SCAR2 SCAR homolog 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: SCAR2
Official Full Name: SCAR homolog 2
Primary source: TAIR:AT2G38440
Locus tag: AT2G38440
See related: Araport:AT2G38440
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATSCAR2; DIS3; IRREGULAR TRICHOME BRANCH1; IRREGULAR TRICHOME BRANCH1; ITB1; SCAR homolog 2; SCAR HOMOLOG 2; T19C21.7; T19C21_7; WAVE4
Summary: Encodes a subunit of the WAVE complex. The WAVE complex is required for activation of ARP2/3 complex which functions in actin microfilament nucleation and branching. Mutations cause defects in both the actin and microtubule cytoskeletons that result in aberrant epidermal cell expansion. itb1 mutants showed irregularities in trichome branch positioning and expansion. The SHD domain of this protein binds to BRK1 and overexpression of the SHD domain results in a dominant negative phenotype.
NEW: Try the new Gene table
Try the new Transcript table

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

ITB1 Encodes a Plant Scar/WAVE homolog called SCAR2. Loss of function of ITB1/SCAR2 leads to actin and microtubule defects. [IRREGULAR TRICHOME BRANCH1] [ITB1]
Title: IRREGULAR TRICHOME BRANCH1 in Arabidopsis encodes a plant homolog of the actin-related protein2/3 complex activator Scar/WAVE that regulates actin and microtubule organization.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_129400.3

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within actin nucleation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of actin nucleation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of actin nucleation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within trichome branching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trichome morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trichome morphogenesis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of SCAR complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of SCAR complex	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info

NP_181378.2

SCAR homolog 2 (SCAR2); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: in 6 processes; LOCATED IN: SCAR complex, plasma membrane, cytoplasm; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Actin-binding WH2 (InterPro:IPR003124); BEST Arabidopsis thaliana protein match is: SCAR family protein 4 (TAIR:AT5G01730.1); Has 5162 Blast hits to 2275 proteins in 363 species: Archae - 24; Bacteria - 2785; Metazoa - 880; Fungi - 591; Plants - 224; Viruses - 0; Other Eukaryotes - 658 (source: NCBI BLink).