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    CRF5 cytokinin response factor 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819239, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CRF5
    Official Full Name
    cytokinin response factor 5
    Primary source
    TAIR:AT2G46310
    Locus tag
    AT2G46310
    See related
    Araport:AT2G46310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cytokinin response factor 5; T3F17.4
    Summary
    CRF5 encodes one of the six cytokinin response factors. It is transcriptionally upregulated in response to cytokinin. CRF5 belongs to the AP2/ERF superfamily of the transcriptional factors. CRF proteins rapidly relocalize to the nucleus in response to cytokinin. Analysis of loos-of-function mutants revealed that the CRFs function redundantly to regulate the development of embryos, cotyledons and leaves.
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    Genomic context

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    See CRF5 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (19011462..19013018)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Mitochondrial substrate carrier family protein Neighboring gene arabinogalactan protein 16

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A subset of Arabidopsis AP2 transcription factors mediates cytokinin responses in concert with a two-component pathway. Rashotte AM, et al. Proc Natl Acad Sci U S A, 2006 Jul 18. PMID 16832061, Free PMC Article
    2. CRFs form protein-protein interactions with each other and with members of the cytokinin signalling pathway in Arabidopsis via the CRF domain. Cutcliffe JW, et al. J Exp Bot, 2011 Oct. PMID 21705390, Free PMC Article
    3. A PXY-Mediated Transcriptional Network Integrates Signaling Mechanisms to Control Vascular Development in Arabidopsis. Smit ME, et al. Plant Cell, 2020 Feb. PMID 31806676, Free PMC Article
    4. Transcriptional regulation of nitrogen-associated metabolism and growth. Gaudinier A, et al. Nature, 2018 Nov. PMID 30356219
    5. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Riechmann JL, et al. Science, 2000 Dec 15. PMID 11118137

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_130194.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cotyledon development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cytokinin response factor 5
    NP_182154.1
    • cytokinin response factor 5 (CRF5); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: cytokinin response factor 6 (TAIR:AT3G61630.1); Has 5622 Blast hits to 5574 proteins in 244 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 5609; Viruses - 2; Other Eukaryotes - 11 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      19011462..19013018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130194.5 → NP_182154.1  cytokinin response factor 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182154.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82339
      UniProtKB/TrEMBL
      A0A5S9X7G6, A0A654F2F6
      Conserved Domains (1) summary
      smart00380
      Location:98 → 154
      AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82339.1

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