ARC3 GTP binding protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ARC3
Official Full Name: GTP binding protein
Primary source: TAIR:AT1G75010
Locus tag: AT1G75010
See related: Araport:AT1G75010
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ACCUMULATION AND REPLICATION OF CHLOROPLASTS 3; F25A4.3; F25A4_3
Summary: Encodes ARC3 (Accumulation and Replication of Chloroplast 3), a chloroplast division factor functioning in the initiation of chloroplast division. ARC3 is a chimera of the prokaryotic FtsZ and part of the eukaryotic phosphatidylinositol-4-phosphate 5-kinase (PIP5K). Located on the outer surface of the chloroplast in a ring-like structure at the early stage of chloroplast division. The arc3 mutant has a small number of abnormally large chloroplasts in the cell.
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Genomic context

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See ARC3 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 15

Sequence:: Chromosome: 1; NC_003070.9 (28164828..28170113, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OR(His), a Natural Variant of OR, Specifically Interacts with Plastid Division Factor ARC3 to Regulate Chromoplast Number and Carotenoid Accumulation.
Title: OR(His), a Natural Variant of OR, Specifically Interacts with Plastid Division Factor ARC3 to Regulate Chromoplast Number and Carotenoid Accumulation.
Chloroplast division protein ARC3 acts on FtsZ2 by preventing filament bundling and enhancing GTPase activity.
Title: Chloroplast division protein ARC3 acts on FtsZ2 by preventing filament bundling and enhancing GTPase activity.
In plants lacking ARC3, the key negative regulator of FtsZ assembly, FtsZ1/FtsZ2 turnover was threefold slower.
Title: FtsZ1/FtsZ2 Turnover in Chloroplasts and the Role of ARC3.
Results suggest that ARC3 directly inhibits Z-ring assembly through interaction with FtsZ2 in heteropolymers and that ARC3 activity is spatially regulated by MinD1 and MinE1 to permit Z-ring assembly at the mid-plastid.
Title: Chloroplast division protein ARC3 regulates chloroplast FtsZ-ring assembly and positioning in arabidopsis through interaction with FtsZ2.
Two new alleles of arc3 in Arabidopsis thaliana, arc3-4 and arc3-5, were isolated in the Columbia-0 ecotype.
Title: Genetic mapping and isolation of two arc3 alleles in Arabidopsis.
Transgenic and genetic analyses revealed that this organelle abnormality was not linked to etr1-1 or ethylene signaling, but linked to a second mutation in ARC3, which was further verified by genetic complementation analysis.
Title: Giant chloroplast development in ethylene response1-1 is caused by a second mutation in ACCUMULATION AND REPLICATION OF CHLOROPLAST3 in Arabidopsis.
In hypocotyls, the effects of the arc3 and arc6 mutations on stromule length and frequency are independent of changes in plastid division. [ARC3]
Title: Effects of arc3, arc5 and arc6 mutations on plastid morphology and stromule formation in green and nongreen tissues of Arabidopsis thaliana.
FtsZ1-FtsZ2-ARC3-ARC6 complex represents an unpolymerized IEM-associated pool of FtsZ that contributes to the dynamic regulation of Z-ring assembly and remodelling at the plastid division site in vivo. [ARC3]
Title: In vivo quantitative relationship between plastid division proteins FtsZ1 and FtsZ2 and identification of ARC6 and ARC3 in a native FtsZ complex.
ARC3 is a stromal Z-ring accessory protein that interacts specifically with AtFtsZ1, and is essential for plastid division. [ARC3]
Title: ARC3 is a stromal Z-ring accessory protein essential for plastid division.
Arc3 encodes a chloroplast division factor and arc mutants have large but fewer chloroplasts which have an effect on both the composition and structure of the photosynthetic apparatus. [ARC3]
Title: Photosynthesis in Arabidopsis thaliana mutants with reduced chloroplast number.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_106158.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloroplast fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloroplast fission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plastid organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast stroma	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed

General protein information

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Preferred Names: GTP binding protein

NP_177638.2

ACCUMULATION AND REPLICATION OF CHLOROPLASTS 3 (ARC3); FUNCTIONS IN: GTP binding; INVOLVED IN: plastid organization, chloroplast fission; LOCATED IN: chloroplast stroma; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cell division protein FtsZ, N-terminal (InterPro:IPR000158), Tubulin/FtsZ, N-terminal (InterPro:IPR019746), MORN motif (InterPro:IPR003409); BEST Arabidopsis thaliana protein match is: Phosphatidylinositol-4-phosphate 5-kinase family protein (TAIR:AT1G60890.1); Has 25195 Blast hits to 11716 proteins in 2589 species: Archae - 74; Bacteria - 8050; Metazoa - 1670; Fungi - 101; Plants - 2147; Viruses - 0; Other Eukaryotes - 13153 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

28164828..28170113 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_106158.5 → NP_177638.2 GTP binding protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_177638.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WT28, Q6F6B5, Q9C9P7, Q9SSG9

UniProtKB/TrEMBL

A0A654EU76

Conserved Domains (3) summary

COG4642
Location:605 → 711

COG4642; Uncharacterized conserved protein [Function unknown]

pfam02493
Location:630 → 652

MORN; MORN repeat

cl10017
Location:163 → 361

Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like