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    ARF6 auxin response factor 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839913, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARF6
    Official Full Name
    auxin response factor 6
    Primary source
    TAIR:AT1G30330
    Locus tag
    AT1G30330
    See related
    Araport:AT1G30330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    auxin response factor 6; T4K22.6; T4K22_6
    Summary
    Encodes a member of the auxin response factor family. Mediates auxin response via expression of auxin regulated genes. Acts redundantly with ARF8 to control stamen elongation and flower maturation. Expression of ARF6 is controlled by miR167.
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    Genomic context

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    See ARF6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (10685822..10690988, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene Remorin family protein Neighboring gene pseudo Neighboring gene Pectin lyase-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cellular expression map of the Arabidopsis AUXIN RESPONSE FACTOR gene family. Rademacher EH, et al. Plant J, 2011 Nov. PMID 21831209
    2. A crosstalk between auxin and brassinosteroid regulates leaf shape by modulating growth anisotropy. Xiong Y, et al. Mol Plant, 2021 Jun 7. PMID 33722761
    3. Auxin response factors ARF6 and ARF8 promote jasmonic acid production and flower maturation. Nagpal P, et al. Development, 2005 Sep. PMID 16107481
    4. Arabidopsis auxin response factor6 and 8 regulate jasmonic acid biosynthesis and floral organ development via repression of class 1 KNOX genes. Tabata R, et al. Plant Cell Physiol, 2010 Jan. PMID 20007966
    5. Plant fertility defects induced by the enhanced expression of microRNA167. Ru P, et al. Cell Res, 2006 May. PMID 16699541

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A crosstalk between auxin and brassinosteroid regulates leaf shape by modulating growth anisotropy.
      Title: A crosstalk between auxin and brassinosteroid regulates leaf shape by modulating growth anisotropy.
    2. Photoexcited CRY1 and phyB interact directly with ARF6 and ARF8 to regulate their DNA-binding activity and auxin-induced hypocotyl elongation in Arabidopsis.
      Title: Photoexcited CRY1 and phyB interact directly with ARF6 and ARF8 to regulate their DNA-binding activity and auxin-induced hypocotyl elongation in Arabidopsis.
    3. found that hypocotyl cell elongation is regulated by a network involving ethylene, auxin, and BR signalling, which is mediated by interactions among ERF72, ARF6, and BZR1. ERF72 interacted directly with ARF6 and BZR1 in vitro and in vivo, and it antagonised regulation by ARF6 and BZR1 of the transcription of BEE3 and XTH7
      Title: ERF72 interacts with ARF6 and BZR1 to regulate hypocotyl elongation in Arabidopsis.
    4. Ectopic expression of UGT84A2 delayed flowering by indole-3-butyric acid-mediated transcriptional repression of ARF6 and ARF8 genes in Arabidopsis
      Title: Ectopic expression of UGT84A2 delayed flowering by indole-3-butyric acid-mediated transcriptional repression of ARF6 and ARF8 genes in Arabidopsis.
    5. We concluded that ARF6 and ARF8, in parallel with AS1 and AS2, repress the class 1 KNOX genes in developing floral organs to allow progression of the development of these organs.
      Title: Arabidopsis auxin response factor6 and 8 regulate jasmonic acid biosynthesis and floral organ development via repression of class 1 KNOX genes.
    6. Phenotypic plasticity of adventitious rooting is controlled by complex regulation of AUXIN RESPONSE FACTOR transcripts and microRNA abundance. ARF6 and ARF8, targets of miR167, are positive regulators.
      Title: Phenotypic plasticity of adventitious rooting in Arabidopsis is controlled by complex regulation of AUXIN RESPONSE FACTOR transcripts and microRNA abundance.
    7. Auxin response factors ARF6 and ARF8 promote jasmonic acid production, while their gene dosage affects the timing of flower maturation.
      Title: Auxin response factors ARF6 and ARF8 promote jasmonic acid production and flower maturation.
    8. Data show that Arabidopsis microRNA167 controls patterns of ARF6 and ARF8 expression, and regulates both female and male reproduction.
      Title: Arabidopsis microRNA167 controls patterns of ARF6 and ARF8 expression, and regulates both female and male reproduction.
    9. Enhance expression of microRNA, miR167, which has a complementary sequence to a portion of the AUXIN RESPONSE FACTOR 6 (ARF6), can cause plant fertility defect.
      Title: Plant fertility defects induced by the enhanced expression of microRNA167.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Miscellaneous features

    • Loc: c10690160-10690116 AT1G30330.uORF5
    • Loc: c10690196-10690116 AT1G30330.uORF2
    • Loc: c10690261-10690151 AT1G30330.uORF1
    • Loc: c10690332-10690261 AT1G30330.uORF3
    • Loc: c10690602-10690558 AT1G30330.uORF4
    NM_001036038.2
    NM_102771.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    auxin response factor 6
    NP_001031115.1
    • auxin response factor 6 (ARF6); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: flower development, response to auxin stimulus, regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), Transcriptional factor B3 (InterPro:IPR003340), AUX/IAA protein (InterPro:IPR003311), Auxin response factor (InterPro:IPR010525); BEST Arabidopsis thaliana protein match is: auxin response factor 8 (TAIR:AT5G37020.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_174323.1
    • auxin response factor 6 (ARF6); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: flower development, response to auxin stimulus, regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), Transcriptional factor B3 (InterPro:IPR003340), AUX/IAA protein (InterPro:IPR003311), Auxin response factor (InterPro:IPR010525); BEST Arabidopsis thaliana protein match is: auxin response factor 8 (TAIR:AT5G37020.1); Has 63215 Blast hits to 27346 proteins in 1335 species: Archae - 8; Bacteria - 4193; Metazoa - 21348; Fungi - 6939; Plants - 6324; Viruses - 577; Other Eukaryotes - 23826 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      10685822..10690988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332891.1 → NP_001320924.1  auxin response factor 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B2CT72, B2CT88, Q5IRX9, Q9ZTX8
      UniProtKB/TrEMBL
      A0A5S9WDQ8, A0A654EE38
      Conserved Domains (3) summary
      pfam02309
      Location:766 → 870
      AUX_IAA; AUX/IAA family
      pfam02362
      Location:129 → 231
      B3; B3 DNA binding domain
      pfam06507
      Location:261 → 338
      Auxin_resp; Auxin response factor

    2. NM_102771.4 → NP_174323.1  auxin response factor 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174323.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WDQ8
      Conserved Domains (3) summary
      pfam02309
      Location:764 → 868
      AUX_IAA; AUX/IAA family
      pfam02362
      Location:127 → 229
      B3; B3 DNA binding domain
      pfam06507
      Location:259 → 336
      Auxin_resp; Auxin response factor

    3. NM_001036038.2 → NP_001031115.1  auxin response factor 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031115.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B2CT72, B2CT88, Q5IRX9, Q9ZTX8
      UniProtKB/TrEMBL
      A0A5S9WDQ8, A0A654EE38
      Conserved Domains (3) summary
      pfam02309
      Location:766 → 870
      AUX_IAA; AUX/IAA family
      pfam02362
      Location:129 → 231
      B3; B3 DNA binding domain
      pfam06507
      Location:261 → 338
      Auxin_resp; Auxin response factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZTX8.2

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