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    CDPK9 calmodulin-like domain protein kinase 9 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832424, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CDPK9
    Official Full Name
    calmodulin-like domain protein kinase 9
    Primary source
    TAIR:AT5G23580
    Locus tag
    AT5G23580
    See related
    Araport:AT5G23580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA CALMODULIN-LIKE DOMAIN PROTEIN KINASE 9; ATCDPK9; ATCPK12; CALCIUM-DEPENDENT PROTEIN KINASE; CALCIUM-DEPENDENT PROTEIN KINASE 12; calmodulin-like domain protein kinase 9; CPK12
    Summary
    unique family of enzymes containing a single polypeptide chain with a kinase domain at the amino terminus and a putative calcium-binding EF hands structure at the carboxyl terminus; recombinant protein is fully active and induced by Ca2+
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    Genomic context

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    See CDPK9 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (7950202..7952619, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Mov34/MPN/PAD-1 family protein Neighboring gene Got1/Sft2-like vescicle transport protein family Neighboring gene XS domain-containing protein / XS zinc finger domain-containing protein-like protein Neighboring gene Transmembrane CLPTM1 family protein Neighboring gene DNAJ heat shock N-terminal domain-containing protein Neighboring gene RNA 2'-phosphotransferase, Tpt1 / KptA family Neighboring gene DYAD protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis Ca(2+)-Dependent Protein Kinase CPK12 Is Involved in Plant Response to Salt Stress. Zhang H, et al. Int J Mol Sci, 2018 Dec 14. PMID 30558245, Free PMC Article
    2. CPK12: A Ca2+-dependent protein kinase balancer in abscisic acid signaling. Zhao R, et al. Plant Signal Behav, 2011 Nov. PMID 22041934, Free PMC Article
    3. The Arabidopsis Ca(2+) -dependent protein kinase CPK12 negatively regulates abscisic acid signaling in seed germination and post-germination growth. Zhao R, et al. New Phytol, 2011 Oct. PMID 21692804
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that CPK12 mediates salt stress tolerance by regulating ion homeostasis and H2O2 production. Down-regulation of CPK12 results in salt hypersensitivity in seedling growth and accumulation of higher levels of Na+ and H2O2. These findings suggest that CPK12 is required for plant adaptation to salt stress.
      Title: The Arabidopsis Ca(2+)-Dependent Protein Kinase CPK12 Is Involved in Plant Response to Salt Stress.
    2. Both up- and downregulation of CPK12 expression result in ABA hypersensitivity.
      Title: CPK12: A Ca2+-dependent protein kinase balancer in abscisic acid signaling.
    3. The Arabidopsis CPK12 is a negative ABA-signaling regulator in seed germination and post-germination growth.
      Title: The Arabidopsis Ca(2+) -dependent protein kinase CPK12 negatively regulates abscisic acid signaling in seed germination and post-germination growth.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_122264.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin-like domain protein kinase 9
    NP_197748.1
    • calmodulin-like domain protein kinase 9 (CDPK9); FUNCTIONS IN: in 6 functions; INVOLVED IN: protein amino acid phosphorylation; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Serine/threonine-protein kinase domain (InterPro:IPR002290), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992), EF-hand (InterPro:IPR018248), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), EF-HAND 2 (InterPro:IPR018249), Calcium-dependent protein kinase (InterPro:IPR020642), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: calcium-dependent protein kinase 2 (TAIR:AT1G35670.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7950202..7952619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122264.5 → NP_197748.1  calmodulin-like domain protein kinase 9 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197748.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42396
      UniProtKB/TrEMBL
      A0A178U7U9
      Conserved Domains (4) summary
      PTZ00184
      Location:316 → 458
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:400 → 459
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd05117
      Location:21 → 279
      STKc_CAMK; The catalytic domain of CAMK family Serine/Threonine Kinases
      pfam00069
      Location:22 → 280
      Pkinase; Protein kinase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42396.1

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