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    HCF173 high chlorophyll fluorescence phenotype 173 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838243, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HCF173
    Official Full Name
    high chlorophyll fluorescence phenotype 173
    Primary source
    TAIR:AT1G16720
    Locus tag
    AT1G16720
    See related
    Araport:AT1G16720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F19K19.14; high chlorophyll fluorescence phenotype 173
    Summary
    Encodes HCF173, a protein with weak similarities to the superfamily of the short-chain dehydrogenases/reductases. HCF173 is involved in the initiation of translation of the psbA mRNA. Mutants shows a high chlorophyll fluorescence phenotype (hcf) and are severely affected in the accumulation of PSII subunits. The protein HCF173 is localized in the chloroplast, where it is mainly associated with the membrane system and is part of a higher molecular weight complex with psbA mRNA as a component of this complex.
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    Genomic context

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    See HCF173 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (5722891..5726478)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Alpha-helical ferredoxin Neighboring gene p300/CBP acetyltransferase-related protein-like protein Neighboring gene histone acetyltransferase of the CBP family 12 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein L20 Neighboring gene uncharacterized protein Neighboring gene GPI-anchored adhesin-like protein, putative (Protein of unknown function, DUF547)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ribonucleoprotein Capture by in Vivo Expression of a Designer Pentatricopeptide Repeat Protein in Arabidopsis. McDermott JJ, et al. Plant Cell, 2019 Aug. PMID 31123048, Free PMC Article
    2. The nuclear-encoded factor HCF173 is involved in the initiation of translation of the psbA mRNA in Arabidopsis thaliana. Schult K, et al. Plant Cell, 2007 Apr. PMID 17435084, Free PMC Article
    3. LOW PHOTOSYNTHETIC EFFICIENCY 1 is required for light-regulated photosystem II biogenesis in Arabidopsis. Jin H, et al. Proc Natl Acad Sci U S A, 2018 Jun 26. PMID 29891689, Free PMC Article
    4. The atypical short-chain dehydrogenases HCF173 and HCF244 are jointly involved in translational initiation of the psbA mRNA of Arabidopsis. Link S, et al. Plant Physiol, 2012 Dec. PMID 23027666, Free PMC Article
    5. Regulation of transcription of nucleotide-binding leucine-rich repeat-encoding genes SNC1 and RPP4 via H3K4 trimethylation. Xia S, et al. Plant Physiol, 2013 Jul. PMID 23690534, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LPE1 interacts with a known regulator of psbA mRNA translation HIGH CHLOROPHYLL FLUORESCENCE 173 (HCF173) and facilitates the association of HCF173 with psbA mRNA.
      Title: LOW PHOTOSYNTHETIC EFFICIENCY 1 is required for light-regulated photosystem II biogenesis in Arabidopsis.
    2. HCF244 was identified by coexpression analysis of HCF173, which encodes a protein that is also necessary for psbA translational initiation and in addition for stabilization of this messenger RNA.
      Title: The atypical short-chain dehydrogenases HCF173 and HCF244 are jointly involved in translational initiation of the psbA mRNA of Arabidopsis.
    3. The protein HCF173 is localized in the chloroplast, where it is mainly associated with the membrane system. It is part of a higher molecular weight complex and is essential for translation of the D1 encoding psbA mRNA. [HCF173]
      Title: The nuclear-encoded factor HCF173 is involved in the initiation of translation of the psbA mRNA in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001332253.1
    NM_001332254.1
    NM_101533.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within photosystem II assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photosystem II assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    high chlorophyll fluorescence phenotype 173
    NP_173116.1
    • high chlorophyll fluorescence phenotype 173 (HCF173); FUNCTIONS IN: binding, catalytic activity; INVOLVED IN: photosystem II assembly, translational initiation; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040), NADH:ubiquinone oxidoreductase intermediate-associated protein 30 (InterPro:IPR013857), NmrA-like (InterPro:IPR008030); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT4G18810.2); Has 1950 Blast hits to 1792 proteins in 453 species: Archae - 27; Bacteria - 1263; Metazoa - 9; Fungi - 6; Plants - 464; Viruses - 0; Other Eukaryotes - 181 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5722891..5726478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101533.4 → NP_173116.1  high chlorophyll fluorescence phenotype 173 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173116.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8W4D6
      UniProtKB/TrEMBL
      A0A178WDD3, A0A5S9USS8
      Conserved Domains (2) summary
      cl21454
      Location:164 → 560
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl21728
      Location:285 → 420
      CIA30; Complex I intermediate-associated protein 30 (CIA30)

    2. NM_001332253.1 → NP_001323375.1  high chlorophyll fluorescence phenotype 173 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WDD3, A0A1P8AWU9, A0A5S9USS8

    3. NM_001332254.1 → NP_001323376.1  high chlorophyll fluorescence phenotype 173 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WDD3, A0A1P8AWY1, A0A5S9USS8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W4D6.1

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