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    LPP2 lipid phosphate phosphatase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838072, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LPP2
    Official Full Name
    lipid phosphate phosphatase 2
    Primary source
    TAIR:AT1G15080
    Locus tag
    AT1G15080
    See related
    Araport:AT1G15080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATLPP2; ATPAP2; F9L1.2; F9L1_2; lipid phosphate phosphatase 2; LIPID PHOSPHATE PHOSPHATASE 2; PHOSPHATIDIC ACID PHOSPHATASE 2
    Summary
    Encodes phosphatidic acid phosphatase. Involved in ABA signaling. Functions as a negative regulator upstream of ABI4. Expressed during germination and seed development. Expressed overall in young seedlings, in roots, hypocotyls, and vascular cells of cotyledons and leaves of 10 day-old seedlings, in flower filaments and stem elongation zones. Not expressed in anthers, pollen nor petals.
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    Genomic context

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    See LPP2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (5187549..5189673)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Class I glutamine amidotransferase-like superfamily protein Neighboring gene ncRNA Neighboring gene indole-3-acetic acid inducible 34 Neighboring gene alpha/beta hydrolase family protein Neighboring gene tRNA-Asn Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis thaliana lipid phosphate phosphatase 2 is involved in abscisic acid signalling in leaves. Paradis S, et al. Plant Physiol Biochem, 2011 Mar. PMID 21277215
    2. An important role of phosphatidic acid in ABA signaling during germination in Arabidopsis thaliana. Katagiri T, et al. Plant J, 2005 Jul. PMID 15960620
    3. Lipid phosphate phosphatases in Arabidopsis. Regulation of the AtLPP1 gene in response to stress. Pierrugues O, et al. J Biol Chem, 2001 Jun 8. PMID 11278556
    4. Expression patterns of purple acid phosphatase genes in Arabidopsis organs and functional analysis of AtPAP23 predominantly transcribed in flower. Zhu H, et al. Plant Mol Biol, 2005 Nov. PMID 16244908
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Taken together our observations show that AtLPP2 is a part of ABA signalling and participate to the regulation of stomatal movements.
      Title: Arabidopsis thaliana lipid phosphate phosphatase 2 is involved in abscisic acid signalling in leaves.
    2. Two AtLPP2 T-DNA insertional mutants (lpp2-1 and lpp2-2) showed hypersensitivity to ABA and significant PA accumulation during germination. [AtLPP2]
      Title: An important role of phosphatidic acid in ABA signaling during germination in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101377.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables acid phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphatidate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid-activated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    lipid phosphate phosphatase 2
    NP_172961.1
    • lipid phosphate phosphatase 2 (LPP2); FUNCTIONS IN: acid phosphatase activity, phosphatidate phosphatase activity; INVOLVED IN: abscisic acid mediated signaling pathway; LOCATED IN: plasma membrane, integral to plasma membrane; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Phosphatidic acid phosphatase/chloroperoxidase, N-terminal (InterPro:IPR016118), Phosphatidic acid phosphatase type 2/haloperoxidase (InterPro:IPR000326); BEST Arabidopsis thaliana protein match is: lipid phosphate phosphatase 3 (TAIR:AT3G02600.5); Has 2086 Blast hits to 2081 proteins in 377 species: Archae - 13; Bacteria - 320; Metazoa - 928; Fungi - 399; Plants - 199; Viruses - 3; Other Eukaryotes - 224 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5187549..5189673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101377.5 → NP_172961.1  lipid phosphate phosphatase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172961.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XI60
      UniProtKB/TrEMBL
      A0A5S9UI08, A0A654EB10, A0A7G2DTU4
      Conserved Domains (1) summary
      PLN02250
      Location:1 → 290
      PLN02250; lipid phosphate phosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XI60.1

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