U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ATX1 homolog of anti-oxidant 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842940, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ATX1
    Official Full Name
    homolog of anti-oxidant 1
    Primary source
    TAIR:AT1G66240
    Locus tag
    AT1G66240
    See related
    Araport:AT1G66240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATATX1; homolog of anti-oxidant 1; T6J19.6; T6J19_6
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ATX1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (24686114..24687417, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene myb domain protein 20 Neighboring gene no-apical-meristem-associated carboxy-terminal domain protein Neighboring gene miscRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Copper chaperone antioxidant protein1 is essential for copper homeostasis. Shin LJ, et al. Plant Physiol, 2012 Jul. PMID 22555879, Free PMC Article
    2. Higher plants possess two different types of ATX1-like copper chaperones. Puig S, et al. Biochem Biophys Res Commun, 2007 Mar 9. PMID 17223078
    3. ARABIDOPSIS TRITHORAX-RELATED7 is required for methylation of lysine 4 of histone H3 and for transcriptional activation of FLOWERING LOCUS C. Tamada Y, et al. Plant Cell, 2009 Oct. PMID 19855050, Free PMC Article
    4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATX1 plays an essential role in copper (Cu) homeostasis in conferring tolerance to excess Cu and Cu deficiency.
      Title: Copper chaperone antioxidant protein1 is essential for copper homeostasis.
    2. Both classes of H3K4 methylases, atx1 and atxr7, appear to be required for proper regulation of FLC expression.
      Title: ARABIDOPSIS TRITHORAX-RELATED7 is required for methylation of lysine 4 of histone H3 and for transcriptional activation of FLOWERING LOCUS C.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_001160981.2
    NM_001198399.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in secretory vesicle HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    homolog of anti-oxidant 1
    NP_001154453.1
    • homolog of anti-oxidant 1 (ATX1); FUNCTIONS IN: metal ion binding; INVOLVED IN: metal ion transport; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121); BEST Arabidopsis thaliana protein match is: copper chaperone (TAIR:AT3G56240.1); Has 1418 Blast hits to 1416 proteins in 230 species: Archae - 2; Bacteria - 113; Metazoa - 138; Fungi - 209; Plants - 939; Viruses - 0; Other Eukaryotes - 17 (source: NCBI BLink).
    NP_001185328.1
    • homolog of anti-oxidant 1 (ATX1); LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages.
    NP_564870.1
    • homolog of anti-oxidant 1 (ATX1); FUNCTIONS IN: metal ion binding; INVOLVED IN: metal ion transport; LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121); BEST Arabidopsis thaliana protein match is: copper chaperone (TAIR:AT3G56240.1); Has 1720 Blast hits to 1673 proteins in 288 species: Archae - 4; Bacteria - 215; Metazoa - 140; Fungi - 221; Plants - 1117; Viruses - 0; Other Eukaryotes - 23 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24686114..24687417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105295.4 → NP_564870.1  homolog of anti-oxidant 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564870.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94BT9
      Conserved Domains (1) summary
      cd00371
      Location:36 → 93
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

    2. NM_001198399.1 → NP_001185328.1  homolog of anti-oxidant 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4ID99

    3. NM_001160981.2 → NP_001154453.1  homolog of anti-oxidant 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154453.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z3B8, Q94BT9, Q9C7U6
      UniProtKB/TrEMBL
      A0A5S9WSJ8, A0A654ERK7, A0A7G2E3N6
      Conserved Domains (1) summary
      cd00371
      Location:1 → 53
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.