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    HK5 histidine kinase 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830938, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HK5
    Official Full Name
    histidine kinase 5
    Primary source
    TAIR:AT5G10720
    Locus tag
    AT5G10720
    See related
    Araport:AT5G10720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AHK5; CKI2; CYTOKININ INDEPENDENT 2; histidine kinase 5; MAJ23.80; MAJ23_80
    Summary
    member of Histidine Kinase
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    Genomic context

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    See HK5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (3385901..3390686)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene centromere protein O Neighboring gene ncRNA Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene Protein phosphatase 2C family protein Neighboring gene uncharacterized protein Neighboring gene enhanced disease resistance-like protein (DUF1336)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of two-component system elements downstream of AHK5 in the stomatal closure response of Arabidopsis thaliana. Mira-Rodado V, et al. Plant Signal Behav, 2012 Nov. PMID 22951399, Free PMC Article
    2. Modulation of ROS production and hormone levels by AHK5 during abiotic and biotic stress signaling. Pham J, et al. Plant Signal Behav, 2012 Aug. PMID 22827948, Free PMC Article
    3. Arabidopsis histidine kinase 5 regulates salt sensitivity and resistance against bacterial and fungal infection. Pham J, et al. New Phytol, 2012 Apr. PMID 22256998
    4. The histidine kinase AHK5 integrates endogenous and environmental signals in Arabidopsis guard cells. Desikan R, et al. PLoS One, 2008 Jun 18. PMID 18560512, Free PMC Article
    5. AHK5 histidine kinase regulates root elongation through an ETR1-dependent abscisic acid and ethylene signaling pathway in Arabidopsis thaliana. Iwama A, et al. Plant Cell Physiol, 2007 Feb. PMID 17202180

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data suggest the presence of a complex TCS signaling network comprising of at least AHK5, several AHPs and response regulators, which modulate stomatal closure in response to HO and ethylene.
      Title: Identification of two-component system elements downstream of AHK5 in the stomatal closure response of Arabidopsis thaliana.
    2. The first crystal structure of a plant histidine kinase receiver domain(RD), AHK5(RD), in complex with one of its cognate phosphotransfer proteins, AHP1.
      Title: Structure-function analysis of Arabidopsis thaliana histidine kinase AHK5 bound to its cognate phosphotransfer protein AHP1.
    3. A model which proposes a role for reactive oxygen species (ROS) and hormones in integrating abiotic and biotic stress responses via AHK5, is proposed.
      Title: Modulation of ROS production and hormone levels by AHK5 during abiotic and biotic stress signaling.
    4. This is the first report of a role for AHK5 in the regulation of survival following challenge by a hemi-biotrophic bacterium and a necrotrophic fungus, as well as in the growth response to salt stress.
      Title: Arabidopsis histidine kinase 5 regulates salt sensitivity and resistance against bacterial and fungal infection.
    5. findings identify an integral signalling function for AHK5 that acts to integrate multiple signals via H(2)O(2) homeostasis and is independent of ABA signalling in guard cells
      Title: The histidine kinase AHK5 integrates endogenous and environmental signals in Arabidopsis guard cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121110.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphorelay sensor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein histidine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein histidine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to molecule of bacterial origin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to nitric oxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinin-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ethylene-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histidine kinase 5
    NP_196633.2
    • histidine kinase 5 (HK5); FUNCTIONS IN: protein histidine kinase activity; INVOLVED IN: cytokinin mediated signaling pathway; LOCATED IN: vacuole; EXPRESSED IN: male gametophyte, root; CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, homodimeric (InterPro:IPR009082), CheY-like (InterPro:IPR011006), Signal transduction histidine kinase, core (InterPro:IPR005467), Signal transduction response regulator, receiver domain (InterPro:IPR001789), Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain (InterPro:IPR003661), ATPase-like, ATP-binding domain (InterPro:IPR003594), Signal transduction histidine kinase-related protein, C-terminal (InterPro:IPR004358); BEST Arabidopsis thaliana protein match is: calmodulin-binding protein-related (TAIR:AT5G10680.1); Has 142896 Blast hits to 126384 proteins in 3154 species: Archae - 1152; Bacteria - 126386; Metazoa - 257; Fungi - 2334; Plants - 2049; Viruses - 33; Other Eukaryotes - 10685 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      3385901..3390686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121110.2 → NP_196633.2  histidine kinase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196633.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3S4A7, Q9FT60
      UniProtKB/TrEMBL
      A0A178ULC2, A0A5S9Y3R1, A0A654G0J4
      Conserved Domains (1) summary
      PRK11107
      Location:371 → 922
      PRK11107; hybrid sensory histidine kinase BarA; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3S4A7.1

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