NUDT6 nudix hydrolase homolog 6 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: NUDT6
Official Full Name: nudix hydrolase homolog 6
Primary source: TAIR:AT2G04450
Locus tag: AT2G04450
See related: Araport:AT2G04450
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: Arabidopsis thaliana nucleoside diphosphate linked to some moiety X 6; Arabidopsis thaliana nucleoside diphosphate linked to some moiety X 6; ATNUDT6; ATNUDX6; nucleoside diphosphates linked to some moiety X 6; nucleoside diphosphates linked to some moiety X 6; nudix hydrolase homolog 6; NUDX6; T1O3.14; T1O3_14
Summary: Encodes a protein with NADH pyrophosphatase activity. Although this protein was also shown to have ADP-ribose diphosphatase activity in vitro, mutant analyses suggest that NUDX6 is involved in NADH metabolism in vivo.
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Genomic context

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See NUDT6 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 9

Sequence:: Chromosome: 2; NC_003071.7 (1543320..1545535)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the effects of the transient expression of the active and inactive forms of AtNUDX6 and 7 under the control of an estrogen (ES)-inducible system on various stress responses, were examined
Title: Modulation of NADH Levels by Arabidopsis Nudix Hydrolases, AtNUDX6 and 7, and the Respective Proteins Themselves Play Distinct Roles in the Regulation of Various Cellular Responses Involved in Biotic/Abiotic Stresses.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_126478.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ADP-ribose diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD binding	IDA Inferred from Direct Assay more info	PubMed
enables NAD+ diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables NADH pyrophosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of salicylic acid mediated signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to other organism	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISM Inferred from Sequence Model more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: nudix hydrolase homolog 6

NP_178526.1

nudix hydrolase homolog 6 (NUDT6); FUNCTIONS IN: hydrolase activity, ADP-ribose diphosphatase activity, NAD or NADH binding, NADH pyrophosphatase activity; INVOLVED IN: response to other organism, positive regulation of salicylic acid mediated signaling pathway; LOCATED IN: cytosol; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), NUDIX hydrolase, conserved site (InterPro:IPR020084), Nudix hydrolase 6-like (InterPro:IPR003293), NUDIX hydrolase domain (InterPro:IPR000086); BEST Arabidopsis thaliana protein match is: MutT/nudix family protein (TAIR:AT4G12720.3); Has 2998 Blast hits to 2996 proteins in 719 species: Archae - 33; Bacteria - 1649; Metazoa - 236; Fungi - 25; Plants - 166; Viruses - 14; Other Eukaryotes - 875 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

1543320..1545535

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_126478.4 → NP_178526.1 nudix hydrolase homolog 6 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_178526.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SJC4

UniProtKB/TrEMBL

A0A5S9WX54, A0A654ERV1

Conserved Domains (2) summary

cd04670
Location:102 → 235

Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

pfam18290
Location:11 → 89

Nudix_hydro; Nudix hydrolase domain