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    RFC3 replication factor C subunit 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844083, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RFC3
    Official Full Name
    replication factor C subunit 3
    Primary source
    TAIR:AT1G77470
    Locus tag
    AT1G77470
    See related
    Araport:AT1G77470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EMB2810; EMBRYO DEFECTIVE 2810; replication factor C 5; replication factor C subunit 3; RFC5; T5M16.6; T5M16_6
    Summary
    Encodes a protein with high homology to the Replication Factor C, Subunit 3 (RFC3) of yeast and other eukaryotes. rfc3 mutants are hypersensitive to salicylic acid and exhibit enhanced induction of PR genes and resistance against virulent oomycete Hyaloperonospora arabidopsidis Noco2. The enhanced pathogen resistance in the mutant is NPR1-independent.
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    Genomic context

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    See RFC3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (29111948..29114548, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene NAC domain containing protein 32 Neighboring gene CELLULOSE SYNTHASE INTERACTIVE 3 Neighboring gene Eukaryotic aspartyl protease family protein Neighboring gene thylakoidal ascorbate peroxidase Neighboring gene DUF630 family protein, putative (DUF630 and DUF632)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Negative regulation of systemic acquired resistance by replication factor C subunit3 in Arabidopsis. Xia S, et al. Plant Physiol, 2009 Aug. PMID 19482917, Free PMC Article
    2. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
    3. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_106396.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    replication factor C subunit 3
    NP_177871.1
    • replication factor C subunit 3 (RFC3); FUNCTIONS IN: in 6 functions; INVOLVED IN: negative regulation of defense response; LOCATED IN: DNA replication factor C complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-type, core (InterPro:IPR003959), Replication factor C (InterPro:IPR013748), DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal (InterPro:IPR008921); BEST Arabidopsis thaliana protein match is: ATPase family associated with various cellular activities (AAA) (TAIR:AT1G21690.1); Has 17584 Blast hits to 17541 proteins in 2810 species: Archae - 637; Bacteria - 9895; Metazoa - 902; Fungi - 991; Plants - 392; Viruses - 88; Other Eukaryotes - 4679 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29111948..29114548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106396.5 → NP_177871.1  replication factor C subunit 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177871.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9CAQ8
      UniProtKB/TrEMBL
      A0A178WIQ9, A0A5S9WV60, A0A7G2E6K0
      Conserved Domains (1) summary
      PRK00440
      Location:39 → 357
      rfc; replication factor C small subunit; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CAQ8.1

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