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    PD1 prephenate dehydratase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817329, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PD1
    Official Full Name
    prephenate dehydratase 1
    Primary source
    TAIR:AT2G27820
    Locus tag
    AT2G27820
    See related
    Araport:AT2G27820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ADT3; arogenate dehydratase 3; F15K20.8; F15K20_8; prephenate dehydratase 1
    Summary
    Encodes a plastid-localized arogenate dehydratase involved in phenylalanine biosynthesis. Not less than six genes encoding ADT were identified in the Arabidopsis genome: ADT1 [At1g11790]; ADT2 [At3g07630]; ADT3 [At2g27820]; ADT4 [At3g44720]; ADT5 [At5g22630]; and ADT6 [At1g08250].
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    Genomic context

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    See PD1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (11856571..11858288)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene nucleobase-ascorbate transporter 12 Neighboring gene uncharacterized protein Neighboring gene histone deacetylase-related / HD-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Dehydratase ADT3 Affects ROS Homeostasis and Cotyledon Development. Para A, et al. Plant Physiol, 2016 Oct. PMID 27540109, Free PMC Article
    2. Plastid Deficient 1 Is Essential for the Accumulation of Plastid-Encoded RNA Polymerase Core Subunit β and Chloroplast Development in Arabidopsis. Yang Z, et al. Int J Mol Sci, 2021 Dec 20. PMID 34948448, Free PMC Article
    3. Reduced Arogenate Dehydratase Expression: Ramifications for Photosynthesis and Metabolism. Höhner R, et al. Plant Physiol, 2018 May. PMID 29523714, Free PMC Article
    4. G-protein-coupled receptor 1, G-protein Galpha-subunit 1, and prephenate dehydratase 1 are required for blue light-induced production of phenylalanine in etiolated Arabidopsis. Warpeha KM, et al. Plant Physiol, 2006 Mar. PMID 16415218, Free PMC Article
    5. Tyrosine and phenylalanine are synthesized within the plastids in Arabidopsis. Rippert P, et al. Plant Physiol, 2009 Mar. PMID 19136569, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plastid Deficient 1 Is Essential for the Accumulation of Plastid-Encoded RNA Polymerase Core Subunit beta and Chloroplast Development in Arabidopsis.
      Title: Plastid Deficient 1 Is Essential for the Accumulation of Plastid-Encoded RNA Polymerase Core Subunit β and Chloroplast Development in Arabidopsis.
    2. ADT3 role in photosynthesis and secondary metabolism.
      Title: Reduced Arogenate Dehydratase Expression: Ramifications for Photosynthesis and Metabolism.
    3. Data show that loss of AROGENATE DEHYDRATASE3 (ADT3) disrupts cotyledon epidermal patterning by affecting the number and expansion of pavement cells and stomata cell fate specification.
      Title: The Dehydratase ADT3 Affects ROS Homeostasis and Cotyledon Development.
    4. G-protein-coupled receptor 1, G-protein Galpha-subunit 1, and prephenate dehydratase 1 form all of or part of a signal transduction mechanism responsible for the light-mediated synthesis of phenylpyruvate and phenylalanine.
      Title: G-protein-coupled receptor 1, G-protein Galpha-subunit 1, and prephenate dehydratase 1 are required for blue light-induced production of phenylalanine in etiolated Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_128342.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables arogenate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables prephenate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-phenylalanine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-phenylalanine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to low fluence blue light stimulus by blue low-fluence system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tyrosine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prephenate dehydratase 1
    NP_180350.1
    • prephenate dehydratase 1 (PD1); CONTAINS InterPro DOMAIN/s: Prephenate dehydratase (InterPro:IPR001086), Prephenate dehydratase, conserved site (InterPro:IPR018528); BEST Arabidopsis thaliana protein match is: arogenate dehydratase 6 (TAIR:AT1G08250.1); Has 7147 Blast hits to 7145 proteins in 2247 species: Archae - 179; Bacteria - 4014; Metazoa - 4; Fungi - 119; Plants - 265; Viruses - 0; Other Eukaryotes - 2566 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11856571..11858288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128342.3 → NP_180350.1  prephenate dehydratase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180350.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WNL3, Q8LAP1, Q9ZUY3
      UniProtKB/TrEMBL
      A0A178VVA2
      Conserved Domains (3) summary
      cd04905
      Location:311 → 404
      ACT_CM-PDT; C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme
      PLN02317
      Location:17 → 408
      PLN02317; arogenate dehydratase
      cd13631
      Location:120 → 301
      PBP2_Ct-PDT_like; Catalytic domain of prephenate dehydratase from Chlorobium tepidum and similar proteins, subgroup 2; the type 2 periplasmic binding protein fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZUY3.1

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