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    KCO2 Ca2+ activated outward rectifying K+ channel 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834680, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KCO2
    Official Full Name
    Ca2+ activated outward rectifying K+ channel 2
    Primary source
    TAIR:AT5G46370
    Locus tag
    AT5G46370
    See related
    Araport:AT5G46370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATKCO2; ATTPK2; Ca2+ activated outward rectifying K+ channel 2; CA2+ ACTIVATED OUTWARD RECTIFYING K+ CHANNEL 2; MPL12.17; MPL12_17; TANDEM PORE K+ CHANNEL 2
    Summary
    Encodes AtTPK2 (KCO2), a member of the Arabidopsis thaliana K+ channel family of AtTPK/KCO proteins. AtTPK2 is targeted to the vacuolar membrane. May form homomeric ion channels in vivo.
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    Genomic context

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    See KCO2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (18809496..18811870, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ca2+ activated outward rectifying K+ channel 3 Neighboring gene Serine/Threonine-kinase, putative (DUF1296) Neighboring gene Peptidase S41 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Photosynthesis in Arabidopsis Is Unaffected by the Function of the Vacuolar K(+) Channel TPK3. Höhner R, et al. Plant Physiol, 2019 Jul. PMID 31053658, Free PMC Article
    2. Members of the Arabidopsis AtTPK/KCO family form homomeric vacuolar channels in planta. Voelker C, et al. Plant J, 2006 Oct. PMID 16984403
    3. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ca2+ activated outward rectifying K+ channel 2
    NP_199449.1
    • Ca2+ activated outward rectifying K+ channel 2 (KCO2); FUNCTIONS IN: outward rectifier potassium channel activity, calcium ion binding; INVOLVED IN: potassium ion transport; LOCATED IN: plant-type vacuole membrane; EXPRESSED IN: sperm cell; CONTAINS InterPro DOMAIN/s: Potassium channel, two pore-domain (InterPro:IPR003280), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Ion transport 2 (InterPro:IPR013099); BEST Arabidopsis thaliana protein match is: Ca2+ activated outward rectifying K+ channel 6 (TAIR:AT4G18160.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18809496..18811870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124007.3 → NP_199449.1  Ca2+ activated outward rectifying K+ channel 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199449.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1PDM4, Q9FL25, Q9SCY7
      UniProtKB/TrEMBL
      A0A178UQZ6, A0A5S9YC62, A0A7G2FIL3
      Conserved Domains (1) summary
      pfam07885
      Location:152 → 233
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FL25.1

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