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    CLT3 CRT (chloroquine-resistance transporter)-like transporter 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831090, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CLT3
    Official Full Name
    CRT (chloroquine-resistance transporter)-like transporter 3
    Primary source
    TAIR:AT5G12170
    Locus tag
    AT5G12170
    See related
    Araport:AT5G12170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CRT (chloroquine-resistance transporter)-like transporter 3
    Summary
    Encodes one of the CRT-Like transporters (CLT1/AT5G19380, CLT2/AT4G24460, CLT3/AT5G12170). Required for glutathione homeostasis and stress responses. Mutants lacking these transporters are heavy metal-sensitive, glutathione(GSH)-deficient, and hypersensitive to Phytophthora infection.
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    Genomic context

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    See CLT3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (3931349..3935142)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene cystatin-1 Neighboring gene Rho GTPase activation protein (RhoGAP) with PH domain-containing protein Neighboring gene calcium-dependent protein kinase 17 Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses. Maughan SC, et al. Proc Natl Acad Sci U S A, 2010 Feb 2. PMID 20080670, Free PMC Article
    2. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001085106.2
    NM_001343229.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to oomycetes IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within glutathione transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CRT (chloroquine-resistance transporter)-like transporter 3
    NP_001078575.1
    • CRT (chloroquine-resistance transporter)-like transporter 3 (CLT3); BEST Arabidopsis thaliana protein match is: CRT (chloroquine-resistance transporter)-like transporter 1 (TAIR:AT5G19380.1); Has 215 Blast hits to 213 proteins in 59 species: Archae - 0; Bacteria - 14; Metazoa - 5; Fungi - 2; Plants - 81; Viruses - 0; Other Eukaryotes - 113 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      3931349..3935142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001085106.2 → NP_001078575.1  CRT (chloroquine-resistance transporter)-like transporter 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078575.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LGC9, Q8RWL5, Q9FMP6, Q9FMP7
      UniProtKB/TrEMBL
      A0A178UGU6, A0A5S9Y3W5
      Conserved Domains (1) summary
      cl23754
      Location:118 → 430
      EamA; EamA-like transporter family

    2. NM_001343229.1 → NP_001331541.1  CRT (chloroquine-resistance transporter)-like transporter 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BE74
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RWL5.1

    Gene LinkOut

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