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    BRD3 bromodomain containing 3 [ Homo sapiens (human) ]

    Gene ID: 8019, updated on 27-Nov-2024

    Summary

    Official Symbol
    BRD3provided by HGNC
    Official Full Name
    bromodomain containing 3provided by HGNC
    Primary source
    HGNC:HGNC:1104
    See related
    Ensembl:ENSG00000169925 MIM:601541; AllianceGenome:HGNC:1104
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ORFX; FSHRG2; RING3L
    Summary
    This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 8.0), brain (RPKM 7.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BRD3 in Genome Data Viewer
    Location:
    9q34.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (134030305..134068548, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (146246241..146284500, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (136895427..136933148, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene SARDH intron CAGE-defined T cell enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136550530-136551030 Neighboring gene sarcosine dehydrogenase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136576505-136577208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136580725-136581428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136581429-136582130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136592563-136593073 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:136608197-136608347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29248 Neighboring gene Sharpr-MPRA regulatory region 10163 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:136640028-136640254 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136644953-136645920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29249 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136652072-136652624 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29250 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136666341-136666861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136667983-136668505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136668506-136669028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136676904-136677659 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136677660-136678414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136679171-136679924 Neighboring gene vav guanine nucleotide exchange factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29253 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136689618-136690614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136690615-136691612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136699176-136699998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136704646-136705596 Neighboring gene Sharpr-MPRA regulatory region 14277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29254 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136714035-136715017 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136715018-136715999 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136717779-136718308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136719038-136719538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136719539-136720039 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136722620-136723471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136726902-136727725 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136727726-136728548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136732543-136733366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136737072-136737572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136737573-136738073 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:136739070-136740269 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136741055-136741790 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136741791-136742524 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136747665-136748398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136749133-136749866 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:136753100-136754299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136779963-136780912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136780913-136781861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136784581-136785360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136795832-136796480 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136809459-136810312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29257 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136813513-136814022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136814023-136814532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136815043-136815553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29259 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136822320-136822896 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136822897-136823473 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136823474-136824051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136824052-136824628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136825207-136825782 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136825783-136826360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29263 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136835167-136836051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136836052-136836935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29265 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136843801-136844318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136844835-136845350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136848313-136849057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136853577-136854304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136854305-136855032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136855033-136855760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136856489-136857216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136855761-136856488 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20469 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136857945-136858672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20473 Neighboring gene uncharacterized LOC100130548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136924735-136925476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136927711-136928622 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20474 Neighboring gene BRD3 opposite strand Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:136956997-136957776 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:136957777-136958556 Neighboring gene MPRA-validated peak7340 silencer Neighboring gene ARF GTPase 4 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136991223-136992104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136992105-136992986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136994027-136994872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136994873-136995716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136997435-136998004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20476 Neighboring gene WDR5 divergent transcript Neighboring gene WD repeat domain 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ23227, FLJ41328, KIAA0043

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lncRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lysine-acetylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molecular condensate scaffold activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    bromodomain-containing protein 3
    Names
    RING3-like protein
    female sterile homeotic related gene 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007371.4NP_031397.1  bromodomain-containing protein 3

      See identical proteins and their annotated locations for NP_031397.1

      Status: REVIEWED

      Source sequence(s)
      AA766480, AK026880, AK123322, AL591386, BC010699, BI545861, D26362, DW413353
      Consensus CDS
      CCDS6980.1
      UniProtKB/Swiss-Prot
      B1APD9, Q15059, Q4G5Y3, Q5T1R7, Q8N5M3, Q92645
      Related
      ENSP00000305918.6, ENST00000303407.12
      Conserved Domains (3) summary
      cd05497
      Location:34140
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:311412
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:571635
      BET; Bromodomain extra-terminal - transcription regulation

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      134030305..134068548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423906.1XP_047279862.1  bromodomain-containing protein 3 isoform X2

    2. XM_047423903.1XP_047279859.1  bromodomain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      B1APD9, Q15059, Q4G5Y3, Q5T1R7, Q8N5M3, Q92645
    3. XM_047423905.1XP_047279861.1  bromodomain-containing protein 3 isoform X2

    4. XM_006717291.4XP_006717354.1  bromodomain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006717354.1

      UniProtKB/Swiss-Prot
      B1APD9, Q15059, Q4G5Y3, Q5T1R7, Q8N5M3, Q92645
      Conserved Domains (3) summary
      cd05497
      Location:34140
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:311412
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:571635
      BET; Bromodomain extra-terminal - transcription regulation
    5. XM_017015165.3XP_016870654.1  bromodomain-containing protein 3 isoform X2

      Conserved Domains (3) summary
      cd05497
      Location:34140
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:311412
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:571635
      BET; Bromodomain extra-terminal - transcription regulation
    6. XM_047423904.1XP_047279860.1  bromodomain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      B1APD9, Q15059, Q4G5Y3, Q5T1R7, Q8N5M3, Q92645
    7. XM_011519052.3XP_011517354.1  bromodomain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011517354.1

      UniProtKB/Swiss-Prot
      B1APD9, Q15059, Q4G5Y3, Q5T1R7, Q8N5M3, Q92645
      Conserved Domains (3) summary
      cd05497
      Location:34140
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:311412
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:571635
      BET; Bromodomain extra-terminal - transcription regulation

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      146246241..146284500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363877.1XP_054219852.1  bromodomain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      B1APD9, Q15059, Q4G5Y3, Q5T1R7, Q8N5M3, Q92645
    2. XM_054363876.1XP_054219851.1  bromodomain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      B1APD9, Q15059, Q4G5Y3, Q5T1R7, Q8N5M3, Q92645
    3. XM_054363880.1XP_054219855.1  bromodomain-containing protein 3 isoform X2

    4. XM_054363879.1XP_054219854.1  bromodomain-containing protein 3 isoform X2

    5. XM_054363878.1XP_054219853.1  bromodomain-containing protein 3 isoform X2

    6. XM_054363874.1XP_054219849.1  bromodomain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      B1APD9, Q15059, Q4G5Y3, Q5T1R7, Q8N5M3, Q92645
    7. XM_054363875.1XP_054219850.1  bromodomain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      B1APD9, Q15059, Q4G5Y3, Q5T1R7, Q8N5M3, Q92645