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    NTMC2T2.1 Calcium-dependent lipid-binding (CaLB domain) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837052, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NTMC2T2.1
    Official Full Name
    Calcium-dependent lipid-binding (CaLB domain) family protein
    Primary source
    TAIR:AT1G05500
    Locus tag
    AT1G05500
    See related
    Araport:AT1G05500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA SYNAPTOTAGMIN HOMOLOG E; ATSYTE; NTMC2TYPE2.1; synaptotagmin 5; SYNAPTOTAGMIN HOMOLOG E; SYT5; SYTE; T25N20.15
    Summary
    Encodes a endomembrane-localized synaptotagmin. Synaptotagmin family proteins are calcium sensors that regulate exocytosis in mammalian cells.
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    Genomic context

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    See NTMC2T2.1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (1624919..1629289)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene DNAse I-like superfamily protein Neighboring gene chromatin remodeling 31 Neighboring gene naphthalene 1,2-dioxygenase subunit alpha (DUF1264) Neighboring gene Sec23/Sec24 protein transport family protein Neighboring gene UDP-glucosyl transferase 75B2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synaptotagmin 5 Controls SYP132-VAMP721/722 Interaction for Arabidopsis Immunity to Pseudomonas syringae pv tomato DC3000. Kim S, et al. Mol Cells, 2021 Sep 30. PMID 34504049, Free PMC Article
    2. Synaptotagmin 4 and 5 additively contribute to Arabidopsis immunity to Pseudomonas syringae DC3000. Kim S, et al. Plant Signal Behav, 2022 Dec 31. PMID 35060423, Free PMC Article
    3. Arabidopsis synaptotagmin SYT1, a type I signal-anchor protein, requires tandem C2 domains for delivery to the plasma membrane. Yamazaki T, et al. J Biol Chem, 2010 Jul 23. PMID 20498364, Free PMC Article
    4. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article
    5. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synaptotagmin 4 and 5 additively contribute to Arabidopsis immunity to Pseudomonas syringae DC3000.
      Title: Synaptotagmin 4 and 5 additively contribute to Arabidopsis immunity to Pseudomonas syringae DC3000.
    2. Synaptotagmin 5 Controls SYP132-VAMP721/722 Interaction for Arabidopsis Immunity to Pseudomonas syringae pv tomato DC3000.
      Title: Synaptotagmin 5 Controls SYP132-VAMP721/722 Interaction for Arabidopsis Immunity to Pseudomonas syringae pv tomato DC3000.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001331551.1
    NM_100429.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in perinuclear theca IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    Calcium-dependent lipid-binding (CaLB domain) family protein
    NP_172041.2
    • NTMC2T2.1; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: endomembrane system, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), C2 region (InterPro:IPR020477), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: Calcium-dependent lipid-binding (CaLB domain) family protein (TAIR:AT5G11100.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      1624919..1629289
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100429.3 → NP_172041.2  Calcium-dependent lipid-binding (CaLB domain) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172041.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L706, Q9ZVY8
      UniProtKB/TrEMBL
      A0A5S9SR98, A0A654E822
      Conserved Domains (2) summary
      pfam00168
      Location:435 → 537
      C2; C2 domain
      pfam17047
      Location:67 → 249
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    2. NM_001331551.1 → NP_001320996.1  Calcium-dependent lipid-binding (CaLB domain) family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8APH4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L706.1

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