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    ARF8 auxin response factor 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833672, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARF8
    Official Full Name
    auxin response factor 8
    Primary source
    TAIR:AT5G37020
    Locus tag
    AT5G37020
    See related
    Araport:AT5G37020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATARF8; auxin response factor 8; K15O15.1; K15O15_1
    Summary
    Encodes a member of the auxin response factor family. Mediates auxin response via expression of auxin regulated genes. Acts redundantly with ARF6 to control stamen elongation and flower maturation. Expression of ARF8 is controlled by miR167.
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    Genomic context

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    See ARF8 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Sequence:
    Chromosome: 5; NC_003076.8 (14629453..14634454)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene rho GTPase-activating protein Neighboring gene miscRNA Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The full-length Auxin Response Factor 8 isoform ARF8.1 controls pollen cell wall formation and directly regulates TDF1, AMS and MS188 expression. Ghelli R, et al. Plant J, 2023 Feb. PMID 36597651
    2. Disruption and overexpression of auxin response factor 8 gene of Arabidopsis affect hypocotyl elongation and root growth habit, indicating its possible involvement in auxin homeostasis in light condition. Tian CE, et al. Plant J, 2004 Nov. PMID 15469491
    3. Developmental Defects Mediated by the P1/HC-Pro Potyviral Silencing Suppressor Are Not Due to Misregulation of AUXIN RESPONSE FACTOR 8. Mlotshwa S, et al. Plant Physiol, 2016 Nov. PMID 27688620, Free PMC Article
    4. Misregulation of AUXIN RESPONSE FACTOR 8 underlies the developmental abnormalities caused by three distinct viral silencing suppressors in Arabidopsis. Jay F, et al. PLoS Pathog, 2011 May. PMID 21589905, Free PMC Article
    5. bra-miR167a Targets ARF8 and Negatively Regulates Arabidopsis thaliana Immunity against Plasmodiophora brassicae. Liao R, et al. Int J Mol Sci, 2023 Jul 24. PMID 37511608, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. bra-miR167a Targets ARF8 and Negatively Regulates Arabidopsis thaliana Immunity against Plasmodiophora brassicae.
      Title: bra-miR167a Targets ARF8 and Negatively Regulates Arabidopsis thaliana Immunity against Plasmodiophora brassicae.
    2. The full-length Auxin Response Factor 8 isoform ARF8.1 controls pollen cell wall formation and directly regulates TDF1, AMS and MS188 expression.
      Title: The full-length Auxin Response Factor 8 isoform ARF8.1 controls pollen cell wall formation and directly regulates TDF1, AMS and MS188 expression.
    3. A crosstalk between auxin and brassinosteroid regulates leaf shape by modulating growth anisotropy.
      Title: A crosstalk between auxin and brassinosteroid regulates leaf shape by modulating growth anisotropy.
    4. Photoexcited CRY1 and phyB interact directly with ARF6 and ARF8 to regulate their DNA-binding activity and auxin-induced hypocotyl elongation in Arabidopsis.
      Title: Photoexcited CRY1 and phyB interact directly with ARF6 and ARF8 to regulate their DNA-binding activity and auxin-induced hypocotyl elongation in Arabidopsis.
    5. Ectopic expression of UGT84A2 delayed flowering by indole-3-butyric acid-mediated transcriptional repression of ARF6 and ARF8 genes in Arabidopsis
      Title: Ectopic expression of UGT84A2 delayed flowering by indole-3-butyric acid-mediated transcriptional repression of ARF6 and ARF8 genes in Arabidopsis.
    6. these data argue against the previously reported role of increased ARF8 expression in developmental defects caused by P1/HC-Pro.
      Title: Developmental Defects Mediated by the P1/HC-Pro Potyviral Silencing Suppressor Are Not Due to Misregulation of AUXIN RESPONSE FACTOR 8.
    7. Analyses pinpointed misregulation of ARF8 as a major cause for the developmental aberrations exhibited by VSR transgenic plants, but also for the phenotypes induced during normal viral infection caused by the HcPro-encoding Turnip mosaic virus.
      Title: Misregulation of AUXIN RESPONSE FACTOR 8 underlies the developmental abnormalities caused by three distinct viral silencing suppressors in Arabidopsis.
    8. ARF8 influences cell expansion and proliferation during petal growth.
      Title: AUXIN RESPONSE FACTOR8 regulates Arabidopsis petal growth by interacting with the bHLH transcription factor BIGPETALp.
    9. We concluded that ARF6 and ARF8, in parallel with AS1 and AS2, repress the class 1 KNOX genes in developing floral organs to allow progression of the development of these organs.
      Title: Arabidopsis auxin response factor6 and 8 regulate jasmonic acid biosynthesis and floral organ development via repression of class 1 KNOX genes.
    10. Phenotypic plasticity of adventitious rooting is controlled by complex regulation of AUXIN RESPONSE FACTOR transcripts and microRNA abundance. ARF6 and ARF8, targets of miR167, are positive regulators.
      Title: Phenotypic plasticity of adventitious rooting in Arabidopsis is controlled by complex regulation of AUXIN RESPONSE FACTOR transcripts and microRNA abundance.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001085203.1
    NM_001344162.1
    NM_123060.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_negative_effect fruit development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    auxin response factor 8
    NP_001078672.1
    • auxin response factor 8 (ARF8); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: flower development, response to auxin stimulus, fruit development, regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), Transcriptional factor B3 (InterPro:IPR003340), AUX/IAA protein (InterPro:IPR003311), Auxin response factor (InterPro:IPR010525); BEST Arabidopsis thaliana protein match is: auxin response factor 6 (TAIR:AT1G30330.1); Has 6836 Blast hits to 4235 proteins in 292 species: Archae - 0; Bacteria - 185; Metazoa - 1851; Fungi - 437; Plants - 1949; Viruses - 22; Other Eukaryotes - 2392 (source: NCBI BLink).
    NP_198518.1
    • auxin response factor 8 (ARF8); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: flower development, response to auxin stimulus, fruit development, regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), Transcriptional factor B3 (InterPro:IPR003340), AUX/IAA protein (InterPro:IPR003311), Auxin response factor (InterPro:IPR010525); BEST Arabidopsis thaliana protein match is: auxin response factor 6 (TAIR:AT1G30330.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      14629453..14634454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123060.3 → NP_198518.1  auxin response factor 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198518.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MQI4, Q5IRX7, Q9FGV1, Q9ZTR9
      UniProtKB/TrEMBL
      A0A178UFA9, A0A5S9Y8N3
      Conserved Domains (3) summary
      smart01019
      Location:126 → 225
      B3; B3 DNA binding domain
      pfam02309
      Location:707 → 785
      AUX_IAA; AUX/IAA family
      pfam06507
      Location:258 → 335
      Auxin_resp; Auxin response factor

    2. NM_001344162.1 → NP_001331077.1  auxin response factor 8 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BCS5, A0A5S9Y8N3
      Conserved Domains (3) summary
      smart01019
      Location:31 → 130
      B3; B3 DNA binding domain
      pfam02309
      Location:612 → 690
      AUX_IAA; AUX/IAA family
      pfam06507
      Location:163 → 240
      Auxin_resp; Auxin response factor

    3. NM_001085203.1 → NP_001078672.1  auxin response factor 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078672.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6B9KUT7
      Conserved Domains (3) summary
      pfam02309
      Location:707 → 773
      AUX_IAA; AUX/IAA family
      pfam02362
      Location:126 → 225
      B3; B3 DNA binding domain
      pfam06507
      Location:258 → 335
      Auxin_resp; Auxin response factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FGV1.2

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