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    Rnf181 ring finger protein 181 [ Mus musculus (house mouse) ]

    Gene ID: 66510, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf181provided by MGI
    Official Full Name
    ring finger protein 181provided by MGI
    Primary source
    MGI:MGI:1913760
    See related
    Ensembl:ENSMUSG00000055850 AllianceGenome:MGI:1913760
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700047F16Rik; 2500002L14Rik; 6230415N01Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein autoubiquitination. Predicted to be active in cytoplasm. Is expressed in several structures, including adrenal gland; central nervous system; liver lobe; olfactory epithelium; and thymus primordium. Orthologous to human RNF181 (ring finger protein 181). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 73.1), adrenal adult (RPKM 55.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf181 in Genome Data Viewer
    Location:
    6 C1; 6 32.27 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72336695..72343977, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72359712..72366994, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 39 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:72295216-72295399 Neighboring gene RIKEN cDNA 0610030E20 gene Neighboring gene transmembrane protein 150A Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:72312603-72312712 Neighboring gene vesicle-associated membrane protein 5 Neighboring gene predicted gene, 52494 Neighboring gene vesicle-associated membrane protein 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RN181 regulates the biological behaviors of oral squamous cell carcinoma cells via mediating ERK/MAPK signaling pathway. Li Y, et al. Acta Histochem, 2021 Jul. PMID 34052676
    2. Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction. Yang W, et al. Cell Chem Biol, 2023 Oct 19. PMID 37442135
    3. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    5. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RN181 regulates the biological behaviors of oral squamous cell carcinoma cells via mediating ERK/MAPK signaling pathway.
      Title: RN181 regulates the biological behaviors of oral squamous cell carcinoma cells via mediating ERK/MAPK signaling pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103058

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF181
    Names
    RING-type E3 ubiquitin transferase RNF181
    NP_001318096.1
    NP_001318097.1
    NP_001318098.1
    NP_001318099.1
    NP_001318100.1
    NP_001318101.1
    NP_001318102.1
    NP_079883.3
    XP_030111400.1
    XP_030111401.1
    XP_030111402.1
    XP_030111403.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331167.1 → NP_001318096.1  E3 ubiquitin-protein ligase RNF181 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA154118, AC116115, AK018849, AK166904, BY086964
      Consensus CDS
      CCDS85064.1
      UniProtKB/Swiss-Prot
      Q9CY62
      Related
      ENSMUSP00000138327.2, ENSMUST00000154098.3
      Conserved Domains (1) summary
      cd16669
      Location:40 → 85
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

    2. NM_001331168.1 → NP_001318097.1  E3 ubiquitin-protein ligase RNF181 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AA154118, AK014094, BY772494
      Consensus CDS
      CCDS90058.1
      UniProtKB/Swiss-Prot
      Q9CY62
      Related
      ENSMUSP00000070370.7, ENSMUST00000069595.13

    3. NM_001331169.1 → NP_001318098.1  E3 ubiquitin-protein ligase RNF181 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA154118, AK166904, BY772494, CK387918
      Consensus CDS
      CCDS85064.1
      UniProtKB/Swiss-Prot
      Q9CY62
      Conserved Domains (1) summary
      cd16669
      Location:40 → 85
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

    4. NM_001331170.1 → NP_001318099.1  E3 ubiquitin-protein ligase RNF181 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116115

    5. NM_001331171.1 → NP_001318100.1  E3 ubiquitin-protein ligase RNF181 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116115
      Consensus CDS
      CCDS90057.1
      UniProtKB/TrEMBL
      D3YUJ1
      Related
      ENSMUSP00000109729.2, ENSMUST00000114095.2

    6. NM_001331172.1 → NP_001318101.1  E3 ubiquitin-protein ligase RNF181 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC116115

    7. NM_001331173.1 → NP_001318102.1  E3 ubiquitin-protein ligase RNF181 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC116115

    8. NM_025607.4 → NP_079883.3  E3 ubiquitin-protein ligase RNF181 isoform 1

      See identical proteins and their annotated locations for NP_079883.3

      Status: VALIDATED

      Source sequence(s)
      AA154118, AK166904, BY772494
      Consensus CDS
      CCDS20240.1
      UniProtKB/Swiss-Prot
      Q8CEU6, Q9CY62, Q9D2T4
      Related
      ENSMUSP00000066128.6, ENSMUST00000069580.12
      Conserved Domains (1) summary
      cd16669
      Location:87 → 132
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

    RNA

    1. NR_138579.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA154118, AC116115, AK166904, BB851224, BY772494

    2. NR_138580.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA154118, AK166904, BY772494, DV652726

    3. NR_138581.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116115
      Related
      ENSMUST00000125554.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      72336695..72343977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255540.1 → XP_030111400.1  E3 ubiquitin-protein ligase RNF181 isoform X1

      UniProtKB/Swiss-Prot
      Q8CEU6, Q9CY62, Q9D2T4
      Conserved Domains (1) summary
      cd16669
      Location:87 → 132
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

    2. XM_030255542.1 → XP_030111402.1  E3 ubiquitin-protein ligase RNF181 isoform X2

      Conserved Domains (1) summary
      cd16669
      Location:40 → 85
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

    3. XM_030255541.2 → XP_030111401.1  E3 ubiquitin-protein ligase RNF181 isoform X1

      UniProtKB/Swiss-Prot
      Q8CEU6, Q9CY62, Q9D2T4
      Conserved Domains (1) summary
      cd16669
      Location:87 → 132
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

    4. XM_030255543.1 → XP_030111403.1  E3 ubiquitin-protein ligase RNF181 isoform X2

      Conserved Domains (1) summary
      cd16669
      Location:40 → 85
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CY62.1 GenPept UniProtKB/Swiss-Prot:Q9CY62

    Gene LinkOut

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