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    J3 DNAJ homologue 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823531, updated on 18-Sep-2024

    Summary

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    Official Symbol
    J3
    Official Full Name
    DNAJ homologue 3
    Primary source
    TAIR:AT3G44110
    Locus tag
    AT3G44110
    See related
    Araport:AT3G44110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATJ; ATJ3; DNAJ homologue 3
    Summary
    homologous to the co-chaperon DNAJ protein from E coli
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (15868631..15871256, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene MD-2-related lipid recognition domain-containing protein Neighboring gene ncRNA Neighboring gene ECA1 gametogenesis family protein (DUF784)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. J3 regulation of flowering time is mainly contributed by its activity in leaves. Shen L, et al. Plant Signal Behav, 2011 Apr. PMID 21494090, Free PMC Article
    2. HSP70-4 and farnesylated AtJ3 constitute a specific HSP70/HSP40-based chaperone machinery essential for prolonged heat stress tolerance in Arabidopsis. Wang TY, et al. J Plant Physiol, 2021 Jun. PMID 33991823
    3. The Arabidopsis chaperone J3 regulates the plasma membrane H+-ATPase through interaction with the PKS5 kinase. Yang Y, et al. Plant Cell, 2010 Apr. PMID 20418496, Free PMC Article
    4. The J-domain protein J3 mediates the integration of flowering signals in Arabidopsis. Shen L, et al. Plant Cell, 2011 Feb. PMID 21343416, Free PMC Article
    5. [The responses of AtJ2 and AtJ3 gene expression to environmental stresses in Arabidopsis]. Li GL, et al. Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao, 2005 Feb. PMID 15692178

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HSP70-4 and farnesylated AtJ3 constitute a specific HSP70/HSP40-based chaperone machinery essential for prolonged heat stress tolerance in Arabidopsis.
      Title: HSP70-4 and farnesylated AtJ3 constitute a specific HSP70/HSP40-based chaperone machinery essential for prolonged heat stress tolerance in Arabidopsis.
    2. defective farnesylation of a single factor-heat-shock protein 40 (HSP40), encoded by the J2 and J3 genes-is sufficient to confer abscisic acid hypersensitivity, drought resistance, late flowering, and enlarged meristems.
      Title: Heat-shock protein 40 is the key farnesylation target in meristem size control, abscisic acid signaling, and drought resistance.
    3. Data suggest that J3 activity in leaves mainly contributes to its role in regulating flowering time
      Title: J3 regulation of flowering time is mainly contributed by its activity in leaves.
    4. Loss of function of J3 delays flowering time in Arabidopsis, and regulates the expression of SOC1 and FT.
      Title: The J-domain protein J3 mediates the integration of flowering signals in Arabidopsis.
    5. J3 regulates plasma membrane H+-ATPase activity through interaction with the PKS5 kinase.
      Title: The Arabidopsis chaperone J3 regulates the plasma membrane H+-ATPase through interaction with the PKS5 kinase.
    6. Results indicate that the expression of AtJ2 and AtJ3 genes is involved in response to many environmental stresses except salt stress.
      Title: [The responses of AtJ2 and AtJ3 gene expression to environmental stresses in Arabidopsis].
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_114279.4
    NM_180322.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to heat IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasmic stress granule IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleolus HDA PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    DNAJ homologue 3
    NP_189997.1
    • DNAJ homologue 3 (ATJ3); FUNCTIONS IN: unfolded protein binding, heat shock protein binding, ATP binding; INVOLVED IN: protein folding, response to salt stress, regulation of ATPase activity; LOCATED IN: nucleolus, cell wall, plasma membrane; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Molecular chaperone, heat shock protein, Hsp40, DnaJ (InterPro:IPR015609), HSP40/DnaJ peptide-binding (InterPro:IPR008971), Chaperone DnaJ, C-terminal (InterPro:IPR002939), Heat shock protein DnaJ, N-terminal (InterPro:IPR001623), Heat shock protein DnaJ, cysteine-rich domain (InterPro:IPR001305), Heat shock protein DnaJ, conserved site (InterPro:IPR018253), Heat shock protein DnaJ (InterPro:IPR003095), Chaperone DnaJ (InterPro:IPR012724); BEST Arabidopsis thaliana protein match is: DNAJ homologue 2 (TAIR:AT5G22060.1); Has 26899 Blast hits to 26588 proteins in 3465 species: Archae - 213; Bacteria - 10134; Metazoa - 4292; Fungi - 2434; Plants - 2563; Viruses - 88; Other Eukaryotes - 7175 (source: NCBI BLink).
    NP_850653.1
    • DNAJ homologue 3 (ATJ3); FUNCTIONS IN: unfolded protein binding, heat shock protein binding; INVOLVED IN: protein folding, response to salt stress, regulation of ATPase activity; LOCATED IN: nucleolus, cell wall, plasma membrane; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Molecular chaperone, heat shock protein, Hsp40, DnaJ (InterPro:IPR015609), HSP40/DnaJ peptide-binding (InterPro:IPR008971), Chaperone DnaJ, C-terminal (InterPro:IPR002939), Heat shock protein DnaJ, N-terminal (InterPro:IPR001623), Heat shock protein DnaJ, conserved site (InterPro:IPR018253), Heat shock protein DnaJ, cysteine-rich domain (InterPro:IPR001305), Heat shock protein DnaJ (InterPro:IPR003095); BEST Arabidopsis thaliana protein match is: DNAJ homologue 2 (TAIR:AT5G22060.1); Has 26521 Blast hits to 26345 proteins in 3465 species: Archae - 213; Bacteria - 10015; Metazoa - 4280; Fungi - 2432; Plants - 2547; Viruses - 88; Other Eukaryotes - 6946 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      15868631..15871256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114279.4 → NP_189997.1  DNAJ homologue 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189997.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22663, Q42530, Q94AW8
      UniProtKB/TrEMBL
      A0A178VCC5, A0A654FCJ0, Q0WW92
      Conserved Domains (1) summary
      PTZ00037
      Location:7 → 420
      PTZ00037; DnaJ_C chaperone protein; Provisional

    2. NM_180322.2 → NP_850653.1  DNAJ homologue 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850653.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4J1V2
      Conserved Domains (4) summary
      cd10719
      Location:148 → 214
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:119 → 327
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG2214
      Location:10 → 280
      CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
      pfam00226
      Location:15 → 72
      DnaJ; DnaJ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94AW8.2

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