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    BCAT-1 branched-chain amino acid transaminase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837542, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BCAT-1
    Official Full Name
    branched-chain amino acid transaminase 1
    Primary source
    TAIR:AT1G10060
    Locus tag
    AT1G10060
    See related
    Araport:AT1G10060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATBCAT-1; BCAT1; branched-chain amino acid transaminase 1; branched-chain amino acid transferase 1; T27I1.8; T27I1_8
    Summary
    encodes a mitochondrial branched-chain amino acid aminotransferase. Complements the yeast leu/iso-leu/val auxotrophy mutant.
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    Genomic context

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    See BCAT-1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (3284073..3287292)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ergosterol biosynthesis protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene glycosyl hydrolase family 10 protein / carbohydrate-binding domain-containing protein Neighboring gene branched-chain amino acid transaminase 2 Neighboring gene Early-responsive to dehydration stress protein (ERD4) Neighboring gene Protein prenylyltransferase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mitochondrial branched-chain aminotransferase (AtBCAT-1) is capable to initiate degradation of leucine, isoleucine and valine in almost all tissues in Arabidopsis thaliana. Schuster J, et al. Plant Mol Biol, 2005 Jan. PMID 15821880
    2. Genome-wide analysis of branched-chain amino acid levels in Arabidopsis seeds. Angelovici R, et al. Plant Cell, 2013 Dec. PMID 24368787, Free PMC Article
    3. The branched-chain amino acid transaminase gene family in Arabidopsis encodes plastid and mitochondrial proteins. Diebold R, et al. Plant Physiol, 2002 Jun. PMID 12068099, Free PMC Article
    4. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BCAT2, and not BCAT1, is the causal gene driving seed branched-chain amino acid natural variation.
      Title: Genome-wide analysis of branched-chain amino acid levels in Arabidopsis seeds.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001123785.1
    NM_001331883.1
    NM_100880.3
    NM_179298.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-isoleucine-2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-leucine-2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-valine-2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables branched-chain-amino-acid transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables branched-chain-amino-acid transaminase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-leucine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in valine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    branched-chain amino acid transaminase 1
    NP_001117257.1
    • branched-chain amino acid transaminase 1 (BCAT-1); FUNCTIONS IN: branched-chain-amino-acid transaminase activity, protein binding, catalytic activity; INVOLVED IN: branched chain family amino acid metabolic process, metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Aminotransferase, class IV (InterPro:IPR001544), Aminotransferase, class IV, conserved site (InterPro:IPR018300), Branched-chain amino acid aminotransferase II (InterPro:IPR005786); BEST Arabidopsis thaliana protein match is: branched-chain amino acid transaminase 2 (TAIR:AT1G10070.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_563859.1
    • branched-chain amino acid transaminase 1 (BCAT-1); FUNCTIONS IN: branched-chain-amino-acid transaminase activity, protein binding, catalytic activity; INVOLVED IN: branched chain family amino acid metabolic process, metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Aminotransferase, class IV (InterPro:IPR001544), Aminotransferase, class IV, conserved site (InterPro:IPR018300), Branched-chain amino acid aminotransferase II (InterPro:IPR005786); BEST Arabidopsis thaliana protein match is: branched-chain amino acid transaminase 2 (TAIR:AT1G10070.2); Has 6519 Blast hits to 6519 proteins in 2279 species: Archae - 103; Bacteria - 4487; Metazoa - 263; Fungi - 384; Plants - 208; Viruses - 0; Other Eukaryotes - 1074 (source: NCBI BLink).
    NP_849629.1
    • branched-chain amino acid transaminase 1 (BCAT-1); FUNCTIONS IN: branched-chain-amino-acid transaminase activity, protein binding, catalytic activity; INVOLVED IN: branched chain family amino acid metabolic process, metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Aminotransferase, class IV (InterPro:IPR001544), Aminotransferase, class IV, conserved site (InterPro:IPR018300), Branched-chain amino acid aminotransferase II (InterPro:IPR005786); BEST Arabidopsis thaliana protein match is: branched-chain amino acid transaminase 2 (TAIR:AT1G10070.2); Has 12211 Blast hits to 12211 proteins in 2505 species: Archae - 154; Bacteria - 7688; Metazoa - 265; Fungi - 412; Plants - 248; Viruses - 0; Other Eukaryotes - 3444 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3284073..3287292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331880.1 → NP_001320930.1  branched-chain amino acid transaminase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8APA3

    2. NM_001331881.1 → NP_001320929.1  branched-chain amino acid transaminase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WHD8, A0A1P8APA5

    3. NM_001331882.1 → NP_001320928.1  branched-chain amino acid transaminase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8APB7

    4. NM_179298.2 → NP_849629.1  branched-chain amino acid transaminase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849629.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80597, Q93Y32
      UniProtKB/TrEMBL
      A0A178WHD8, B9DFH1
      Conserved Domains (2) summary
      PLN02883
      Location:1 → 384
      PLN02883; Branched-chain amino acid aminotransferase
      cd01557
      Location:90 → 371
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

    5. NM_100880.3 → NP_563859.1  branched-chain amino acid transaminase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563859.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4I2Q0
      Conserved Domains (1) summary
      cl00224
      Location:90 → 296
      PLPDE_IV; PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate ...

    6. NM_001331883.1 → NP_001320927.1  branched-chain amino acid transaminase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WHD8, A0A1P8APE4

    7. NM_001123785.1 → NP_001117257.1  branched-chain amino acid transaminase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001117257.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654EAD5, B3H7M6
      Conserved Domains (1) summary
      cd01557
      Location:24 → 305
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93Y32.2

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