ABH1 ARM repeat superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ABH1
Official Full Name: ARM repeat superfamily protein
Primary source: TAIR:AT2G13540
Locus tag: AT2G13540
See related: Araport:AT2G13540
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ABA HYPERSENSITIVE 1; ATCBP80; CAP-BINDING PROTEIN 80; CBP80; ENS; ENSALADA; NUCLEAR CAP-BINDING PROTEIN CBP80; T10F5.8; T10F5_8
Summary: Encodes a nuclear cap-binding protein that forms a heterodimeric complex with CBP20 and is involved in ABA signaling and flowering. Mutants are early flowering and exhibit hypersensitive response to ABA in germination inhibition.Loss of ABH1 function results in abnormal processing of mRNAs for several important floral regulators (FLC, CO, FLM). Analysis of loss of function mutations suggests a role in pri-miRNA processing and mRNA splicing. Note that two different mutant alleles were given the same name abh1-7 (Kuhn et al 2007; Kim et al 2008). To avoid confusion, abh1-7 described in Kim et al (2008) has been renamed abh1-107 (other names: ensalada-1, ens-1).
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Genomic context

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See ABH1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 18

Sequence:: Chromosome: 2; NC_003071.7 (5636884..5643066)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the identification of new genes involved in ABA-dependent abiotic stresses using Arabidopsis suppressor mutants of abh1 hypersensitivity to ABA during seed germination.
Title: Towards the identification of new genes involved in ABA-dependent abiotic stresses using Arabidopsis suppressor mutants of abh1 hypersensitivity to ABA during seed germination.
Data suggest that CBP20 and CBP80 (ABH1) have synergistic roles during the salt stress response.
Title: Quantitative proteomics analysis reveals that the nuclear cap-binding complex proteins arabidopsis CBP20 and CBP80 modulate the salt stress response.
SERRATE, CAP BINDING PROTEIN20 (CBP20), and CBP80 are regulators of lincRNA expression and biogenesis. RT-PCR experiments confirmed these three proteins are also needed for splicing of a small group of intron-containing lincRNAs.
Title: Genome-wide analysis uncovers regulation of long intergenic noncoding RNAs in Arabidopsis.
This intron suppression of transgene silencing requires efficient intron splicing and is dependent on ABH1.
Title: Intron splicing suppresses RNA silencing in Arabidopsis.
ABH1 (CBP80) encodes a large subunit of CBC (CAP BINDING COMPLEX) and the abh1 mutant is drought-tolerant and hypersensitive to ABA during seed germination.
Title: Arabidopsis suppressor mutant of abh1 shows a new face of the already known players: ABH1 (CBP80) and ABI4-in response to ABA and abiotic stresses during seed germination.
The cbp80(abh1) and cbp20/80 mutants had many more changes in alternative splicing in common than did cbp20 and cbp20/80 suggesting that CBP80 plays a more significant role in alternative splicing than CBP20.
Title: Involvement of the nuclear cap-binding protein complex in alternative splicing in Arabidopsis thaliana.
AtCBP80 is required for the stability of AtCBP20 in the plant cell.
Title: The Arabidopsis CBP20 targets the cap-binding complex to the nucleus, and is stabilized by CBP80.
CBP20 and CBP80 function in miRNA biogenesis by binding to pri-miRNA transcripts, and are stabilized by ABA by a post-translational mechanism.
Title: Two cap-binding proteins CBP20 and CBP80 are involved in processing primary MicroRNAs.
Abh1 lesion affects several developmental processes, perhaps because the processing of certain mRNAs.
Title: Lesions in the mRNA cap-binding gene ABA HYPERSENSITIVE 1 suppress FRIGIDA-mediated delayed flowering in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_126934.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables RNA cap binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing, via endonucleolytic cleavage and ligation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within long-day photoperiodism, flowering	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant organ morphogenesis	NAS Non-traceable Author Statement more info
acts_upstream_of_or_within primary miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: ARM repeat superfamily protein

NP_565356.1

ABA HYPERSENSITIVE 1 (ABH1); CONTAINS InterPro DOMAIN/s: MIF4G-like, type 2 (InterPro:IPR015174), MIF4G-like, type 1 (InterPro:IPR015172), Armadillo-type fold (InterPro:IPR016024), MIF4G-like, type 3 (InterPro:IPR003890), MIF4-like, type 1/2/3 (InterPro:IPR016021); Has 514 Blast hits to 510 proteins in 229 species: Archae - 0; Bacteria - 96; Metazoa - 188; Fungi - 131; Plants - 55; Viruses - 0; Other Eukaryotes - 44 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

5636884..5643066

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_126934.4 → NP_565356.1 ARM repeat superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565356.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8VZH3, Q9LKN6, Q9SIU2

UniProtKB/TrEMBL

A0A654EXP4

Conserved Domains (3) summary

pfam02854
Location:20 → 197

MIF4G; MIF4G domain

pfam09088
Location:304 → 466

MIF4G_like; MIF4G like

pfam09090
Location:503 → 679

MIF4G_like_2; MIF4G like