Atp5po ATP synthase peripheral stalk subunit OSCP [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp5poprovided by MGI
Official Full Name: ATP synthase peripheral stalk subunit OSCPprovided by MGI
Primary source: MGI:MGI:106341
See related: Ensembl:ENSMUSG00000022956 AllianceGenome:MGI:106341
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ATPO; OSCP; Atp5o; D12Wsu28e
Summary: Predicted to enable estradiol binding activity. Predicted to contribute to ATP hydrolysis activity and proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 7. Orthologous to human ATP5PO (ATP synthase peripheral stalk subunit OSCP). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 233.2), placenta adult (RPKM 134.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C4; 16 53.26 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (91722111..91728518, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (91925223..91931630, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Modulation of OSCP mitigates mitochondrial and synaptic deficits in a mouse model of Alzheimer's pathology.
Title: Modulation of OSCP mitigates mitochondrial and synaptic deficits in a mouse model of Alzheimer's pathology.
Estrogen receptor beta modulates mitochondrial permeability transition by regulating CypD interaction with OSCP.
Title: Estrogen receptor beta modulates permeability transition in brain mitochondria.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125676 (e-PCR)
- UniSTS:141863

RH136609 (e-PCR)
- UniSTS:210589

Atp5o (e-PCR), detects polymorphism
- UniSTS:259040

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables estradiol binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATP synthase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proton motive force-driven mitochondrial ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton motive force-driven mitochondrial ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven mitochondrial ATP synthesis	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of proton-transporting ATP synthase complex	ISO Inferred from Sequence Orthology more info
part_of proton-transporting ATP synthase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of proton-transporting ATP synthase complex, coupling factor F(o)	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP synthase subunit O, mitochondrial

Names: ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit; DNA segment, Chr 12, Wayne State University 28, expressed; oligomycin sensitivity conferral protein

NP_613063.1

EC 7.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.