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    TTL1 tetratricopetide-repeat thioredoxin-like 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841764, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TTL1
    Official Full Name
    tetratricopetide-repeat thioredoxin-like 1
    Primary source
    TAIR:AT1G53300
    Locus tag
    AT1G53300
    See related
    Araport:AT1G53300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F12M16.20; F12M16_20; tetratricopeptide-repeat thioredoxin-like 1; tetratricopetide-repeat thioredoxin-like 1
    Summary
    Encodes one of the 36 carboxylate clamp (CC)-tetratricopeptide repeat (TPR) proteins (Prasad 2010, Pubmed ID: 20856808) with potential to interact with Hsp90/Hsp70 as co-chaperones. The TTL family is required for osmotic stress tolerance and male sporogenesis.
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    Genomic context

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    See TTL1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (19879405..19882895)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene plant thionin family protein Neighboring gene Galactosyltransferase family protein Neighboring gene phosphoenolpyruvate carboxylase 1 Neighboring gene tubby like protein 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis TETRATRICOPEPTIDE THIOREDOXIN-LIKE 1 Gene Is Involved in Anisotropic Root Growth during Osmotic Stress Adaptation. Cuadrado-Pedetti MB, et al. Genes (Basel), 2021 Feb 7. PMID 33562207, Free PMC Article
    2. The Arabidopsis tetratricopeptide repeat-containing protein TTL1 is required for osmotic stress responses and abscisic acid sensitivity. Rosado A, et al. Plant Physiol, 2006 Nov. PMID 16998088, Free PMC Article
    3. The Arabidopsis tetratricopeptide thioredoxin-like gene family is required for osmotic stress tolerance and male sporogenesis. Lakhssassi N, et al. Plant Physiol, 2012 Mar. PMID 22232384, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis TETRATRICOPEPTIDE THIOREDOXIN-LIKE 1 Gene Is Involved in Anisotropic Root Growth during Osmotic Stress Adaptation.
      Title: The Arabidopsis TETRATRICOPEPTIDE THIOREDOXIN-LIKE 1 Gene Is Involved in Anisotropic Root Growth during Osmotic Stress Adaptation.
    2. TTL1 was identified as a positive regulator of abscisic signaling during germination and seedling development under stress.
      Title: The Arabidopsis tetratricopeptide repeat-containing protein TTL1 is required for osmotic stress responses and abscisic acid sensitivity.
    Submit: New GeneRIF Correction

    General gene information

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    NM_104208.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopetide-repeat thioredoxin-like 1
    NP_175737.1
    • tetratricopetide-repeat thioredoxin-like 1 (TTL1); FUNCTIONS IN: binding; INVOLVED IN: cell redox homeostasis; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Molecular chaperone, heat shock protein, Hsp40, DnaJ (InterPro:IPR015609), Tetratricopeptide TPR-1 (InterPro:IPR001440), Thioredoxin fold (InterPro:IPR012335), Tetratricopeptide-like helical (InterPro:IPR011990), Thioredoxin domain (InterPro:IPR013766), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: tetratricopetide-repeat thioredoxin-like 2 (TAIR:AT3G14950.1); Has 32097 Blast hits to 15852 proteins in 1300 species: Archae - 552; Bacteria - 6287; Metazoa - 8110; Fungi - 3609; Plants - 2668; Viruses - 128; Other Eukaryotes - 10743 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19879405..19882895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104208.3 → NP_175737.1  tetratricopetide-repeat thioredoxin-like 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175737.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9MAH1
      UniProtKB/TrEMBL
      A0A178W6A1, A0A5S9WP96
      Conserved Domains (5) summary
      smart00028
      Location:499 → 532
      TPR; Tetratricopeptide repeats
      cd02947
      Location:604 → 691
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      sd00006
      Location:469 → 493
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:468 → 530
      TPR_11; TPR repeat
      pfam13431
      Location:284 → 316
      TPR_17; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MAH1.1

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