U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ADRA1D adrenoceptor alpha 1D [ Homo sapiens (human) ]

    Gene ID: 146, updated on 9-Dec-2024

    Summary

    Official Symbol
    ADRA1Dprovided by HGNC
    Official Full Name
    adrenoceptor alpha 1Dprovided by HGNC
    Primary source
    HGNC:HGNC:280
    See related
    Ensembl:ENSG00000171873 MIM:104219; AllianceGenome:HGNC:280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DAR; ADRA1; ADRA1A; ADRA1R; ALPHA1; dJ779E11.2
    Summary
    Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 2.3), spleen (RPKM 0.8) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADRA1D in Genome Data Viewer
    Location:
    20p13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (4220630..4249287, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (4254950..4283627, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (4201277..4229934, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904861 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:4141411-4142344 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:4148169-4148870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12639 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12641 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:4175883-4176064 Neighboring gene spermine oxidase Neighboring gene MPRA-validated peak4129 silencer Neighboring gene long intergenic non-protein coding RNA 1433 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:4197441-4198178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17493 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:4202467-4202967 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:4212957-4213457 Neighboring gene Sharpr-MPRA regulatory region 5115 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:4244845-4245360 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:4306716-4307915 Neighboring gene uncharacterized LOC124904862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:4501639-4502140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:4502141-4502640 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:4526897-4527638 Neighboring gene uncharacterized LOC105372510

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha1-adrenergic receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    alpha-1D adrenergic receptor
    Names
    adrenergic, alpha -1D-, receptor
    adrenergic, alpha-1A-, receptor
    alpha-1A adrenergic receptor
    alpha-1D adrenoceptor
    alpha-1D adrenoreceptor
    alpha-adrenergic receptor 1a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000678.4NP_000669.1  alpha-1D adrenergic receptor

      See identical proteins and their annotated locations for NP_000669.1

      Status: REVIEWED

      Source sequence(s)
      AL121675, AL357040, S70782, U03864
      Consensus CDS
      CCDS13079.1
      UniProtKB/Swiss-Prot
      P25100, Q9NPY0
      UniProtKB/TrEMBL
      B0ZBE0
      Related
      ENSP00000368766.4, ENST00000379453.6
      Conserved Domains (1) summary
      cd15327
      Location:97413
      7tmA_alpha1D_AR; alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      4220630..4249287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      4254950..4283627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)