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    CCL7 C-C motif chemokine ligand 7 [ Homo sapiens (human) ]

    Gene ID: 6354, updated on 9-Dec-2024

    Summary

    Official Symbol
    CCL7provided by HGNC
    Official Full Name
    C-C motif chemokine ligand 7provided by HGNC
    Primary source
    HGNC:HGNC:10634
    See related
    Ensembl:ENSG00000108688 MIM:158106; AllianceGenome:HGNC:10634
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7
    Summary
    This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in bone marrow (RPKM 6.7) and appendix (RPKM 1.6) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CCL7 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (34270221..34272242)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (35216497..35218518)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (32597240..32599261)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8431 Neighboring gene long intergenic non-protein coding RNA 1989 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:32505165-32505693 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:32510298-32510505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:32531127-32531628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:32531629-32532128 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:32578883-32580082 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:32581026-32582000 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:32582001-32582975 Neighboring gene C-C motif chemokine ligand 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:32624651-32625240 Neighboring gene C-C motif chemokine ligand 11 Neighboring gene C-C motif chemokine ligand 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Chemokines such as MCP-3 and MCP-2 that can compete with high affinity for MIP-1beta binding to CCR5 can also compete for monomeric HIV-1 gp120 binding to CCR5, although with variable potencies PubMed
    Tat tat HIV-1 and the viral protein Tat modulate the expression of chemokine (C-C motif) ligand 7 (CCL7; MCP-3) in immature dendritic cells and monocyte-derived macrophages PubMed
    tat HIV-1 Tat upregulates expression of MCP-3 in immature dendritic cells, suggesting Tat reprograms host dendritic cell gene expression to facilitate expansion of HIV-1 infection PubMed
    tat HIV-1 Tat is a competitive inhibitor of MCP-3 binding to CCR3 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC138463, MGC138465

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables CCR1 chemokine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables CCR2 chemokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in eosinophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in eosinophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular calcium ion homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in monocyte chemotaxis IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of natural killer cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    C-C motif chemokine 7
    Names
    chemokine (C-C motif) ligand 7
    monocyte chemoattractant protein 3
    monocyte chemotactic protein 3
    small inducible cytokine A7 (monocyte chemotactic protein 3)
    small-inducible cytokine A7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006273.4NP_006264.2  C-C motif chemokine 7 precursor

      See identical proteins and their annotated locations for NP_006264.2

      Status: REVIEWED

      Source sequence(s)
      AC005549, X71087
      Consensus CDS
      CCDS11278.1
      UniProtKB/Swiss-Prot
      P80098, Q569J6
      Related
      ENSP00000367832.2, ENST00000378569.2
      Conserved Domains (1) summary
      pfam00048
      Location:3289
      IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      34270221..34272242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      35216497..35218518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)