U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HXK2 hexokinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816505, updated on 18-Sep-2024

    Summary

    Official Symbol
    HXK2
    Official Full Name
    hexokinase 2
    Primary source
    TAIR:AT2G19860
    Locus tag
    AT2G19860
    See related
    Araport:AT2G19860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA HEXOKINASE 2; ATHXK2; F6F22.11; F6F22_11; hexokinase 2; HEXOKINASE 2
    Summary
    Encodes a protein with hexokinase activity (AtHXK2) and acts as a sensor for plant sugar responses.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HXK2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (8570607..8574067)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene transcription repressor Neighboring gene tRNA/rRNA methyltransferase (SpoU) family protein Neighboring gene Nucleotide-diphospho-sugar transferases superfamily protein

    Pathways from PubChem

    General gene information

    Markers

    NM_001084452.2
    NM_127544.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables D-glucose binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fructokinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glucokinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hexokinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hexokinase-dependent signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hexose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sugar mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
     
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
     
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    hexokinase 2
    NP_001077921.1
    • hexokinase 2 (HXK2); CONTAINS InterPro DOMAIN/s: Hexokinase, N-terminal (InterPro:IPR022672), Hexokinase, conserved site (InterPro:IPR019807), Hexokinase, C-terminal (InterPro:IPR022673), Hexokinase (InterPro:IPR001312); BEST Arabidopsis thaliana protein match is: hexokinase 1 (TAIR:AT4G29130.1); Has 2393 Blast hits to 2115 proteins in 319 species: Archae - 0; Bacteria - 88; Metazoa - 1275; Fungi - 598; Plants - 290; Viruses - 0; Other Eukaryotes - 142 (source: NCBI BLink).
    NP_179576.1
    • hexokinase 2 (HXK2); FUNCTIONS IN: fructokinase activity, hexokinase activity, glucokinase activity, ATP binding; INVOLVED IN: in 7 processes; LOCATED IN: mitochondrion, plastid; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Hexokinase, N-terminal (InterPro:IPR022672), Hexokinase, conserved site (InterPro:IPR019807), Hexokinase, C-terminal (InterPro:IPR022673), Hexokinase (InterPro:IPR001312); BEST Arabidopsis thaliana protein match is: hexokinase 1 (TAIR:AT4G29130.1); Has 2443 Blast hits to 2159 proteins in 323 species: Archae - 0; Bacteria - 89; Metazoa - 1303; Fungi - 623; Plants - 290; Viruses - 0; Other Eukaryotes - 138 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      8570607..8574067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127544.3NP_179576.1  hexokinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179576.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P93834, Q0WT93, Q84WJ5
      UniProtKB/TrEMBL
      A0A178VX81, A0A5S9WZF2, A0A654EUE1
      Conserved Domains (1) summary
      PLN02405
      Location:1497
      PLN02405; hexokinase
    2. NM_001084452.2NP_001077921.1  hexokinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077921.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8MRW9
      Conserved Domains (2) summary
      pfam00349
      Location:1131
      Hexokinase_1; Hexokinase
      pfam03727
      Location:137378
      Hexokinase_2; Hexokinase