      B5MBY7, E9PID2
      Conserved Domains (2) summary
      cd07160
      Location:33133
      NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
      cl11397
      Location:165340
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    14. XM_011519807.2XP_011518109.1  oxysterols receptor LXR-alpha isoform X5

      See identical proteins and their annotated locations for XP_011518109.1

      Conserved Domains (1) summary
      cd06954
      Location:76311
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    15. XM_017017056.2XP_016872545.1  oxysterols receptor LXR-alpha isoform X4

    16. XM_047426199.1XP_047282155.1  oxysterols receptor LXR-alpha isoform X1

      UniProtKB/TrEMBL
      B2R8B9, B3KV37

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      47405058..47425803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367381.1XP_054223356.1  oxysterols receptor LXR-alpha isoform X1

      UniProtKB/TrEMBL
      B2R8B9, B3KV37
    2. XM_054367372.1XP_054223347.1  oxysterols receptor LXR-alpha isoform X2

      UniProtKB/Swiss-Prot
      A8K3J9, D3DQR1, Q13133, Q8IW13, Q96H87
      UniProtKB/TrEMBL
      B2R8B9, B3KV37, F1D8N1
    3. XM_054367376.1XP_054223351.1  oxysterols receptor LXR-alpha isoform X1

      UniProtKB/TrEMBL
      B2R8B9, B3KV37
    4. XM_054367384.1XP_054223359.1  oxysterols receptor LXR-alpha isoform X8

    5. XM_054367382.1XP_054223357.1  oxysterols receptor LXR-alpha isoform X1

      UniProtKB/TrEMBL
      B2R8B9, B3KV37
    6. XM_054367378.1XP_054223353.1  oxysterols receptor LXR-alpha isoform X1

      UniProtKB/TrEMBL
      B2R8B9, B3KV37
    7. XM_054367375.1XP_054223350.1  oxysterols receptor LXR-alpha isoform X1

      UniProtKB/TrEMBL
      B2R8B9, B3KV37
    8. XM_054367369.1XP_054223344.1  oxysterols receptor LXR-alpha isoform X1

      UniProtKB/TrEMBL
      B2R8B9, B3KV37
    9. XM_054367383.1XP_054223358.1  oxysterols receptor LXR-alpha isoform X7

    10. XM_054367370.1XP_054223345.1  oxysterols receptor LXR-alpha isoform X2

      UniProtKB/Swiss-Prot
      A8K3J9, D3DQR1, Q13133, Q8IW13, Q96H87
      UniProtKB/TrEMBL
      B2R8B9, B3KV37, F1D8N1
    11. XM_054367380.1XP_054223355.1  oxysterols receptor LXR-alpha isoform X6

      UniProtKB/TrEMBL
      B2R8B9, B3KV37
    12. XM_054367371.1XP_054223346.1  oxysterols receptor LXR-alpha isoform X2

      UniProtKB/Swiss-Prot
      A8K3J9, D3DQR1, Q13133, Q8IW13, Q96H87
      UniProtKB/TrEMBL
      B2R8B9, B3KV37, F1D8N1
    13. XM_054367373.1XP_054223348.1  oxysterols receptor LXR-alpha isoform X3

      UniProtKB/TrEMBL
      B5MBY7, E9PID2
    14. XM_054367379.1XP_054223354.1  oxysterols receptor LXR-alpha isoform X5

    15. XM_054367374.1XP_054223349.1  oxysterols receptor LXR-alpha isoform X4

    16. XM_054367377.1XP_054223352.1  oxysterols receptor LXR-alpha isoform X1

      UniProtKB/TrEMBL
      B2R8B9, B3KV37